PSMB8 (NM_004159) Human Untagged Clone

CAT#: SC320228

PSMB8 (untagged)-Human proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) (PSMB8), transcript variant 1


  "NM_004159" in other vectors (6)

Reconstitution Protocol

USD 660.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol PSMB8
Synonyms ALDD; D6S216; D6S216E; JMP; LMP7; NKJO; PRAAS1; PSMB5i; RING10
Vector pCMV6-AC
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
>OriGene sequence for NM_004159.4 AGCAACGCTAGGAAGGGCGGGCAGAAAGGGCACGCTCTTGTGGGTGACTACAGGTTAGGA
GACCGTTGAACCTGGAGGGGCCCTAGGATGGACCCCGTGGAAAGATTCAGAGACTGCGCC
CTCTCCCTGGCGCCGCCTTCCCCTACACGCGGCGGGTATATTCTGTTGCAGTTGGCCCAG
GACCTGTTTCCAAGACTCTGCCCCCTCGCACTTCCGTCCCTCCTGGTTTTGTAAAGTGAT
GCTCATAGGAACCCCCACCCCGCGTGACACTACTCCCAGCTCCTGGCTGACTTCTAGTCT
TCTGGTTGAAGCTGCGCCTTTAGATGACACGACCCTACCCACCCCTGTTTCCAGCGGATG
CCCGGGCCTGGAGCCCACAGAATTCTTCCAGTCCCTGGGTGGGGACGGAGAAAGGAACGT
TCAGATTGAGATGGCCCATGGCACCACCACGCTCGCCTTCAAGTTCCAGCATGGAGTGAT
TGCAGCAGTGGATTCTCGGGCCTCAGCTGGGTCCTACATTAGTGCCTTACGGGTGAACAA
GGTGATTGAGATTAACCCTTACCTGCTTGGCACCATGTCTGGCTGTGCAGCAGACTGTCA
GTACTGGGAGCGCCTGCTGGCCAAGGAATGCAGGCTGTACTATCTGCGAAATGGAGAACG
TATTTCAGTGTCGGCAGCCTCCAAGCTGCTGTCCAACATGATGTGCCAGTACCGGGGCAT
GGGCCTCTCTATGGGCAGTATGATCTGTGGCTGGGATAAGAAGGGTCCTGGACTCTACTA
CGTGGATGAACATGGGACTCGGCTCTCAGGAAATATGTTCTCCACGGGTAGTGGGAACAC
TTATGCCTACGGGGTCATGGACAGTGGCTATCGGCCTAATCTTAGCCCTGAAGAGGCCTA
TGACCTTGGCCGCAGGGCTATTGCTTATGCCACTCACAGAGACAGCTATTCTGGAGGCGT
TGTCAATATGTACCACATGAAGGAAGATGGTTGGGTGAAAGTAGAAAGTACAGATGTCAG
TGACCTGCTGCACCAGTACCGGGAAGCCAATCAATAATGGTGGTGGTGGCAGCTGGGCAG
GTCTCCTCTGGGAGGTCTTGGCCGACTCAGGGACCTAAGCCACGTTAAGTCCAAGGAGAA
GAAGAGGCCTAGCCTGAGCCAAAGAGAGAGTACGGGCTCAGCAGCCAGAGGAGGCCGGTG
AAGTGCATCTTCTGCGTGTTCTCTATTTGAACAAGCATTTCCCCCAGGGAAGTTTCTGGG
TGCCCCACTAAGTAGAATAAAGAAAAACGGTTATAAATAAAAAAAAAAAAAAAAAAAA
Restriction Sites Please inquire     
ACCN NM_004159
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_004159.4, NP_004150.1
RefSeq Size 1602 bp
RefSeq ORF 819 bp
Locus ID 5696
Cytogenetics 6p21.32
Protein Families Druggable Genome, Protease
Protein Pathways Proteasome
Gene Summary 'The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit. [provided by RefSeq, Jul 2008]'
Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (E1).

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