PRDM9 (NM_020227) Human Untagged Clone

CAT#: SC318366

PRDM9 (untagged)-Human PR domain containing 9 (PRDM9)


  "NM_020227" in other vectors (2)

Reconstitution Protocol

USD 1,810.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol PRDM9
Synonyms KMT8B; MEISETZ; MSBP3; PFM6; ZNF899
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF sequence for NM_020227 edited
ATGAGCCCTGAAAAGTCCCAAGAGGAGAGCCCAGAAGAAGACACAGAGAGAACAGAGCGG
AAGCCCATGGTCAAAGATGCCTTCAAAGACATTTCCATATACTTCACCAAGGAAGAATGG
GCAGAGATGGGAGACTGGGAGAAAACTCGCTATAGGAATGTGAAAAGGAACTATAATGCA
CTGATTACTATAGGTCTCAGAGCCACTCGACCAGCTTTCATGTGTCACCGAAGGCAGGCC
ATCAAACTCCAGGTGGATGACACAGAAGATTCTGATGAAGAATGGACCCCTAGGCAGCAA
GTCAAACCTCCTTGGATGGCCTTAAGAGTGGAACAGCGTAAACACCAGAAGGGAATGCCC
AAGGCGTCATTCAGTAATGAATCTAGTTTGAAAGAATTGTCAAGAACAGCAAATTTACTG
AATGCAAGTGGCTCAGAGCAGGCTCAGAAACCAGTGTCCCCTTCTGGAGAAGCAAGTACC
TCTGGACAGCACTCAAGACTAAAACTGGAACTCAGGAAGAAGGAGACTGAAAGAAAGATG
TATAGCCTGCGAGAAAGAAAGGGTCATGCATACAAAGAGGTCAGCGAGCCGCAGGATGAT
GATTACCTCTATTGTGAGATGTGTCAGAACTTCTTCATTGACAGCTGTGCTGCCCATGGG
CCCCCTACATTTGTAAAGGACAGTGCAGTGGACAAGGGGCACCCCAACCGTTCAGCCCTC
AGTCTGCCCCCAGGGCTGAGAATTGGGCCATCAGGCATCCCTCAGGCTGGGCTTGGAGTA
TGGAATGAGGCATCTGATCTGCCGCTGGGTCTGCACTTTGGCCCTTATGAGGGCCGAATT
ACAGAAGACGAAGAGGCAGCCAACAATGGATACTCCTGGCTGATCACCAAGGGGAGAAAC
TGCTATGAGTATGTGGATGGAAAAGATAAATCCTGGGCCAACTGGATGAGGTATGTGAAC
TGTGCCCGGGATGATGAAGAGCAGAACCTGGTGGCCTTCCAGTACCACAGGCAGATCTTC
TATAGAACCTGCCGAGTCATTAGGCCAGGCTGTGAACTGCTGGTCTGGTATGGGGATGAA
TACGGCCAGGAACTGGGCATCAAGTGGGGCAGCAAGTGGAAGAAAGAGCTCATGGCAGGG
AGAGAACCAAAGCCAGAGATCCATCCATGTCCCTCATGCTGTCTGGCCTTTTCAAGTCAG
AAATTTCTCAGTCAACATGTAGAACGCAATCACTCCTCTCAGAACTTCCCAGGACCATCT
GCAAGAAAACTCCTCCAACCAGAGAATCCCTGCCCAGGGGATCAGAATCAGGAGCAGCAA
TATCCAGATCCACACAGCCGTAATGACAAAACCAAAGGTCAAGAGATCAAAGAAAGGTCC
AAACTCTTGAATAAAAGGACATGGCAGAGGGAGATTTCAAGGGCCTTTTCTAGCCCACCC
AAAGGACAAATGGGGAGCTGTAGAGTGGGAAAAAGAATAATGGAAGAAGAGTCCAGAACA
GGCCAGAAAGTGAATCCAGGGAACACAGGCAAATTATTTGTGGGGGTAGGAATCTCAAGA
ATTGCAAAAGTCAAGTATGGAGAGTGTGGACAAGGTTTCAGTGTTAAATCAGATGTTATT
ACACACCAAAGGACACATACAGGGGAGAAGCTCTACGTCTGCAGGGAGTGTGGGCGGGGC
TTTAGCTGGAAGTCACACCTCCTCATTCACCAGAGGATACACACAGGGGAGAAGCCCTAT
GTCTGCAGGGAGTGTGGGCGGGGCTTTAGCTGGCAGTCAGTCCTCCTCACTCACCAGAGG
ACACACACAGGGGAGAAGCCCTATGTCTGCAGGGAGTGTGGGCGGGGCTTTAGCCGGCAG
TCAGTCCTCCTCACTCACCAGAGGAGACACACAGGGGAGAAGCCCTATGTCTGCAGGGAG
TGTGGGCGGGGCTTTAGCCGGCAGTCAGTCCTCCTCACTCACCAGAGGAGACACACAGGG
GAGAAGCCCTATGTCTGCAGGGAGTGTGGGCGGGGCTTTAGCTGGCAGTCAGTCCTCCTC
ACTCACCAGAGGACACACACAGGGGAGAAGCCCTATGTCTGCAGGGAGTGTGGGCGGGGC
TTTAGCTGGCAGTCAGTCCTCCTCACTCACCAGAGGACACACACAGGGGAGAAGCCCTAT
GTCTGCAGGGAGTGTGGGCGGGGCTTTAGCAATAAGTCACACCTCCTCAGACACCAGAGG
ACACACACAGGGGAGAAGCCCTATGTCTGCAGGGAGTGTGGGCGGGGCTTTCGCGATAAG
TCACACCTCCTCAGACACCAGAGGACACACACAGGGGAGAAGCCCTATGTCTGCAGGGAG
TGTGGGCGGGGCTTTAGAGATAAGTCAAACCTCCTCAGTCACCAGAGGACACACACAGGG
GAGAAGCCCTATGTCTGCAGGGAGTGTGGGCGGGGCTTTAGCAATAAGTCACACCTCCTC
AGACACCAGAGGACACACACAGGGGAGAAGCCCTATGTCTGCAGGGAGTGTGGGCGGGGC
TTTCGCAATAAGTCACACCTCCTCAGACACCAGAGGACACACACAGGGGAGAAGCCCTAC
GTCTGCAGGGAGTGTGGGCGGGGCTTTAGCGATAGGTCAAGCCTCTGCTATCACCAGAGG
ACACACACAGGGGAGAAGCCCTACGTCTGCAGGGAGGATGAGTAA
Restriction Sites Please inquire     
ACCN NM_020227
ORF Size 2685 bp
Insert Size 3000
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
Reference Data
RefSeq NM_020227.2, NP_064612.2
RefSeq Size 3691
RefSeq ORF 2685
Locus ID 56979
Gene Summary The protein encoded by this gene is a zinc finger protein with histone methyltransferase activity that catalyzes histone H3 lysine 4 trimethylation (H3K4me3) during meiotic prophase. This protein contains multiple domains, including a Kruppel-associated box (KRAB) domain, an SSX repression domain (SSXRD), a PRD1-BF1 and RIZ homologous region, a subclass of SET (PR/SET) domain, and a tandem array of C2H2 zinc fingers. The zinc finger array recognizes a short sequence motif, leading to local H3K4me3, and meiotic recombination hotspot activity. The observed allelic variation alters the DNA-binding sequence specificity of the protein, resulting in distinct meiotic recombination hotspots amongst individuals and populations. Multiple alternate alleles of this gene have been described. [provided by RefSeq, Jul 2015]
Transcript Variant: This variant (PRDM9 B allele, PMID:20044539) matches the reference genome sequence and encodes isoform PRDM9 B.

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