SIRT2 (NM_030593) Human Untagged Clone

CAT#: SC319476

SIRT2 (untagged)-Human sirtuin 2 (SIRT2), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SIRT2
• Synonyms: SIR2; SIR2L; SIR2L2
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_030593.1 CGAAAGCGCGTCTGCGGCCGCAATGTCTGCTGAGAGTTGTAGTTCTGTGCCCTATCACGG
  CCACTCCCATTTCTGGTGCCGTCACGGGACAGAGCAGTCGGTGACAGGACAGAGCAGTCG
  GTGACGGGACACAGTGGTTGGTGACGGGACAGAGCGGTCGGTGACAGCCTCAAGGGCTTC
  AGCACCGCGCCCATGGCAGAGCCAGACCGACTCAGATTCAGACTCTGAGGGAGGAGCCGC
  TGGTGGAGAAGCAGACATGGACTTCCTGCGGAACTTATTCTCCCAGACGCTCAGCCTGGG
  CAGCCAGAAGGAGCGTCTGCTGGACGAGCTGACCTTGGAAGGGGTGGCCCGGTACATGCA
  GAGCGAACGCTGTCGCAGAGTCATCTGTTTGGTGGGAGCTGGAATCTCCACATCCGCAGG
  CATCCCCGACTTTCGCTCTCCATCCACCGGCCTCTATGACAACCTAGAGAAGTACCATCT
  TCCCTACCCAGAGGCCATCTTTGAGATCAGCTATTTCAAGAAACATCCGGAACCCTTCTT
  CGCCCTCGCCAAGGAACTCTATCCTGGGCAGTTCAAGCCAACCATCTGTCACTACTTCAT
  GCGCCTGCTGAAGGACAAGGGGCTACTCCTGCGCTGCTACACGCAGAACATAGATACCCT
  GGAGCGAATAGCCGGGCTGGAACAGGAGGACTTGGTGGAGGCGCACGGCACCTTCTACAC
  ATCACACTGCGTCAGCGCCAGCTGCCGGCACGAATACCCGCTAAGCTGGATGAAAGAGAA
  GATCTTCTCTGAGGTGACGCCCAAGTGTGAAGACTGTCAGAGCCTGGTGAAGCCTGATAT
  CGTCTTTTTTGGTGAGAGCCTCCCAGCGCGTTTCTTCTCCTGTATGCAGTCAGACTTCCT
  GAAGGTGGACCTCCTCCTGGTCATGGGTACCTCCTTGCAGGTGCAGCCCTTTGCCTCCCT
  CATCAGCAAGGCACCCCTCTCCACCCCTCGCCTGCTCATCAACAAGGAGAAAGCTGGCCA
  GTCGGACCCTTTCCTGGGGATGATTATGGGCCTCGGAGGAGGCATGGACTTTGACTCCAA
  GAAGGCCTACAGGGACGTGGCCTGGCTGGGTGAATGCGACCAGGGCTGCCTGGCCCTTGC
  TGAGCTCCTTGGATGGAAGAAGGAGCTGGAGGACCTTGTCCGGAGGGAGCACGCCAGCAT
  AGATGCCCAGTCGGGGGCGGGGGTCCCCAACCCCAGCACTTCAGCTTCCCCCAAGAAGTC
  CCCGCCACCTGCCAAGGACGAGGCCAGGACAACAGAGAGGGAGAAACCCCAGTGACAGCT
  GCATCTCCCAGGCGGGATGCCGAGCTCCTCAGGGACAGCTGAGCCCCAACCGGGCCTGGC
  CCCCTCTTAACCAGCAGTTCTTGTCTGGGGAGCTCAGAACATCCCCCAATCTCTTACAGC
  TCCCTCCCCAAAACTGGGGTCCCAGCAACCCTGGCCCCCAACCCCAGCAAATCTCTAACA
  CCTCCTAGAGGCCAAGGCTTAAACAGGCATCTCTACCAGCCCCACTGTCTCTAACCACTC
  CTGGGCTAAGGAGTAACCTCCCTCATCTCTAACTGCCCCCACGGGGCCAGGGCTACCCCA
  GAACTTTTAACTCTTCCAGGACAGGGAGCTTCGGGCCCCCACTCTGTCTCCTGCCCCCGG
  GGGCCTGTGGCTAAGTAAACCATACCTAACCTACCCCAGTGTGGGTGTGGGCCTCTGAAT
  ATAACCCACACCCAGCGTAGGGGGAGTCTGAGCCGGGAGGGCTCCCGAGTCTCTGCCTTC
  AGCTCCCAAAGTGGGTGGTGGGCCCCCTTCACGTGGGACCCACTTCCCATGCTGGATGGG
  CAGAAGACATTGCTTATTGGAGACAAATTAAAAACAAAAACAACTAACAAAAAAAAAAAA
  AAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_030593.1 unedited
  GACCTTTGTCATACGACTCCTATAGGGCGGCCGCGGAATTCGGCACGAGGCGAAAGCGCG
  TCTGCGGCCGCAATGTCTGCTGAGAGTTGTAGTTCTGTGCCCTATCACGGCCACTCCCAT
  TTCTGGTGCCGTCACGGGACAGAGCAGTCGGTGACAGGACAGAGCAGTCGGTGACGGGAC
  ACAGTGGTTGGTGACGGGACAGAGCGGTCGGTGACAGCCTCAAGGGCTTCAGCACCGCGC
  CCATGGCAGAGCCAGACCGACTCAGATTCAGACTCTGAGGGAGGAGCCGCTGGTGGAGAA
  GCAGACATGGACTTCCTGCGGAACTTATTCTCCCAGACGCTCAGCCTGGGCAGCCAGAAG
  GAGCGTCTGCTGGACGAGCTGACCTTGGAAGGGGTGGCCCGGTACATGCAGAGCGAACGC
  TGTCGCAGAGTCATCTGTTTGGTGGGAGCTGGAATCTCCACATCCGCAGGCATCCCCGAC
  TTTCGCTCTCCATCCACCGGCCTCTATGACAACCTAGAGAAGTACCATCTTCCCTACCCA
  GAGGCCATCTTTGAGATCAGCTATTTCAAGAAACATCCGGAACCCTTCTTCGCCCTCGCC
  AAGGAACTCTATCCTGGGCAGTTCAAGCCAACCATCTGTCACTACTTCATGCGCCTGCTG
  AAGGACAAGGGCTACTCCTGCGCTGCTACACGCAGAACATAGATACCCTGAGCGAATAGC
  CGGGCTGGAACAGGAGGACTTGGTGGAGGCGCACGGCACCTTCTACACATCACACTGCGT
  CAGCGCAGCTGCGGCACGATACCCGCTAAGCTGGATGAAGAGAGATCTTCTCTGAGGTGA
  CGCCAGTTGTGAAGACTGTCAGAGCCTGGTGGAGCCTGATATCGTCTTTTTTTGGTGGAA
  GAGCCCTCCCAGGCGCGTCTC
• Restriction Sites: Please inquire
• ACCN: NM_030593
• ORF Size: 1059 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_030593.1, NP_085096.1
• RefSeq Size: 1931
• RefSeq ORF: 1059
• Locus ID: 22933
• Domains: SIR2
• Protein Families: Druggable Genome, Transcription Factors
• Gene Summary: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]
  Transcript Variant: This variant (2) lacks an exon in the 5' region, resulting in a downstream in-frame AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 1.