Thyroxine Binding Globulin (SERPINA7) (NM_000354) Human Untagged Clone

CAT#: SC319930

SERPINA7 (untagged)-Human serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 (SERPINA7)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SERPINA7
• Synonyms: TBG; TBGQTL
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_000354.3 TTAACTTCCTTCCAAAATGTCACCATTCCTGTATCTGGTTCTCTTGGTACTTGGGCTTCA
  TGCTACAATCCACTGTGCATCACCTGAAGGCAAAGTAACAGCCTGCCATTCATCCCAACC
  AAATGCCACTCTCTACAAGATGTCATCCATTAATGCTGACTTTGCATTCAATCTGTACCG
  GAGGTTCACTGTGGAGACCCCAGATAAGAACATCTTCTTTTCCCCTGTGAGCATTTCTGC
  AGCTTTGGTTATGCTTTCCTTTGGGGCCTGCTGCAGCACCCAAACTGAGATTGTGGAGAC
  CTTGGGGTTCAACCTCACAGACACTCCAATGGTAGAGATCCAGCATGGCTTCCAGCATCT
  GATCTGTTCACTGAATTTTCCAAAGAAGGAACTGGAATTGCAGATAGGAAATGCCCTCTT
  CATTGGCAAGCATCTGAAACCACTGGCAAAGTTCTTGAATGATGTCAAGACCCTCTATGA
  GACTGAAGTCTTTTCTACCGACTTCTCCAACATTTCTGCAGCCAAGCAGGAGATTAACAG
  TCATGTGGAGATGCAAACCAAAGGGAAAGTTGTGGGTCTAATTCAAGACCTCAAGCCAAA
  CACCATCATGGTCTTAGTGAACTATATTCACTTTAAAGCCCAGTGGGCAAATCCTTTTGA
  TCCATCCAAGACAGAAGACAGTTCCAGCTTCTTAATAGACAAGACCACCACTGTTCAAGT
  GCCCATGATGCACCAGATGGAACAATACTATCACCTAGTGGATATGGAATTGAACTGCAC
  AGTTCTGCAAATGGACTACAGCAAGAATGCTCTGGCACTCTTTGTTCTTCCCAAGGAGGG
  ACAGATGGAGTCAGTGGAAGCTGCCATGTCATCTAAAACACTGAAGAAGTGGAACCGCTT
  ACTACAGAAGGGATGGGTTGACTTGTTTGTTCCAAAGTTTTCCATTTCTGCCACATATGA
  CCTTGGAGCCACACTTTTGAAGATGGGCATTCAGCATGCCTATTCTGAAAATGCTGATTT
  TTCTGGACTCACAGAGGACAATGGTCTGAAACTTTCCAATGCTGCCCATAAGGCTGTGCT
  GCACATTGGTGAAAAGGGAACTGAAGCTGCAGCTGTCCCTGAAGTTGAACTTTCGGATCA
  GCCTGAAAACACTTTCCTACACCCTATTATCCAAATTGATAGATCTTTCATGTTGTTGAT
  TTTGGAGAGAAGCACAAGGAGTATTCTCTTTCTAGGGAAAGTTGTGAACCCAACGGAAGC
  GTAGTTGGGAAAAAGGCCATTGGCTAATTGCACGTGTGTATTGCAATGGGAAATAAATAA
  ATAATATAGCCTGGTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
• Restriction Sites: Please inquire
• ACCN: NM_000354
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_000354.3, NP_000345.1
• RefSeq Size: 1559 bp
• RefSeq ORF: 1248 bp
• Locus ID: 6906
• Cytogenetics: Xq22.3
• Domains: SERPIN
• Protein Families: Druggable Genome, Secreted Protein
• Gene Summary: 'There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.[provided by RefSeq, Jun 2012]'