BACE2 (NM_012105) Human Untagged Clone

CAT#: SC320428

BACE2 (untagged)-Human beta-site APP-cleaving enzyme 2 (BACE2), transcript variant a

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: BACE2
• Synonyms: AEPLC; ALP56; ASP1; ASP21; BAE2; CDA13; CEAP1; DRAP
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_012105.3 GCCCCGCGCGCCGGCCGAGTCGCTGAGCCGCGGCTGCCGGACGGGACGGGACCGGCTAGG
  CTGGGCGCGCCCCCCGGGCCCCGCCGTGGGCATGGGCGCACTGGCCCGGGCGCTGCTGCT
  GCCTCTGCTGGCCCAGTGGCTCCTGCGCGCCGCCCCGGAGCTGGCCCCCGCGCCCTTCAC
  GCTGCCCCTCCGGGTGGCCGCGGCCACGAACCGCGTAGTTGCGCCCACCCCGGGACCCGG
  GACCCCTGCCGAGCGCCACGCCGACGGCTTGGCGCTCGCCCTGGAGCCTGCCCTGGCGTC
  CCCCGCGGGCGCCGCCAACTTCTTGGCCATGGTAGACAACCTGCAGGGGGACTCTGGCCG
  CGGCTACTACCTGGAGATGCTGATCGGGACCCCCCCGCAGAAGCTACAGATTCTCGTTGA
  CACTGGAAGCAGTAACTTTGCCGTGGCAGGAACCCCGCACTCCTACATAGACACGTACTT
  TGACACAGAGAGGTCTAGCACATACCGCTCCAAGGGCTTTGACGTCACAGTGAAGTACAC
  ACAAGGAAGCTGGACGGGCTTCGTTGGGGAAGACCTCGTCACCATCCCCAAAGGCTTCAA
  TACTTCTTTTCTTGTCAACATTGCCACTATTTTTGAATCAGAGAATTTCTTTTTGCCTGG
  GATTAAATGGAATGGAATACTTGGCCTAGCTTATGCCACACTTGCCAAGCCATCAAGTTC
  TCTGGAGACCTTCTTCGACTCCCTGGTGACACAAGCAAACATCCCCAACGTTTTCTCCAT
  GCAGATGTGTGGAGCCGGCTTGCCCGTTGCTGGATCTGGGACCAACGGAGGTAGTCTTGT
  CTTGGGTGGAATTGAACCAAGTTTGTATAAAGGAGACATCTGGTATACCCCTATTAAGGA
  AGAGTGGTACTACCAGATAGAAATTCTGAAATTGGAAATTGGAGGCCAAAGCCTTAATCT
  GGACTGCAGAGAGTATAACGCAGACAAGGCCATCGTGGACAGTGGCACCACGCTGCTGCG
  CCTGCCCCAGAAGGTGTTTGATGCGGTGGTGGAAGCTGTGGCCCGCGCATCTCTGATTCC
  AGAATTCTCTGATGGTTTCTGGACTGGGTCCCAGCTGGCGTGCTGGACGAATTCGGAAAC
  ACCTTGGTCTTACTTCCCTAAAATCTCCATCTACCTGAGAGATGAGAACTCCAGCAGGTC
  ATTCCGTATCACAATCCTGCCTCAGCTTTACATTCAGCCCATGATGGGGGCCGGCCTGAA
  TTATGAATGTTACCGATTCGGCATTTCCCCATCCACAAATGCGCTGGTGATCGGTGCCAC
  GGTGATGGAGGGCTTCTACGTCATCTTCGACAGAGCCCAGAAGAGGGTGGGCTTCGCAGC
  GAGCCCCTGTGCAGAAATTGCAGGTGCTGCAGTGTCTGAAATTTCCGGGCCTTTCTCAAC
  AGAGGATGTAGCCAGCAACTGTGTCCCCGCTCAGTCTTTGAGCGAGCCCATTTTGTGGAT
  TGTGTCCTATGCGCTCATGAGCGTCTGTGGAGCCATCCTCCTTGTCTTAATCGTCCTGCT
  GCTGCTGCCGTTCCGGTGTCAGCGTCGCCCCCGTGACCCTGAGGTCGTCAATGATGAGTC
  CTCTCTGGTCAGACATCGCTGGAAATGAATAGCCAGGCCTGACCTCAAGCAACCATGAAC
  TCAGCTATTAAGAAAATCACATTTCCAGGGCAGCAGCCGGGATCGATGGTGGCGCTTTCT
  CCTGTGCCCACCCGTCTTCAATCTCTGTTCTGCTCCCAGATGCCTTCTAGATTCACTGTC
  TTTTGATTCTTGATTTTCAAGCTTTCAAATCCTCCCTACTTCCAAGAAAAAAAAAAAAAA
  AAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_012105.3 unedited
  CGACTACTGACGATATGTGTGACTACTTACTGGACGCGGCTGGCCGGGAATTCGTCGACT
  GGATCCGGTACCGAGGAGTAGCTTAACTAGTTAGCGGACCGACGCGTTAAGCGGCCGCGA
  ATTCAGATCCACAAGTTTGTACAAAAAAGCAGGCTTGTAAAACGACGGCCAGTAACTATA
  ACGGTCCTAAGGTAGCGAGGCCTGGGTGGCGAATTCGGCACGAGGGCCCCGCGCGCCGGC
  CGAGTCGCTGAGCCGCGGCTGCCGGACGGGACGGGACCGGCTAGGCTGGGCGCGCCCCCC
  GGGCCCCGCCGTGGGCATGGGCGCACTGGCCCGGGCGCTGCTGCTGCCTCTGCTGGCCCA
  GTGGCTCCTGCGCGCCGCCCCGGAGCTGGCCCCCGCGCCCTTCACGCTGCCCCTCCGGGT
  GGCCGCGGCCACGAACCGCGTAGTTGCGCCCACCCCGGGACCCGGGACCCCTGCCGAGCG
  CCACGCCGACGGCTTGGCGCTCGCCCTGGAGCCTGCCCTGGCGTCCCCCGCGGGCGCCGC
  CAACTTCTTGGCCATGGTAGACAACCTGCAGGGGGACTCTGGCCGCGGCTACTACCTGGA
  GATGCTGATCGGGACCCCCCCGCAGAAGCTACAGATTCTCGTTGACACTGGAAGCAGTAA
  CTTTGCCGTGGCAGGAACCCCGCACTCCTACATAGACACGTACTTTGACACAGAGAGGTC
  TAGCACATACCGCTCCAAGGGCTTTGACGTCACAGTGAAGTACACACAAGAAGCTGGACG
  GGCTTCGTTGGGGAAGACCTCGTCACCATCCCCAAAGCTTCAATACTTCTTTTCTTGTCA
  CATTGCCACTATTTTTGATCAAGAATTTCTTTTGCTGGATTAAATGCATGAATACTGCCT
  AGCTATGCCAACTGCAGGCATCAGGTTCTCTGGAAAACCTTCTTCGCACTCCCTGTGTG
• Restriction Sites: Please inquire
• ACCN: NM_012105
• ORF Size: 1557 bp
• Insert Size: 2000
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_012105.3, NP_036237.2
• RefSeq Size: 2993
• RefSeq ORF: 1557
• Locus ID: 25825
• Domains: asp
• Protein Families: Druggable Genome, Protease, Transmembrane
• Protein Pathways: Alzheimer's disease
• Gene Summary: This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
  Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (A). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.