CNKSR2 (NM_014927) Human Untagged Clone

CAT#: SC318455

CNKSR2 (untagged)-Human connector enhancer of kinase suppressor of Ras 2 (CNKSR2), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CNKSR2
• Synonyms: CNK2; KSR2; MAGUIN; MRXSHG
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_014927, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGCTCTGATAATGGAACCGGTGAGCAAATGGTCTCCGAGTCAAGTAGTGGACTGGATGAAAGGTCTTG
  ATGACTGTTTGCAGCAGTATATTAAGAACTTTGAGAGGGAGAAGATCAGTGGGGACCAGCTGCTGCGCAT
  TACACATCAGGAGCTAGAAGATCTGGGGGTCAGCCGCATTGGCCATCAGGAACTGATCTTGGAAGCAGTT
  GACCTTCTGTGTGCATTGAATTATGGCTTGGAAACAGAAAATCTAAAAACCCTTTCTCACAAGTTGAATG
  CATCTGCCAAAAATCTGCAGAATTTTATAACAGGAAGGAGAAGGAGTGGCCATTATGATGGGAGGACCAG
  CCGAAAATTGCCAAACGACTTTCTGACCTCAGTTGTGGATCTGATTGGAGCAGCCAAGAGTCTGCTTGCC
  TGGTTGGACAGGTCACCATTTGCTGCTGTGACAGACTATTCAGTTACAAGAAATAATGTCATACAACTCT
  GCCTGGAGTTAACAACAATTGTGCAACAGGATTGTACTGTATATGAAACAGAGAATAAAATTCTTCACGT
  GTGTAAAACTCTTTCTGGAGTCTGTGACCACATCATATCCCTGTCGTCAGATCCTCTGGTTTCACAGTCT
  GCTCACCTGGAAGTGATTCAACTGGCAAACATTAAACCAAGCGAAGGGCTGGGTATGTATATTAAATCTA
  CATATGATGGCCTCCATGTAATTACTGGAACCACAGAAAATTCACCTGCAGATCGGTGCAAGAAAATCCA
  TGCTGGCGATGAAGTGATTCAAGTTAATCATCAGACTGTGGTGGGGTGGCAGTTGAAAAATTTGGTGAAT
  GCACTACGAGAGGACCCGAGTGGTGTTATCTTAACTTTGAAAAAGCGACCTCAGAGCATGCTTACCTCAG
  CACCAGCTTTACTGAAAAATATGAGATGGAAGCCCCTTGCTCTGCAGCCTCTTATACCTAGAAGTCCCAC
  AAGCAGCGTTGCCACGCCTTCCAGCACCATCAGTACACCCACCAAAAGAGACAGTTCTGCCCTCCAGGAT
  CTCTACATTCCCCCTCCTCCTGCAGAACCATATATTCCCAGGGATGAAAAAGGAAACCTTCCTTGTGAAG
  ACCTCAGAGGACATATGGTGGGCAAGCCAGTGCATAAGGGATCTGAATCACCAAATTCATTTCTGGATCA
  GGAATATCGAAAGAGATTTAATATTGTCGAAGAAGATACTGTCTTATATTGCTATGAATATGAAAAAGGA
  AGATCAAGTAGTCAAGGAAGACGAGAAAGCACCCCAACTTATGGCAAGCTACGACCTATATCTATGCCAG
  TGGAATATAATTGGGTGGGGGACTATGAAGATCCAAATAAGATGAAGAGAGATAGTAGAAGAGAAAACTC
  TCTACTTCGGTATATGAGCAATGAAAAGATTGCTCAAGAAGAATACATGTTTCAGAGAAACAGCAAAAAG
  GACACAGGGAAGAAGTCAAAAAAGAAGGGTGATAAGAGTAATAGCCCAACTCACTATTCATTGCTACCTA
  GTTTACAAATGGATGCACTGAGACAAGACATCATGGGCACTCCTGTGCCAGAGACCACACTATACCATAC
  ATTTCAGCAGTCCTCACTGCAGCACAAATCAAAGAAGAAAAACAAAGGTCCTATAGCAGGCAAGAGCAAA
  AGACGAATTTCTTGCAAAGATCTTGGCCGTGGTGACTGTGAGGGCTGGCTTTGGAAAAAGAAAGATGCGA
  AGAGTTACTTTTCACAGAAATGGAAAAAATATTGGTTTGTCCTAAAGGATGCATCCCTTTATTGGTATAT
  TAATGAGGAGGATGAAAAAGCAGAAGGATTCATTAGCCTGCCTGAATTTAAAATTGATAGAGCCAGTGAA
  TGCCGCAAAAAATATGCATTCAAAGCCTGTCATCCTAAAATCAAAAGCTTTTATTTTGCTGCTGAACATC
  TTGATGATATGAACAGGTGGCTTAACAGAATTAATATGCTGACTGCAGGATATGCAGAAAGAGAGAGGAT
  TAAGCAGGAACAAGATTACTGGAGTGAGAGTGACAAGGAAGAAGCAGATACTCCATCAACACCAAAACAA
  GATAGCCCTCCACCCCCATATGATACATACCCACGACCTCCCTCGATGAGTTGCGCCAGTCCTTATGTGG
  AAGCAAAACATAGCCGACTTTCCTCCACGGAGACTTCTCAGTCTCAGTCTTCTCATGAGGAGTTTCGCCA
  GGAAGTAACTGGGAGCAGTGCAGTGTCTCCCATTCGCAAGACAGCCAGTCAGCGCCGCTCCTGGCAGGAT
  TTAATTGAGACGCCACTGACAAGTTCAGGCTTACACTATCTTCAGACTCTGCCCCTGGAGGATTCTGTCT
  TCTCTGACTCCGCGGCCATCTCCCCAGAGCACAGGCGGCAGTCTACCCTGCCAACTCAGAAATGCCACCT
  GCAGGATCACTATGGGCCATACCCCTTAGCTGAGAGTGAGAGGATGCAAGTGCTAAATGGAAATGGGGGC
  AAGCCTCGAAGTTTTACTCTGCCTCGAGATAGCGGGTTCAACCATTGCTGTCTGAATGCTCCAGTTAGTG
  CCTGTGACCCACAGGATGACGTGCAACCCCCAGAGGTGGAGGAAGAGGAGGAGGAGGAGGAGGAGGAAGG
  GGAGGCAGCAGGGGAAAACATAGGAGAAAAAAGTGAAAGCAGAGAAGAAAAGTTAGGAGACTCATTGCAA
  GATTTATACAGGGCACTGGAGCAGGCCAGTCTGTCACCACTAGGAGAACATCGTATTTCAACCAAGATGG
  AATACAAGCTATCATTTATAAAAAGATGTAATGATCCTGTAATGAATGAAAAACTACACCGGCTGAGAAT
  TCTCAAAAGCACTTTAAAGGCCAGAGAAGGGGAAGTAGCCATTATCGATAAAGTCCTAGACAATCCAGAC
  TTGACATCTAAAGAATTCCAACAATGGAAGCAGATGTACCTCGACCTTTTCTTGGATATCTGTCAAAATA
  CCACCTCAAATGACCCACTGAGTATTTCTTCTGAAGTAGATGTAATCACTTCCTCTCTAGCACACACTCA
  TTCATACATTGAAACGCATGTCTAA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_014927
• ORF Size: 3105 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_014927.3, NP_055742.2
• RefSeq Size: 5769
• RefSeq ORF: 3105
• Locus ID: 22866
• Domains: PDZ, SAM, PH
• Gene Summary: This gene encodes a multidomain protein that functions as a scaffold protein to mediate the mitogen-activated protein kinase pathways downstream from Ras. This gene product is induced by vitamin D and inhibits apoptosis in certain cancer cells. It may also play a role in ternary complex assembly of synaptic proteins at the postsynaptic membrane and coupling of signal transduction to membrane/cytoskeletal remodeling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
  Transcript Variant: This variant (1, also known as CNK2A and MAGUIN-1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.