EXOSC6 (NM_058219) Human Untagged Clone

CAT#: SC320513

EXOSC6 (untagged)-Human exosome component 6 (EXOSC6)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: EXOSC6
• Synonyms: EAP4; hMtr3p; MTR3; Mtr3p; p11
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_058219.2 GCGGAAGGGGTTCGCACGCCAAGAACCGCCATGCCTGGGGATCACCGCCGCATCCGCGGC
  CCTGAAGAATCGCAGCCGCCGCAGCTGTACGCGGCCGACGAGGAGGAGGCGCCCGGCACC
  CGCGACCCAACGCGGCTACGGCCCGTGTACGCGCGCGCCGGGCTGCTGAGCCAGGCCAAG
  GGCTCGGCCTACCTGGAGGCGGGAGGCACCAAGGTGCTGTGTGCCGTGTCGGGCCCGCGA
  CAGGCCGAGGGCGGCGAGCGCGGCGGCGGCCCGGCCGGAGCAGGCGGCGAGGCCCCGGCC
  GCGCTGCGCGGTCGCCTGCTCTGCGACTTCCGCCGCGCACCCTTCGCGGGCCGCCGGCGC
  CGCGCTCCCCCGGGCGGCTGCGAGGAGCGTGAGCTGGCGCTGGCGCTGCAGGAGGCGCTG
  GAGCCGGCTGTGCGCCTGGGCCGCTACCCGCGCGCGCAGCTCGAGGTGTCGGCGCTGCTG
  CTGGAGGACGGTGGCTCGGCCCTGGCCGCCGCGCTCACCGCCGCCGCGCTCGCCCTGGCC
  GACGCGGGCGTGGAGATGTACGACCTGGTGGTGGGCTGCGGCCTCAGCCTCGCGCCGGGG
  CCCGCGCCCACCTGGCTCCTGGACCCCACGCGGCTCGAGGAAGAGCGCGCCGCCGCCGGC
  CTCACCGTGGCGCTCATGCCTGTGCTGAATCAGGTGGCCGGGCTGCTGGGCAGCGGCGAG
  GGCGGCCTGACAGAGAGCTGGGCGGAGGCCGTACGCCTGGGCCTCGAGGGCTGCCAGCGC
  CTCTACCCCGTGCTGCAGCAGAGCCTGGTGCGGGCCGCCCGCCGCAGGGGCGCCGCCGCC
  CAGCCCTGAACCAGAAGCCTGAGCAACTACGGACGCAAGCCGAGGACCGTGCTGCCGCCG
  TCCACGAAAAGACCCGCGCCATCGGCCTCCAGTTTGCGTCGAGAATTCCTGGAAGGGCCC
  TGATATGACTGTGGTTGGACTGACCTGACTGCCAGATGGTGGGACTTGGTCTGGAGCAGG
  GACTACTTGGAATGATAAAGGCAAAACTCAACAGCCCCTGGAGCTGCGCTTGTGGTGGAG
  CTGGACCCTGAAATTACCTGGACCTTTTTTTTAGAGACAGGGTTTCTTTCTGCAGTCTCA
  AACTCCTAGCCTTGATTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGACTACAGGTG
  CATGCAACCACACCTGGCTAATTTTCTTTTCTTCTTTCTTTCTTTTTTTTTTTTTTTTTT
  TTTTGATGGAGTCTTGTTCTGTTGCCCAGGCTGGAGTGCAATGGTGCAATCTTGGCTCAC
  TGCAACCTCTGCCTCCTGGGTTCAATCCATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGG
  ATTACAGGCACATGCCTCCATACCGGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTT
  CGCCATGTGGGCCAGGCTGTTCTCGAATGCCTGACCTCAGGTGATCCACCCGCCTTGGCC
  TCCCAAAGTGCTGGAATTACAGGTGTGAGCCACTGTGCCCAGCTGAGTAAATTTCTTGAT
  TGCACAGAATGTACGGTGATATTGGCGGACTTAAGGACATCGAATTGTTTATCAGGAATA
  AAGTATTATGTGTGTTTTCTGCGGCCCTGGATAATGCTGTAGCATTCAGGGTCGATTGAG
  TAAAAAAAATGTAGAGATGGAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_058219.2 unedited
  AAGACTACTGCGTATATTTCCGGACTGGAGTCACCCGGTTCGGGAATTCGTCGACTGGAT
  CCGGTACCGAGGAGATCTGCACTAGTTAGCGGACCGACGCGTTAAGCGGCCGCGAATTCA
  GATCCACAAGTTTGTACAAAAAAGCAGGCTTGTAAAACGACGGCCAGTAACTATAACGGT
  CCTAAGGTAGCGAGGCCTGGGTGGCGAATTCGGCACGAGGGCGGAAGGGGTTCGCACGCC
  AAGAACCGCCATGCCTGGGGATCACCGCCGCATCCGCGGCCCTGAAGAATCGCAGCCGCC
  GCAGCTGTACGCGGCCGACGAGGAGGAGGCGCCCGGCACCCGCGACCCAACGCGGCTACG
  GCCCGTGTACGCGCGCGCCGGGCTGCTGAGCCAGGCCAAGGGCTCGGCCTACCTGGAGGC
  GGGAGGCACCAAGGTGCTGTGTGCCGTGTCGGGCCCGCGACAGGCCGAGGGCGGCGAGCG
  CGGCGGCGGCCCGGCCGGAGCAGGCGGCGAGGCCCCGGCCGCGCTGCGCGGTCGCCTGCT
  CTGCGACTTCCGCCGCGCACCCTTCGCGGGCCGCC
• Restriction Sites: Please inquire
• ACCN: NM_058219
• ORF Size: 819 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_058219.2, NP_478126.1
• RefSeq Size: 1729
• RefSeq ORF: 819
• Locus ID: 118460
• Domains: RNase_PH_C
• Protein Pathways: RNA degradation
• Gene Summary: This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation. [provided by RefSeq, Jul 2008]