CHMP2A (NM_014453) Human Untagged Clone

CAT#: SC319048

CHMP2A (untagged)-Human chromatin modifying protein 2A (CHMP2A), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CHMP2A
• Synonyms: BC-2; BC2; CHMP2; VPS2; VPS2A
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_014453.2 CTGGACCGTGGATCCCGGGCGGGCGTGCGGGCGGCAGCGTACGAGGCCTTCTACTCGCCC
  GGGTGTCCGGTGCCTCGCTTCTCCCTGGGACCCTGTCGTCAACATCGAGGCCTGCCAGTG
  AGCTTCTACCATCATGGACCTATTGTTCGGGCGCCGGAAGACGCCAGAGGAGCTACTGCG
  GCAGAACCAGAGGGCCCTGAACCGTGCCATGCGGGAGCTGGACCGCGAGCGACAGAAACT
  AGAGACCCAGGAGAAGAAAATCATTGCAGACATTAAGAAGATGGCCAAGCAAGGCCAGAT
  GGATGCTGTTCGCATCATGGCAAAAGACTTGGTGCGCACCCGGCGCTATGTGCGCAAGTT
  TGTATTGATGCGGGCCAACATCCAGGCTGTGTCCCTCAAGATCCAGACACTCAAGTCCAA
  CAACTCGATGGCACAAGCCATGAAGGGTGTCACCAAGGCCATGGGCACCATGAACAGACA
  GCTGAAGTTGCCCCAGATCCAGAAGATCATGATGGAGTTTGAGCGGCAGGCAGAGATCAT
  GGATATGAAGGAGGAGATGATGAATGATGCCATTGATGATGCCATGGGTGATGAGGAAGA
  TGAAGAGGAGAGTGATGCTGTGGTGTCCCAGGTTCTGGATGAGCTGGGACTTAGCCTAAC
  AGATGAGCTGTCGAACCTCCCCTCAACTGGGGGCTCGCTTAGTGTGGCTGCTGGTGGGAA
  AAAAGCAGAGGCCGCAGCCTCAGCCCTAGCTGATGCTGATGCAGACCTGGAGGAACGGCT
  TAAGAACCTGCGGAGGGACTGAGTGCCCCTGCCACTCCGAGATAACCAGTGGATGCCCAG
  GATCTTTTACCACAACCCCTCTGTAATAAAAGAGATTTGACACTAAAAAAAAAAAAAAAA
  AAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_014453.2 unedited
  GGTACCTTTGTATACGACTCCTATAGGGCGGCCGGGTAATTCGGCACGAGGCTGGACCGT
  GGATCCCGGGCGGGCGTGCGGGCGGCAGCGTACGAGGCCTTCTACTCGCCCGGGTGTCCG
  GTGCCTCGCTTCTCCCTGGGACCCTGTCGTCAACATCGAGGCCTGCCAGTGAGCTTCTAC
  CATCATGGACCTATTGTTCGGGCGCCGGAAGACGCCAGAGGAGCTACTGCGGCAGAACCA
  GAGGGCCCTGAACCGTGCCATGCGGGAGCTGGACCGCGAGCGACAGAAACTAGAGACCCA
  GGAGAAGAAAATCATTGCAGACATTAAGAAGATGGCCAAGCAAGGCCAGATGGATGCTGT
  TCGCATCATGGCAAAAGACTTGGTGCGCACCCGGCGCTATGTGCGCAAGTTTGTATTGAT
  GCGGGCCAACATCCAGGCTGTGTCCCTCAAGATCCAGACACTCAAGTCCAACAACTCGAT
  GGCACAAGCCATGAAGGGTGTCACCAAGGCCATGGGCACCATGAACAGACAGCTGAAGTT
  GCCCCAGATCCAGAAGATCATGATGGAGTTTGAGCGGCAGGCAGAGATCATGGATATGAA
  GGAGGAGATGATGAATGATGCCATTGATGATGCCATGGGTGATGAGGAAGATGAAGAGGA
  GAGTGATGCTGTGGTGTCCCAGGTTCTGGATGAGCTGGGACTTAGCCTAACAGATGAGCT
  GTCGAACCTCCCCTCAACTGGGGGCTCGCTTAGTGTGGCTGCTGGTGGGAAAAAAGCAGA
  GGCCGCAGCCTCAGCCCTAGCTGATGCTGATGCAGACCTGAGACGGCTTAGGACCTGGCG
  GAGGACTGATTGCCCTGCCACCTCGAGAATACAGTGATGCCCAGGATTCTTTAACACAAG
  CCCTCTGTATAAAGAGATTGACCCTTCCAAAACAAAAACAGGA
• Restriction Sites: Please inquire
• ACCN: NM_014453
• ORF Size: 669 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_014453.2, NP_055268.1
• RefSeq Size: 926
• RefSeq ORF: 669
• Locus ID: 27243
• Domains: DUF279
• Protein Pathways: Endocytosis
• Gene Summary: CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]). [supplied by OMIM, Mar 2008]
  Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.