BCCIP (NM_078468) Human Untagged Clone

CAT#: SC319236

BCCIP (untagged)-Human BRCA2 and CDKN1A interacting protein (BCCIP), transcript variant B

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: BCCIP
• Synonyms: TOK-1; TOK1
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_078468.1 GGGGGTGAGCGGCAACATGGCGTCCAGGTCTAAGCGGCGTGCCGTGGAAAGTGGGGTTCC
  GCAGCCGCCGGATCCCCCAGTCCAGCGCGACGAGGAAGAGGAAAAAGAAGTCGAAAATGA
  GGATGAAGACGATGATGACAGTGACAAGGAAAAGGATGAAGAGGACGAGGTCATTGACGA
  GGAAGTGAATATTGAATTTGAAGCTTATTCCCTATCAGATAATGATTATGACGGAATTAA
  GAAATTACTGCAGCAGCTTTTTCTAAAGGCTCCTGTGAACACTGCAGAACTAACAGATCT
  CTTAATTCAACAGAACCATATTGGGAGTGTGATTAAGCAAACGGATGTTTCAGAAGACAG
  CAATGATGATATGGATGAAGATGAGGTTTTTGGTTTCATAAGCCTTTTAAATTTAACTGA
  AAGAAAGGGTACCCAGTGTGTTGAACAAATTCAAGAGTTGGTTCTACGCTTCTGTGAGAA
  GAACTGTGAAAAGAGCATGGTTGAACAGCTGGACAAGTTTTTAAATGACACCACCAAGCC
  TGTGGGCCTTCTCCTAAGTGAAAGATTCATTAATGTCCCTCCACAGATCGCTCTGCCCAT
  GTACCAGCAGCTTCAGAAAGAACTGGCGGGGGCACACAGAACCAATAAGCCATGTGGGAA
  GTGCTACTTTTACCTTCTGATTAGTAAGACATTTGTGGAAGCAGAAAAAAACAATTCCAA
  AAAGAAACCTAGCAACAAAAAGAAAGCTGCGTTAATGTTTGCAAATGCAGAGGAAGAATT
  TTTCTATGAGAAGGCAATTCTCAAGTTCAACTACTCAGTGCAGGAGGAGAGCGACACTTG
  TCTGGGAGGCAAATGGTCTTTTGATGACGTACCAATGACGCCCTTGCGAACTGTGATGTT
  AATTCCAGGCGACAAGATGAACGAAATCATGGATAAACTGAAAGAATATCTATCTGTCTA
  ACCCATTTCCAATGGACAGTGATGGGCTTGTTTTTGTAAAATTACCAGAAAACTCAGTGG
  AGATTTACTGAAAAACTCAGACTTTATTCAGATTAAGTTCCTCTACAAAAAGTAGGGTTC
  TGTCCCATGTGTCTCTGACACATTTACAAAATACCAGTTTTTTAAAATTTTGGTCAAATT
  ATGAGTGGTTGATTTAAAAACTTTTCCAAGAAGAAGAAAAGCATGGAGTCGTAATTTAAA
  GAACTCAATAAAAACTTCTATTTTTTATTTTAAAATAATACCAAAAAAAAAAAAAAAAAA
  AAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_078468.1 unedited
  GGCGCTTGTATACGACTCCTATAGGGCGGCCGGGAATTCGGCCATTACGGCCGGGGGTGA
  GCGGCAACATGGCGTCCAGGTCTAAGCGGCGTGCCGTGGAAAGTGGGGTTCCGCAGCCGC
  CGGATCCCCCAGTCCAGCGCGACGAGGAAGAGGAAAAAGAAGTCGAAAATGAGGATGAAG
  ACGATGATGACAGTGACAAGGAAAAGGATGAAGAGGACGAGGTCATTGACGAGGAAGTGA
  ATATTGAATTTGAAGCTTATTCCCTATCAGATAATGATTATGACGGAATTAAGAAATTAC
  TGCAGCAGCTTTTTCTAAAGGCTCCTGTGAACACTGCAGAACTAACAGATCTCTTAATTC
  AACAGAACCATATTGGGAGTGTGATTAAGCAAACGGATGTTTCAGAAGACAGCAATGATG
  ATATGGATGAAGATGAGGTTTTTGGTTTCATAAGCCTTTTAAATTTAACTGAAAGAAAGG
  GTACCCAGTGTGTTGAACAAATTCAAGAGTTGGTTCTACGCTTCTGTGAGAAGAACTGTG
  AAAAGAGCATGGTTGAACAGCTGGACAAGTTTTTAAATGACACCACCAAGCCTGTGGGCC
  TTCTCCTAAGTGAAAGATTCATTAATGTCCCTCCACAGATCGCTCTGCCCATGTACCAGC
  AGCTTCAGAAAGAACTGGCGGGGGCACACAGAACCAATAAGCCATGTGGGAAGTGCTACT
  TTTACCTTCTGATTAGTAAGACATTTGTGGAAGCAGAAAAAAACAATTCCAAAAAGAAAC
  CTAGCAACAAAAGAAAGCTGCGTTAATGTTTGCAAATGCAGAGGAGATTTTTCTATGAGA
  GCAATTCTCAGTTCACTACTCAGTGCAGAGAGAGCGACACTTGTTCTGGAGGCAATGTCT
  TTTGATGACGTACCAATGACGCCTGGCGAACTTGTGGATGGTTTATTTCA
• Restriction Sites: Please inquire
• ACCN: NM_078468
• ORF Size: 945 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_078468.1, NP_510868.1
• RefSeq Size: 1268
• RefSeq ORF: 945
• Locus ID: 56647
• Protein Families: Druggable Genome, Stem cell - Pluripotency
• Gene Summary: This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (B) is alternatively spliced at the 3' end compared to transcript variant A. It encodes an isoform (BCCIPbeta) which has the same 258 N-terminal aa, but a different C-terminus compared to isoform BCCIPalpha.