SPG3A (ATL1) (NM_181598) Human Untagged Clone

CAT#: SC317947

ATL1 (untagged)-Human atlastin GTPase 1 (ATL1), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ATL1
• Synonyms: AD-FSP; atlastin1; FSP1; GBP3; HSN1D; SPG3; SPG3A
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_181598, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGCCAAGAACCGCAGGGACAGAAACAGTTGGGGTGGATTTTCGGAAAAGACATATGAATGGAGCTCAG
  AAGAGGAGGAGCCAGTGAAAAAGGCAGGACCAGTCCAAGTCCTCATTGTCAAAGATGACCATTCCTTTGA
  GTTAGATGAAACTGCATTAAATCGGATCCTTCTCTCGGAGGCTGTCAGAGACAAGGAGGTTGTTGCTGTA
  TCTGTTGCTGGAGCATTTAGAAAAGGAAAATCATTCCTGATGGACTTCATGTTGAGATACATGTACAACC
  AGGAATCAGTTGATTGGGTTGGAGACTACAATGAACCATTGACTGGTTTTTCATGGAGAGGTGGATCTGA
  GCGAGAGACCACAGGAATTCAGATATGGAGTGAAATCTTCCTTATCAATAAACCTGATGGTAAAAAGGTT
  GCAGTGTTATTGATGGATACTCAGGGAACCTTTGATAGTCAGTCAACTTTGAGAGATTCAGCCACAGTAT
  TTGCCCTTAGCACAATGATCAGCTCAATACAGGTATATAACTTATCCCAAAATGTCCAGGAGGATGATCT
  TCAGCACCTCCAGCTTTTCACTGAGTATGGCAGACTGGCAATGGAGGAAACATTCCTGAAGCCATTTCAG
  AGTCTGATATTTCTTGTTCGAGACTGGAGTTTCCCATACGAATTTTCATATGGAGCCGATGGTGGTGCCA
  AATTCTTGGAAAAACGCCTCAAGGTCTCAGGGAACCAGCATGAAGAACTACAGAACGTCAGAAAACACAT
  CCATTCCTGTTTCACCAACATTTCCTGTTTTCTGCTACCTCATCCTGGCTTAAAAGTAGCTACCAATCCA
  AACTTTGATGGAAAATTGAAAGAAATAGATGATGAATTCATCAAAAACTTGAAAATACTGATTCCTTGGC
  TACTTAGTCCCGAGAGCCTAGATATTAAAGAGATCAATGGGAATAAAATCACCTGCCGGGGTCTGGTGGA
  GTACTTCAAGGCTTATATAAAGATCTATCAAGGTGAAGAATTACCACATCCCAAATCCATGTTACAGGCC
  ACAGCAGAAGCTAACAATTTAGCAGCCGTGGCAACTGCCAAGGACACATACAACAAAAAAATGGAAGAGA
  TTTGTGGTGGTGACAAACCATTTCTGGCCCCAAATGACTTGCAGACCAAACACCTGCAACTTAAGGAAGA
  ATCTGTGAAGCTATTCCGAGGGGTGAAGAAGATGGGTGGGGAAGAATTTAGCCGGCGTTACCTGCAGCAG
  TTGGAGAGTGAAATAGATGAACTTTACATCCAATATATCAAGCACAATGATAGCAAAAATATCTTCCATG
  CAGCTCGTACCCCAGCCACACTGTTTGTAGTCATCTTTATCACATATGTGATTGCTGGTGTGACTGGATT
  CATTGGTTTGGACATCATAGCTAGCCTATGCAATATGATAATGGGACTGACCCTTATCACCCTGTGCACT
  TGGGCATATATCCGGTACTCTGGAGAATACCGAGAGCTGGGAGCTGTAATAGACCAGGTGGCTGCAGCTC
  TGTGGGACCAGGCTTTGTACAAGCTTTACAGTGCAGCAGCAACCCACAGACATCTGTATCATCAAGCTTT
  CCCTACACCAAAGTCGGAATCTACTGAACAATCAGAAAAGAAAAAAATGTAA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_181598
• ORF Size: 1662 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_181598.3, NP_853629.2
• RefSeq Size: 2637
• RefSeq ORF: 1662
• Locus ID: 51062
• Protein Families: Druggable Genome, Transmembrane
• Gene Summary: The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode isoform b.