PAPSS2 (NM_004670) Human Untagged Clone

CAT#: SC320301

PAPSS2 (untagged)-Human 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPSS2), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PAPSS2
• Synonyms: ATPSK2; BCYM4; SK2
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_004670.3 GTCCGGCAGCCGCTGCTGCTGCTGCTGCTGCTGCTGCCGCCGCCGCCGCCGCCGTCCCTG
  CGTCCTTCGGTCTCTGCTCCCGGGACCCGGGCTCCGCCGCAGCCAGCCAGCATGTCGGGG
  ATCAAGAAGCAAAAGACGGAGAACCAGCAGAAATCCACCAATGTAGTCTATCAGGCCCAC
  CATGTGAGCAGGAATAAGAGAGGGCAAGTGGTTGGAACAAGGGGTGGGTTCCGAGGATGT
  ACCGTGTGGCTAACAGGTCTCTCTGGTGCTGGAAAAACAACGATAAGTTTTGCCCTGGAG
  GAGTACCTTGTCTCCCATGCCATCCCTTGTTACTCCCTGGATGGGGACAATGTCCGTCAT
  GGCCTTAACAGAAATCTCGGATTCTCTCCTGGGGACAGAGAGGAAAATATCCGCCGGATT
  GCTGAGGTGGCTAAGCTGTTTGCTGATGCTGGTCTGGTCTGCATTACCAGCTTTATTTCT
  CCATTCGCAAAGGATCGTGAGAATGCCCGCAAAATACATGAATCAGCAGGGCTGCCATTC
  TTTGAAATATTTGTAGATGCACCTCTAAATATTTGTGAAAGCAGAGACGTAAAAGGCCTC
  TATAAAAGGGCCAGAGCTGGGGAGATTAAAGGATTTACAGGTATTGATTCTGATTATGAG
  AAACCTGAAACTCCTGAGCGTGTGCTTAAAACCAATTTGTCCACAGTGAGTGACTGTGTC
  CACCAGGTAGTGGAACTTCTGCAAGAGCAGAACATTGTACCCTATACTATAATCAAAGAT
  ATCCACGAACTCTTTGTGCCGGAAAACAAACTTGACCACGTCCGAGCTGAGGCTGAAACT
  CTCCCTTCATTATCAATTACTAAGCTGGATCTCCAGTGGGTCCAGGTTTTGAGCGAAGGC
  TGGGCCACTCCCCTCAAAGGTTTCATGCGGGAGAAGGAGTACTTACAGGTTATGCACTTT
  GACACCCTGCTAGATGATGGCGTGATCAACATGAGCATCCCCATTGTACTGCCCGTCTCT
  GCAGAGGATAAGACACGGCTGGAAGGGTGCAGCAAGTTTGTCCTGGCACATGGTGGACGG
  AGGGTAGCTATCTTACGAGACGCTGAATTCTATGAACACAGAAAAGAGGAACGCTGTTCC
  CGTGTTTGGGGGACAACATGTACAAAACACCCCCATATCAAAATGGTGATGGAAAGTGGG
  GACTGGCTGGTTGGTGGAGACCTTCAGGTGCTGGAGAAAATAAGATGGAATGATGGGCTG
  GACCAATACCGTCTGACACCTCTGGAGCTCAAACAGAAATGTAAAGAAATGAATGCTGAT
  GCGGTGTTTGCATTCCAGTTGCGCAATCCTGTCCACAATGGCCATGCCCTGTTGATGCAG
  GACACTCGCCGCAGGCTCCTAGAGAGGGGCTACAAGCACCCGGTCCTCCTACTACACCCT
  CTGGGCGGCTGGACCAAGGATGACGATGTGCCTCTAGACTGGCGGATGAAGCAGCACGCG
  GCTGTGCTCGAGGAAGGGGTCCTGGATCCCAAGTCAACCATTGTTGCCATCTTTCCGTCT
  CCCATGTTATATGCTGGCCCCACAGAGGTCCAGTGGCACTGCAGGTCCCGGATGATTGCG
  GGTGCCAATTTCTACATTGTGGGGAGGGACCCTGCAGGAATGCCCCATCCTGAAACCAAG
  AAGGATCTGTATGAACCCACTCATGGGGGCAAGGTCTTGAGCATGGCCCCTGGCCTCACC
  TCTGTGGAAATCATTCCATTCCGAGTGGCTGCCTACAACAAAGCCAAAAAAGCCATGGAC
  TTCTATGATCCAGCAAGGCACAATGAGTTTGACTTCATCTCAGGAACTCGAATGAGGAAG
  CTCGCCCGGGAAGGAGAGAATCCCCCAGATGGCTTCATGGCCCCCAAAGCATGGAAGGTC
  CTGACAGATTATTACAGGTCCCTGGAGAAGAACTAAGCCTTTGGCTCCAGAGTTTCTTTC
  TGAAGTGCTCTTTGATTACCTTTTCTATTTTTATGATTAGATGCTTTGTATTAAATTGCT
  TCTCAATGATGCATTTTAATCTTTTATAATGAAGTAAAAGTTGTGTCTATAATTAAAAAA
  AAATATATATATATACACACACACATATACATACAAAGTCAAACTGAAGACCAAATCTTA
  GCAGGTAAAAGCAATATTCTTATACATTTCATAATAAAATTAGCTCTATGTATTTTCTAC
  TGCACCTGAGCAGGCAGGTCCCAGATTTCTTAAGGCTTTGTTTGACCATGTGTCTAGTTA
  CTTGCTGAAAAGTGAATATATTTTCCAGCATGTCTTGACAACCTGTACTCTTCCAATGTC
  ATTTATCAGTTGTAAAATATATCAGATTGTGTCCTCTTCTGTACAATTGACAAAAAAAAA
  AAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_004670.3 unedited
  GTACGTTTGTATACGACTCCTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCG
  AGGAGATCTGCCGCCGCGATCGCGGCGCGCCAGATCTCAAGCTTAACTAGTTAGCGGACC
  GACGCGTTAAGCGGCCGCGAATTCAGATCCACAAGTTTGTACAAAAAAGCAGGCTTGTAA
  AACGACGGCCAGTAACTATAACGGTCCTAAGGTAGCGAGGCCTGGGTGGCGAATTCGGCA
  CGAGGGTCCGGCAGCCGCTGCTGCTGCTGCTGCTGCTGCTGCCGCCGCCGCCGCCGCCGT
  CCCTGCGTCCTTCGGTCTCTGCTCCCGGGACCCGGGCTCCGCCGCAGCCAGCCAGCATGT
  CGGGGATCAAGAAGCAAAAGACGGAGAACCAGCAGAAATCCACCAATGTAGTCTATCAGG
  CCCACCATGTGAGCAGGAATAAGAGAGGGCAAGTGGTTGGAACAAGGGGTGGGTTCCGAG
  GATGTACCGTGTGGCTAACAGGTCTCTCTGGTGCTGGAAAAACAACGATAAGTTTTGCCC
  TGGAGGAGTACCTTGTCTCCCATGCCATCCCTTGTTACTCCCTGGATGGGGACAATGTCC
  GTCATGGCCTTAACAGAAATCTCGGATTCTCTCCTGGGGACAGAGAGGAAAATATCCGCC
  GGATTGCTGAGTGGCTAAGCTGTTTGCTGATGCTGGTCTGGTCTGCATTACCAGCTTTAT
  TTCTCCATTCGCAAAGGATCGTGAGAATGCCCGCAAAATACATGAATCAGCAGGGCTGCC
  ATTCTTTGAAATATTTGTAGATGCACCTCTAATATTTGTGAAAGCAGAGACGTAAAAGCC
  TCTATAAAAGGGCCAGAGCTGGGGAGATTAAAGATTACAGGTATTGAATCTGATATGGAA
  TCTGAACTCTGGAGCGTGTGCCTAAAACATTGGTCCAAGTGAGTGACTGGTCCACCAGTA
  TGCACTTCTGCAAGAAGACAGAAACATTGTTAC
• Restriction Sites: Please inquire
• ACCN: NM_004670
• ORF Size: 1845 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_004670.3, NP_004661.2
• RefSeq Size: 3859
• RefSeq ORF: 1845
• Locus ID: 9060
• Domains: ATP-sulfurylase, APS_kinase
• Protein Families: Druggable Genome
• Protein Pathways: Metabolic pathways, Purine metabolism, Selenoamino acid metabolism, Sulfur metabolism
• Gene Summary: Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (1) represents the more frequently occurring transcript. It encodes isoform a, which has also been named PAPS synthase 2a.