POT1 (NM_001042594) Human Untagged Clone

CAT#: SC321304

POT1 (untagged)-Human protection of telomeres 1 homolog (S. pombe) (POT1), transcript variant 4

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: POT1
• Synonyms: CMM10; GLM9; HPOT1
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_001042594.1 CTCAAATCAACTGTTTATGTTTATGTCAAATCTTTAAGAGATTTTTCTACAGAATCAATG
  TCTTTGGTTCCAGCAACAAATTATATATATACACCCCTGAATCAACTTAAGGGTGGTACA
  ATTGTCAATGTCTATGGTGTTGTGAAGTTCTTTAAGCCCCCATATCTAAGCAAAGGAACT
  GATTATTGCTCAGTTGTAACTATTGTGGACCAGACAAATGTAAAACTAACTTGCCTGCTC
  TTTAGTGGAAACTATGAAGCCCTTCCAATAATTTATAAAAATGGAGATATTGTTCGCTTT
  CACAGGCTGAAGATTCAAGTATATAAAAAGGAGACTCAGGGTATCACCAGCTCTGGCTTT
  GCATCTTTGACGTTTGAGGGAACTTTGGGAGCCCCTATCATACCTCGCACTTCAAGCAAG
  TATTTTAACTTCACTACTGAGGACCACAAAATGGTAGAAGCCTTACGTGTTTGGGCATCT
  ACTCATATGTCACCGTCTTGGACATTACTAAAATTGTGTGATGTTCAGCCAATGCAGTAT
  TTTGACCTGACTTGTCAGCTCTTGGGCAAAGCAGAAGTGGACGGAGCATCATTTCTTCTA
  AAGGTATGGGATGGCACCAGGACACCATTTCCATCTTGGAGAGTCTTAATACAAGACCTT
  GTTCTTGAAGGTGATTTAAGTCACATCCATCGGCTACAAAATCTGACAATAGACATTTTA
  GTCTACGATAACCATGTTCATGTGGCAAGATCTCTGAAGGTTGGAAGCTTTCTTAGAATC
  TATAGCCTTCATACCAAACTTCAATCAATGAATTCAGAGAATCAGACAATGTTAAGTTTA
  GAGTTTCATCTTCATGGAGGTACCAGTTACGGTCGGGGAATCAGGGTCTTGCCAGAAAGT
  AACTCTGATGTGGATCAACTGAAAAAGGATTTAGAATCTGCAAATTTGACAGCCAATCAG
  CATTCAGATGTTATCTGTCAATCAGAACCTGACGACAGCTTTCCAAGCTCTGGATCAGTA
  TCATTATACGAGGTAGAAAGATGTCAACAGCTATCTGCTACAATACTTACAGATCATCAG
  TATTTGGAGAGGACACCACTATGTGCCATTTTGAAACAAAAAGCTCCTCAACAATACCGC
  ATCCGAGCAAAATTGAGGTCATATAAGCCCAGAAGACTATTTCAGTCTGTTAAACTTCAT
  TGCCCTAAATGTCATTTGCTGCAAGAAGTTCCACATGAGGGCGATTTGGATATAATTTTT
  CAGGATGGTGCAACTAAAACCCCAGATGTCAAGCTACAAAATACATCATTATATGATTCA
  AAAATCTGGACCACTAAAAATCAAAAAGGACGAAAAGTAGCAGTTCATTTTGTGAAAAAT
  AATGGTATTCTCCCGCTTTCAAATGAATGTCTACTTTTGATAGAAGGAGGTACACTCAGT
  GAAATTTGCAAACTCTCGAACAAGTTTAATAGTGTAATTCCTGTGAGATCTGGCCACGAA
  GACCTGGAACTTTTGGACCTTTCAGCACCATTTCTTATACAAGGAACAATACATCACTAT
  GGATGTAAACAGTGTTCTAGTTTGAGATCCATACAAAATCTAAATTCCCTGGTTGATAAA
  ACATCGTGGATTCCTTCTTCTGTGGCAGAAGCACTGGGTATTGTACCCCTCCAATATGTG
  TTTGTTATGACCTTTACACTTGATGATGGAACAGGAGTACTAGAAGCCTATCTCATGGAT
  TCTGACAAATTCTTCCAGATTCCAGCATCAGAAGTTCTGATGGATGATGACCTTCAGAAA
  AGTGTGGATATGATCATGGATATGTTTTGTCCTCCAGGAATAAAAATTGATGCATATCCG
  TGGTTGGAATGCTTCATCAAGTCATACAATGTCACAAATGGAACAGATAATCAAATTTGC
  TATCAGATTTTTGACACCACAGTTGCAGAAGATGTAATCTAATATTGCCATCCAATTTAG
  CATACATAAAATGTTGCCACTCAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_001042594.1 unedited
  CACCTTGTATACGACTCCTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAG
  GAGATCTGCCGCCGCGATCGCGGCGCGCCAGATCTCAAGCTTAACTAGTTAGCGGACCGA
  CGCGTTAAGCGGCCGCGAATTCAGATCCACAAGTTTGTACAAAAAAGCAGGCTTGTAAAA
  CGACGGCCAGTAACTATAACGGTCCTAAGGTAGCGAGGCCTGGGTGGCGAATTCGGCACG
  AGGCTCAAATCAACTGTTTATGTTTATGTCAAATCTTTAAGAGATTTTTCTACAGAATCA
  ATGTCTTTGGTTCCAGCAACAAATTATATATATACACCCCTGAATCAACTTAAGGGTGGT
  ACAATTGTCAATGTCTATGGTGTTGTGAAGTTCTTTAAGCCCCCATATCTAAGCAAAGGA
  ACTGATTATTGCTCAGTTGTAACTATTGTGGACCAGACAAATGTAAAACTAACTTGCCTG
  CTCTTTAGTGGAAACTATGAAGCCCTTCCAATAATTTATAAAAATGGAGATATTGTTCGC
  TTTCACAGGCTGAAGATTCAAGTATATAAAAAGGAGACTCAGGGTATCACCAGCTCTGGC
  TTTGCATCTTTGACGTTTGAGGGAACTTTGGGAGCCCCTATCATACCTCGCACTTCAAGC
  AAGTATTTTAACTTCACTACTGAGACCACAAAATGGTAGAAGCCCTTACGTGTTTGGGCA
  TCTACTCATATGTCACCGTCTTGACATTACTAAAATGTGGTGATGTTCAGGCATGCAGTA
  TTTTGACCTGACTTGTCAGCTTTTGGCAAGCAGATGGAACGGAGCATCCATTTCTTCTAA
  GTTATTGGGATGGCACCAGGACACCATCAATCTTGGAGAGTTCTTATAATACAAGAACCT
  TGTTCTTGAAGGTGATTTAAGTTACAATTTCC
• Restriction Sites: Please inquire
• ACCN: NM_001042594
• ORF Size: 1512 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001042594.1, NP_001036059.1
• RefSeq Size: 3964
• RefSeq ORF: 1512
• Locus ID: 25913
• Gene Summary: This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon, compared to variant 1. The encoded isoform (5, also known as POT1-55) has a shorter N-terminus, compared to isoform 1. There are currently no publicly available full-length transcripts representing this variant, but it is supported by data in PMIDs 12391173 and 15973431.