Apc5 (ANAPC5) (NM_016237) Human Untagged Clone

CAT#: SC319159

ANAPC5 (untagged)-Human anaphase promoting complex subunit 5 (ANAPC5), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ANAPC5
• Synonyms: APC5
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_016237.3 CCTTGTGGTGACAACTGGCGGCAGCGCGCCGCGGGCCCGAGACTTAGTCTCGGGCCGCCA
  TGGCCAGCGTCCACGAGAGCCTCTACTTCAATCCCATGATGACCAATGGGGTTGTGCACG
  CCAATGTGTTCGGCATCAAGGACTGGGTGACGCCGTACAAGATCGCGGTGCTGGTGCTGC
  TGAACGAGATGAGCCGCACAGGCGAGGGCGCCGTCAGCCTCATGGAGCGGCGGAGGCTCA
  ACCAGCTGCTCCTGCCCCTGCTGCAGGGCCCAGATATTACACTGTCAAAACTTTACAAGT
  TAATTGAAGAGTCTTGTCCACAGCTGGCAAATTCAGTGCAGATCAGAATCAAACTGATGG
  CTGAAGGCGAGTTGAAGGATATGGAACAGTTTTTTGATGACCTTTCAGATTCTTTCTCTG
  GAACTGAACCAGAGGTTCACAAAACAAGTGTAGTAGGTTTGTTTCTGCGTCACATGATCT
  TGGCCTACAGTAAGCTTTCTTTCAGCCAAGTGTTTAAACTGTACACTGCCCTTCAGCAGT
  ACTTCCAGAATGGTGAGAAAAAGACAGTGGAGGATGCTGATATGGAACTGACCAGTAGAG
  ATGAGGGTGAAAGAAAAATGGAAAAAGAAGAACTTGATGTATCTGTAAGAGAAGAGGAGG
  TATCTTGCAGTGGGCCTCTGTCCCAAAAACAAGCAGAATTTTTTCTTTCTCAACAGGCTT
  CTTTGCTAAAGAATGATGAGACTAAGGCCCTCACTCCAGCTTCCTTGCAGAAGGAATTAA
  ACAATTTGTTGAAATTTAATCCTGATTTTGCTGAAGCGCATTATCTCAGCTACTTAAACA
  ACCTCCGTGTCCAAGATGTTTTCAGTTCAACACACAGTCTCCTCCATTATTTTGATCGTC
  TGATTCTTACCGGAGCCGAAAGCAAAAGTAATGGGGAAGAGGGCTATGGCCGGAGCTTGA
  GATACGCCGCTCTGAATCTTGCCGCCCTGCACTGCCGCTTCGGTCACTATCAACAGGCAG
  AGCTCGCCCTGCAGGAGGCAATTAGGATTGCCCAGGAGTCCAACGATCACGTGTGTCTCC
  AGCACTGTTTGAGCTGGCTTTATGTGCTGGGGCAGAAGAGATCCGATAGCTATGTTCTGC
  TGGAGCATTCTGTGAAGAAGGCAGTACATTTTGGGTTACCGTACCTCGCCTCCCTGGGAA
  TACAGTCCCTTGTTCAACAGAGAGCTTTTGCTGGGAAGACGGCAAACAAGCTGATGGATG
  CCCTAAAGGACTCCGACCTCCTGCACTGGAAACACAGCCTGTCAGAGCTCATCGATATCA
  GCATCGCACAGAAAACGGCCATCTGGAGGCTGTATGGCCGCAGCACCATGGCACTGCAAC
  AGGCCCAGATGTTGCTGAGCATGAACAGCCTGGAGGCGGTGAATGCGGGCGTGCAGCAGA
  ACAACACAGAGTCCTTTGCTGTCGCACTCTGCCACCTCGCAGAGCTACACGCGGAGCAGG
  GCTGTTTTGCTGCAGCTTCTGAAGTGTTAAAGCACTTGAAGGAACGATTTCCGCCTAATA
  GTCAGCACGCCCAGTTATGGATGTTATGTGATCAAAAAATACAGTTTGACAGAGCAATGA
  ATGATGGCAAATATCATTTGGCTGATTCACTTGTTACAGGAATCACAGCTCTCAATAGCA
  TAGAGGGTGTTTATAGGAAAGCGGTTGTATTACAAGCTCAGAACCAAATGTCAGAGGCAC
  ATAAGCTTTTACAAAAATTGTTGGTTCATTGTCAGAAACTGAAGAACACAGAAATGGTGA
  TCAGTGTCCTACTGTCCGTGGCAGAGCTGTACTGGCGATCTTCCTCCCCTACCATCGCGC
  TGCCCATGCTCCTGCAGGCTCTGGCCCTCTCCAAGGAGTACCGGTTACAGTACTTGGCCT
  CTGAAACAGTGCTGAACTTGGCTTTTGCGCAGCTCATTCTTGGAATCCCAGAACAGGCCT
  TAAGTCTTCTCCACATGGCCATCGAGCCCATCTTGGCTGACGGGGCTATCCTGGACAAAG
  GTCGTGCCATGTTCTTAGTGGCCAAGTGCCAGGTGGCTTCAGCAGCTTCCTACGATCAGC
  CGAAGAAAGCAGAAGCTCTGGAGGCTGCCATCGAGAACCTCAATGAAGCCAAGAACTATT
  TTGCAAAGGTTGACTGCAAAGAGCGCATCAGGGACGTCGTTTACTTCCAGGCCAGACTCT
  ACCATACCCTGGGGAAGACCCAGGAGAGGAACCGGTGTGCGATGCTCTTCCGGCAGCTGC
  ATCAGGAGCTGCCCTCTCATGGGGTACCCTTGATAAACCATCTCTAGAGAGGACATCCCT
  GCTGGGCTGCTGTGCAGAGTATAAGATTTTGGACTTGTTCATGTCCCCTCTCTCCCTATA
  AATGATGTATTTGTGACACCCTATCTTGTCAATAAACAGCATTCTGATTAAAAAAAAAAA
  AAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_016237.3 unedited
  GACCTTATGTATACGACTCCTATAGGGCGGCCGGGTAATTTTTTCTTTCTCAACAGGCTT
  CTTTGCTAAAGAATGATGAGACTAAGGCCCTCACTCCAGCTTCCTTGCAGAAGGAATTAA
  ACAATTTGTTGAAATTTAATCCTGATTTTGCTGAAGCGCATTATCTCAGCTACTTAAACA
  ACCTCCGTGTCCAAGATGTTTTCAGTTCAACACACAGTCTCCTCCATTATTTTGATCGTC
  TGATTCTTACCGGAGCCGAAAGCAAAAGTAATGGGGAAGAGGGCTATGGCCGGAGCTTGA
  GATACGCCGCTCTGAATCTTGCCGCCCTGCACTGCCGCTTCGGTCACTATCAACAGGCAG
  AGCTCGCCCTGCAGGAGGCAATTAGGATTGCCCAGGAGTCCAACGATCACGTGTGTCTCC
  AGCACTGTTTGAGCTGGCTTTATGTGCTGGGGCAGAAGAGATCCGATAGCTATGTTCTGC
  TGGAGCATTCTGTGAAGAAGGCAGTACATTTTGGGTTACCGTACCTCGCCTCCCTGGGAA
  TACAGTCCCTTGTTCAACAGAGAGCTTTTGCTGGGAAGACGGCAAACAAGCTGATGGATG
  CCCTAAAGGACTCCGACCTCCTGCACTGGAAACACAGCCTGTCAGAGCTCATCGATATCA
  GCATCGCACAGAAAACGGCCATCTGGAGGCTGTATGGCCGCAGCACCATGGCACTGCAAC
  AGGCCCAGATGTTGCTGAGCATGAACAGCCTGGAGCGGTGAATGCGGGCGTGCAGCAGAC
  AACACAGAGTCCTTTGCTGTCGCACTCTGCCACCTCGCAGAGCTACACGCGGAGCAGGCT
  GTTTTGCTGCAGCTCTGAGTTGTTAAAGCACTGAGACGATTTCCGCCTATAGTCAGCCAC
  CGCCCAGTTATTGGATGTTTATTGTGTGAATCAAAAAAATAACAGGTTGGACAGAGAGCC
  ATTGAATTGATTG
• Restriction Sites: Please inquire
• ACCN: NM_016237
• ORF Size: 2268 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_016237.3, NP_057321.2
• RefSeq Size: 2490
• RefSeq ORF: 2268
• Locus ID: 51433
• Domains: TPR
• Protein Families: Druggable Genome
• Protein Pathways: Cell cycle, Oocyte meiosis, Progesterone-mediated oocyte maturation, Ubiquitin mediated proteolysis
• Gene Summary: This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008]
  Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).