Claudin 8 (CLDN8) (NM_199328) Human Untagged Clone

CAT#: SC320974

CLDN8 (untagged)-Human claudin 8 (CLDN8)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CLDN8
• Synonyms: HEL-S-79
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_199328.1 GGGACAGAGAACCCTGCTTCAAAGCAGAAGTAGCAGTTCCGGAGTCCAGCTGGCTAAAAC
  TCATCCCAGAGGATAATGGCAACCCATGCCTTAGAAATCGCTGGGCTGTTTCTTGGTGGT
  GTTGGAATGGTGGGCACAGTGGCTGTCACTGTCATGCCTCAGTGGAGAGTGTCGGCCTTC
  ATTGAAAACAACATCGTGGTTTTTGAAAACTTCTGGGAAGGACTGTGGATGAATTGCGTG
  AGGCAGGCTAACATCAGGATGCAGTGCAAAATCTATGATTCCCTGCTGGCTCTTTCTCCG
  GACCTACAGGCAGCCAGAGGACTGATGTGTGCTGCTTCCGTGATGTCCTTCTTGGCTTTC
  ATGATGGCCATCCTTGGCATGAAATGCACCAGGTGCACGGGGGACAATGAGAAGGTGAAG
  GCTCACATTCTGCTGACGGCTGGAATCATCTTCATCATCACGGGCATGGTGGTGCTCATC
  CCTGTGAGCTGGGTTGCCAATGCCATCATCAGAGATTTCTATAACTCAATAGTGAATGTT
  GCCCAAAAACGTGAGCTTGGAGAAGCTCTCTACTTAGGATGGACCACGGCACTGGTGCTG
  ATTGTTGGAGGAGCTCTGTTCTGCTGCGTTTTTTGTTGCAACGAAAAGAGCAGTAGCTAC
  AGATACTCGATACCTTCCCATCGCACAACCCAAAAAAGTTATCACACCGGAAAGAAGTCA
  CCGAGCGTCTACTCCAGAAGTCAGTATGTGTAGTTGTGTATGTTTTTTTAACTTTACTAT
  AAAGCCATGCAAATGACAAAAATCTATATTACTTTCTCAAAATGGACCCCAAAGAAACTT
  TGATTTACTGTTCTTAACTGCCTAATCTTAATTACAGGAACTGTGCATCAGCTATTTATG
  ATTCTATAAGCTATTTCAGCAGAATGAGATATTAAACCCAATGCTTTGATTGTTCTAGAA
  AGTATAGTAATTTGTTTTCTAAGGTGGTTCAAGCATCTACTCTTTTTATCATTTACTTCA
  AAATGACATTGCTAAAGACTGCATTATTTTACTACTGTAATTTCTCCACGACATAGCATT
  ATGTACATAGATGAGTGTAACATTTATATCTCACATAGAGACATGCTTATATGGTTTTAT
  TTAAAATGAAATGCCAGTCCATTACACTGAATAAATAGAACTCAACTATTGCTTTTCAGG
  GAAATCATGGATAGGGTTGAAGAAGGTTACTATTAATTGTTTAAAAACAGCTTAGGGATT
  AATGTCCTCCATTTATAATGAAGATTAAAATGAAGGCTTTAATCAGCATTGTAAAGGAAA
  TTGAATGGCTTTCTGATATGCTGTTTTTTAGCCTAGGAGTTAGAAATCCTAACTTCTTTA
  TCCTCTTCTCCCAGAGGCTTTTTTTTTCTTGTGTATTAAATTAACATTTTTAAAAAGCAG
  ATATTTTGTCAAGGGGCTTTGCATTCAAACTGCTTTTCCAGGGCTATACTCAGAAGAAAG
  ATAAAAGTGTGATCTAAGAAAAAGTGATGGTTTTAGGAAAGTGAAAATATTTTTGTTTTT
  GTATTTGAAGAAGAATGATGCATTTTGACAAGAAATCATATATGTATGGATATATTTTAA
  TAAGTATTTGAGTACAGACTTTGAGGTTTCATCAATATAAATAAAAGAGCAGAAAAATAA
  AAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_199328.1 unedited
  TCGATTGTATACGACTCCTATAGGGCGGCAGGGAATTCGGCCATTACGGCCGGGACAGAG
  AACCCTGCTTCAAAGCAGAAGTAGCAGTTCCGGAGTCCAGCTGGCTAAAACTCATCCCAG
  AGGATAATGGCAACCCATGCCTTAGAAATCGCTGGGCTGTTTCTTGGTGGTGTTGGAATG
  GTGGGCACAGTGGCTGTCACTGTCATGCCTCAGTGGAGAGTGTCGGCCTTCATTGAAAAC
  AACATCGTGGTTTTTGAAAACTTCTGGGAAGGACTGTGGATGAATTGCGTGAGGCAGGCT
  AACATCAGGATGCAGTGCAAAATCTATGATTCCCTGCTGGCTCTTTCTCCGGACCTACAG
  GCAGCCAGAGGACTGATGTGTGCTGCTTCCGTGATGTCCTTCTTGGCTTTCATGATGGCC
  ATCCTTGGCATGAAATGCACCAGGTGCACGGGGGACAATGAGAAGGTGAAGGCTCACATT
  CTGCTGACGGCTGGAATCATCTTCATCATCACGGGCATGGTGGTGCTCATCCCTGTGAGC
  TGGGTTGCCAATGCCATCATCAGAGATTTCTATAACTCAATAGTGAATGTTGCCCAAAAA
  CGTGAGCTTGGAGAAGCTCTCTACTTAGATGGACCACGGCACTGGTGCTGATTGTTGGAG
  GAGCTCTGTTCTGCTGCGTTTTTTGTTGCAACGAAAAGAGCAGTAGCTACAGATACTCGA
  TACCTTCCCATCGCACAACCCAAAAAAAGTTATCACACCGGAAAGAAGTCACCGAGCGTC
  TACTCCAGAGTCAGTATGTGTAGTTGTGTATGTTTTTTTTAACTTTACTATAAGCCATGC
  AATGACAAAATCTATATTACTTTCTCAAATGAACCCAAGACTTGGATTACTGTTCTTACT
  GGCTATCTATACGAACTGTGCATCAGCTTTTATGATTCTTAAGCTATTCGCAAATGAAAA
  TTAACCAAGGGCTTGAT
• Restriction Sites: Please inquire
• ACCN: NM_199328
• ORF Size: 678 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_199328.1, NP_955360.1
• RefSeq Size: 1989
• RefSeq ORF: 678
• Locus ID: 9073
• Protein Families: Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction
• Gene Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma. [provided by RefSeq, May 2010]