PABP2 (PABPN1) (NM_004643) Human Untagged Clone

CAT#: SC321087

PABPN1 (untagged)-Human poly(A) binding protein, nuclear 1 (PABPN1)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PABPN1
• Synonyms: OPMD; PAB2; PABII; PABP-2; PABP2
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_004643.1 GGGGGGCGATGGCGGCGGCGGCGGCGGCGGCAGCAGCAGCGGGGGCTGCGGGCGGTCGGG
  GCTCCGGGCCGGGGCGGCGGCGCCATCTTGTGCCCGGGGCCGGTGGGGAGGCCGGGGAGG
  GGGCCCCGGGGGGCGCAGGGGACTACGGGAACGGCCTGGAGTCTGAGGAACTGGAGCCTG
  AGGAGCTGCTGCTGGAGCCCGAGCCGGAGCCCGAGCCCGAAGAGGAGCCGCCCCGGCCCC
  GCGCCCCCCCGGGAGCTCCGGGCCCTGGGCCTGGTTCGGGAGCCCCCGGCAGCCAAGAGG
  AGGAGGAGGAGCCGGGACTGGTCGAGGGTGACCCGGGGGACGGCGCCATTGAGGACCCGG
  AGCTGGAAGCTATCAAAGCTCGAGTCAGGGAGATGGAGGAAGAAGCTGAGAAGCTAAAGG
  AGCTACAGAACGAGGTAGAGAAGCAGATGAATATGAGTCCACCTCCAGGCAATGCTGGCC
  CGGTGATCATGTCCATTGAGGAGAAGATGGAGGCTGATGCCCGTTCCATCTATGTTGGCA
  ATGTGGACTATGGTGCAACAGCAGAAGAGCTGGAAGCTCACTTTCATGGCTGTGGTTCAG
  TCAACCGTGTTACCATACTGTGTGACAAATTTAGTGGCCATCCCAAAGGGTTTGCGTATA
  TAGAGTTCTCAGACAAAGAGTCAGTGAGGACTTCCTTGGCCTTAGATGAGTCCCTATTTA
  GAGGAAGGCAAATCAAGGTGATCCCAAAACGAACCAACAGACCAGGCATCAGCACAACAG
  ACCGGGGTTTTCCACGAGCCCGCTACCGCGCCCGGACCACCAACTACAACAGCTCCCGCT
  CTCGATTCTACAGTGGTTTTAACAGCAGGCCCCGGGGTCGCGTCTACAGGGGCCGGGCTA
  GAGCGACATCATGGTATTCCCCTTACTAAAAAAAGTGTGTATTAGGAGGAGAGAGAGGAA
  AAAAAGAGGAAAGAAGTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_004643.1 unedited
  CCCCCAATTGTATACGACTCCTATAGGGCGGAAGAAAAAACGGCCTTCCGGCCGGGGGGC
  GATGGCGGCGGAGGCGGCGGCGGCAGCAGCAGCGGGGGCTGCGGGCGGTCGGGGCTCCGG
  GCCGGGGCGGCGGTGCCATCTTGTGCCCGGGGCCGGTGGGGAGGCCGGGGAGGGGGCCCT
  GGGGGGCGCAGGGGACTACGGGAACGGCCTGGAGTCTGAGGAACTGGAGCCTGAGGAGCT
  GCTGCTGGAGCCCGAGCCGGAGCCCGAGCCCGAAGAGGAGCCGCCCCGGTCCCGCGCCCC
  CCCGGGAGCTCCGGGCCCTGGGCCTGGTTTGGGAGCCCCTGGCACCCAAGAGGAGGATGA
  GGAGCCGGGACTGGTCGATGGTGACCCGGCGGACGGCCCTATTGAGGACCCTGAGCTGGA
  AGCTATCAAAGCTCGAGTCAGGGATATGGAGGAAGAAGCTGAGAATCTAAAGGACCTACC
  CATCTTCTCTGAGAATCTGTGAATATGACTCCATCTCCAGCTTTTTGCTGTCTCCGGTGA
  TCATGTTTTTCTGTGTATATTTTGGAGAGCTGATGCCCGTTCTGTCTTTGTTTTCAATGT
  GCACTATGGTGCAAAAGTTTCAAATAGCTGTTAGCT
• Restriction Sites: Please inquire
• ACCN: NM_004643
• ORF Size: 921 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_004643.1, NP_004634.1
• RefSeq Size: 3107
• RefSeq ORF: 921
• Locus ID: 8106
• Domains: RRM
• Protein Families: Druggable Genome
• Gene Summary: This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene. [provided by RefSeq, Dec 2010]