UBE1C (UBA3) (NM_003968) Human Untagged Clone

CAT#: SC319697

UBA3 (untagged)-Human ubiquitin-like modifier activating enzyme 3 (UBA3), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: UBA3
• Synonyms: hUBA3; NAE2; UBE1C
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_003968.3 GGGAGAGGCGGAGAACAATATGGCGGATGGCGAGGAGCCGGAGAGGAAAAGAAGGAGAAT
  AGAGGAGCTGCTGGCTGAGAAAATGGCTGTTGATGGTGGGTGTGGGGACACTGGAGACTG
  GGAAGGTCGCTGGAACCATGTAAAGAAGTTCCTCGAGCGATCTGGACCCTTCACACACCC
  TGATTTCGAACCGAGCACTGAATCTCTCCAGTTCTTGTTAGATACATGTAAAGTTCTAGT
  CATTGGAGCTGGCGGCTTAGGATGTGAGCTCCTGAAAAATCTGGCCTTGTCTGGTTTTAG
  ACAGATTCATGTTATAGATATGGACACTATAGATGTTTCCAATCTAAATAGGCAGTTTTT
  ATTTAGGCCTAAAGATATTGGAAGACCTAAGGCTGAAGTTGCTGCAGAATTTCTAAATGA
  CAGAGTTCCTAATTGCAATGTAGTTCCACATTTCAACAAGATTCAAGATTTTAACGACAC
  TTTCTATCGACAATTTCATATTATTGTATGTGGACTGGACTCTATCATCGCCAGAAGATG
  GATAAATGGCATGCTGATATCTCTTCTAAATTATGAAGATGGTGTCTTAGATCCAAGCTC
  CATTGTCCCTTTGATAGATGGGGGGACAGAAGGTTTTAAAGGAAATGCCCGGGTGATTCT
  GCCTGGAATGACTGCTTGTATCGAATGCACGCTGGAACTTTATCCACCACAGGTTAATTT
  TCCCATGTGCACCATTGCATCTATGCCCAGGCTACCAGAACACTGTATTGAGTATGTAAG
  GATGTTGCAGTGGCCTAAGGAGCAGCCTTTTGGAGAAGGGGTTCCATTAGATGGAGATGA
  TCCTGAACATATACAATGGATTTTCCAAAAATCCCTAGAGAGAGCATCACAATATAATAT
  TAGGGGTGTTACGTATAGGCTCACTCAAGGGGTAGTAAAAAGAATCATTCCTGCAGTAGC
  TTCCACAAATGCAGTCATTGCAGCTGTGTGTGCCACTGAGGTTTTTAAAATAGCCACAAG
  TGCATACATTCCCTTGAATAATTACTTGGTGTTTAATGATGTAGATGGGCTGTATACATA
  CACATTTGAAGCAGAAAGAAAGGAAAACTGCCCAGCTTGTAGCCAGCTTCCTCAAAATAT
  TCAGTTTTCTCCATCAGCTAAACTACAGGAGGTTTTGGATTATCTAACCAATAGTGCTTC
  TCTGCAAATGAAATCTCCAGCCATCACAGCCACCCTAGAGGGAAAAAATAGAACACTTTA
  CTTACAGTCGGTAACCTCTATTGAAGAACGAACAAGGCCAAATCTCTCCAAAACATTGAA
  AGAATTGGGGCTTGTTGATGGACAAGAACTGGCGGTTGCTGATGTCACCACCCCACAGAC
  TGTACTATTCAAACTTCATTTTACTTCTTAAGGAAAATCTCCACATAATAGAAAACTCAT
  GGAAATAATATACTTTGTGGATGCTAAGAAGTTGAATCGATGTCATTTTTAGCAATAGTG
  TTGCCACGATTTGTCTTTTTTTTATATAATGAACCACTCTTTTTTAACTTTGTAACCTTC
  CCTTGAAGACAGAATTTTGGTGTTGGTGCTTGTAAGCATTTTCATTAATAATATGAGAAA
  TGATACCTGGAGAGAGAGATTATGAGCAAATGTATTGCTTCTTTTAGAGGAGGAAGCATA
  CAACCTCTTTTGTGTGAATTTTGTTATTATGGTCAAAGAATGCATTCCTAAGTTTTCATT
  TGAGTACCCAAATACACAAAAGGTGTCCCTTTAAGGAAAATAAAGAATTAAGTTTTAAAT
  CAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003968.3 unedited
  AGGACGAGCATGATGTGTTCTTAACTGCTCTAGGGCGGCCGGAATCGGCCATTACGGCCG
  GGAGAGGCGGAGAACAATATGGCGGATGGCGAGGAGCCGGAGAGGAAAAGAAGGAGAATA
  GAGGAGCTGCTGGCTGAGAAAATGGCTGTTGATGGTGGGTGTGGGGACACTGGAGACTGG
  GAAGGTCGCTGGAACCATGTAAAGAAGTTCCTCGAGCGATCTGGACCCTTCACACACCCT
  GATTTCGAACCGAGCACTGAATCTCTCCAGTTCTTGTTAGATACATGTAAAGTTCTAGTC
  ATTGGAGCTGGCGGCTTAGGATGTGAGCTCCTGAAAAATCTGGCCTTGTCTGGTTTTAGA
  CAGATTCATGTTATAGATATGGACACTATAGATGTTTCCAATCTAAATAGGCAGTTTTTA
  TTTAGGCCTAAAGATATTGGAAGACCTAAGGCTGAAGTTGCTGCAGAATTTCTAAATGAC
  AGAGTTCCTAATTGCAATGTAGTTCCACATTTCAACAAGATTCAAGATTTTAACGACACT
  TTCTATCGACAATTTCATATTATTGTATGTGGACTGGACTCTATCATCGCCAGAAGATGG
  ATAAATGGCATGCTGATATCTCTTCTAAATTATGAAGATGGTGTCTTAGATCCAAGCTCC
  ATTGTCCCTTTGATAGATGGGGGGACAGAAGTTTTAAAGGAAATGCCCGGTGATTCTGCC
  TGGAATGACTGCTTGTATCGAATGCACGCTGGAACTTTATCCACCACAGGTTAATTTTCC
  ATGTCACATTGCATTCTATGCCCAGCTACCAGACACTGATTGATATTGTAAGATGTTGCA
  TGGCTACGAGCAGCTTTGGAGAGGTTCCATAGAATGGAGAAGATCCTGACATATAAAATG
  GATTTTCAAAATCCCTAAGA
• Restriction Sites: Please inquire
• ACCN: NM_003968
• ORF Size: 1392 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_003968.3, NP_003959.3
• RefSeq Size: 2136
• RefSeq ORF: 1392
• Locus ID: 9039
• Domains: UBACT, ThiF
• Protein Pathways: Ubiquitin mediated proteolysis
• Gene Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (1) encodes the longer isoform (1).