LAT (NM_001014987) Human Untagged Clone

CAT#: SC319636

LAT (untagged)-Human linker for activation of T cells (LAT), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: LAT
• Synonyms: IMD52; LAT1; pp36
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_001014987.1 GGGCCTCCCTGCTCGCTGCCTCCCCGGGTCCTGGATATGGAGGCCACGGCTGCCAGCTGG
  CAGGTGGCTGTCCCCGTCTTGGGGGGGGCCAGCAGACCCTTGGGGCCTAGGGGTGCAGCC
  AGCCTGCTCCGAGCTCCCCTGCAGATGGAGGAGGCCATCCTGGTCCCCTGCGTGCTGGGG
  CTCCTGCTGCTGCCCATCCTGGCCATGTTGATGGCACTGTGTGTGCACTGCCACAGACTG
  CCAGGCTCCTACGACAGCACATCCTCAGATAGTTTGTATCCAAGGGGCATCCAGTTCAAA
  CGGCCTCACACGGTTGCCCCCTGGCCACCTGCCTACCCACCTGTCACCTCCTACCCACCC
  CTGAGCCAGCCAGACCTGCTCCCCATCCCAAGATCCCCGCAGCCCCTTGGGGGCTCCCAC
  CGGACGCCATCTTCCCGGCGGGATTCTGATGGTGCCAACAGTGTGGCGAGCTACGAGAAC
  GAGGAACCAGCCTGTGAGGATGCGGATGAGGATGAGGACGACTATCACAACCCAGGCTAC
  CTGGTGGTGCTTCCTGACAGCACCCCGGCCACTAGCACTGCTGCCCCATCAGCTCCTGCA
  CTCAGCACCCCTGGCATCCGAGACAGTGCCTTCTCCATGGAGTCCATTGATGATTACGTG
  AACGTTCCGGAGAGCGGGGAGAGCGCAGAAGCGTCTCTGGATGGCAGCCGGGAGTATGTG
  AATGTGTCCCAGGAACTGCATCCTGGAGCGGCTAAGACTGAGCCTGCCGCCCTGAGTTCC
  CAGGAGGCAGAGGAAGTGGAGGAAGAGGGGGCTCCAGATTACGAGAATCTGCAGGAGCTG
  AACTGAGGGCCTGTGGAGGCCGAGTCTGTCCTGGAACCAGGCTTGCCTGGGACGGCTGAG
  CTGGGCAGCTGGAAGTGGCTCTGGGGTCCTCACATGGCGTCCTGCCCTTGCTCCAGCCTG
  ACAACAGCCTGAGAAATCCCCCCGTAACTTATTATCACTTTGGGGTTCGGCCTGTGTCCC
  CCGAACGCTCTGCACCTTCTGACGCAGCCTGAGAATGACCTGCCCTGGCCCCAGCCCTAC
  TCTGTGTAATAGAATAAAGGCCTGCGTGTGTCTGTGTTGAGCGTGCGTCTGTGTGTGCCT
  GTGTGCGAGTCTGAGTCAGAGATTTGGAGATGTCTCTGTGTGTTTGTGTGTATCTGTGGG
  TCTCCATCCTCCATGGGGGCTCAGCCAGGTGCTGTGACACCCCCCTTCTGAATGAAGCCT
  TCTGACCTGGGCTGGCACTGCTGGGGGTGAGGACACATTGCCCCATGAGACAGTCCCAGA
  ACACGGCAGCTGCTGGCTGTGACAATGGTTTCACCATCCTTAGACCAAGGGATGGGACCT
  GATGACCTGGGAGGACTCTCTTAGTTCTTACCTTTTGTGGTTCTCAATAAAACAGAACTT
  AAAAAATTAAAAAAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_001014987.1 unedited
  ATCGTATACTTGTATACGACTCCTATAGGGCGGCCGGGAATTCGGCACGAGGGGGCCTCC
  CTGCTCGCTGCCTCCCCGGGTCCTGGATATGGAGGCCACGGCTGCCAGCTGGCAGGTGGC
  TGTCCCCGTCTTGGGGGGGGCCAGCAGACCCTTGGGGCCTAGGGGTGCAGCCAGCCTGCT
  CCGAGCTCCCCTGCAGATGGAGGAGGCCATCCTGGTCCCCTGCGTGCTGGGGCTCCTGCT
  GCTGCCCATCCTGGCCATGTTGATGGCACTGTGTGTGCACTGCCACAGACTGCCAGGCTC
  CTACGACAGCACATCCTCAGATAGTTTGTATCCAAGGGGCATCCAGTTCAAACGGCCTCA
  CACGGTTGCCCCCTGGCCACCTGCCTACCCACCTGTCACCTCCTACCCACCCCTGAGCCA
  GCCAGACCTGCTCCCCATCCCAAGATCCCCGCAGCCCCTTGGGGGCTCCCACCGGACGCC
  ATCTTCCCGGCGGGATTCTGATGGTGCCAACAGTGTGGCGAGCTACGAGAACGAGGAACC
  AGCCTGTGAGGATGCGGATGAGGATGAGGACGACTATCACAACCCAGGCTACCTGGTGGT
  GCTTCCTGACAGCACCCCGGCCACTAGCACTGCTGCCCCATCAGCTCCTGCACTCAGCAC
  CCCTGGCATCCGAGACAGTGCCTTCTCCATGGAGTCCATTGATGATTACGTGAACGTTCC
  GGAGAGCGGGGAGAGCGCAGAAGCGTCTCTGGATGGCAGCCGGGAGTATGTGAATGTGTC
  CCAGACTGCATCCTGGAGCGGCTAAGACTGAGCCTGCCGCCCTGGAGTTCCCAGAGCAGA
  GAGTGAGAGAGGGGGCTCAGAATTACGAGAATCTGCAGGAGCTGACTGAGGCTGTGGAGC
  GAGTTCTGTCTGGACAGCCTTGCTGGAACGCTGACCTGGCAGCTGGAATTGGCCTTCTTG
  GGGTTCCTT
• Restriction Sites: Please inquire
• ACCN: NM_001014987
• ORF Size: 702 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001014987.1, NP_001014987.1
• RefSeq Size: 1680
• RefSeq ORF: 702
• Locus ID: 27040
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway
• Gene Summary: The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (b) is shorter at the N-terminus compared to isoform d.