EIF4EL3 (EIF4E2) (NM_004846) Human Untagged Clone

CAT#: SC321530

EIF4E2 (untagged)-Human eukaryotic translation initiation factor 4E family member 2 (EIF4E2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: EIF4E2
• Synonyms: 4E-LP; 4EHP; EIF4EL3; h4EHP; IF4e
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_004846.2 GGGACCCGGTGGAGCGGAAGTCACTCCCTGAGGCAGTGGCGACAGCGGCGGCGAGAGGAT
  GAACAACAAGTTCGACGCTTTGAAAGATGATGACAGTGGGGACCATGATCAGAATGAAGA
  AAACAGCACACAGAAAGATGGTGAGAAGGAAAAAACGGAACGAGACAAGAATCAGAGCAG
  TAGCAAGAGAAAGGCTGTTGTCCCTGGACCGGCAGAGCATCCCCTGCAGTACAACTACAC
  TTTTTGGTACTCCAGGAGAACCCCCGGCCGTCCCACGAGCTCACAGAGCTATGAACAGAA
  TATCAAACAGATTGGCACCTTTGCCTCTGTGGAGCAGTTCTGGAGGTTTTATAGCCACAT
  GGTACGTCCTGGGGACCTGACAGGCCACAGTGACTTCCATCTCTTCAAAGAAGGAATTAA
  ACCCATGTGGGAGGATGATGCAAATAAAAATGGTGGCAAGTGGATTATTCGGCTGCGGAA
  GGGCTTGGCCTCCCGTTGCTGGGAGAATCTCATTTTGGCCATGCTGGGGGAACAGTTCAT
  GGTTGGGGAGGAGATCTGTGGGGCTGTGGTGTCTGTCCGCTTTCAGGAAGACATTATTTC
  AATATGGAATAAGACTGCCAGTGACCAAGCAACCACAGCCCGAATCCGGGACACACTTCG
  GCGAGTGCTTAACCTACCTCCCAACACCATTATGGAATACAAAACTCACACCGACAGCAT
  CAAAATGCCAGGCAGGCTGGGCCCCCAAAGGCTCCTTTTTCAAAACCTCTGGAAGCCGCG
  GTTGAATGTGCCATGACCCTCTCCCTCTCTGGATGGCACCATCATTGAAGCTGGCGTCAT
  CGGAGTCTCTTGTTCTGTTGGCGTGCTACCTGGAAGATCCTTCTGTCCTGGACAAGAGGA
  ATTGGAAGAGCATTTTATGTTTTAAGAACAGGCTGACACGCAGCAGCTACAACAACAGCT
  GAGATCACTTAATAAATGGTGCTAAACTAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_004846.2 unedited
  GGCATTTGTATACGACTCCTATAGGGCGGCCGGGAATTCGGCACGAGGGGGACCCGGTGG
  AGCGGAAGTCACTCCCTGAGGCAGTGGCGACAGCGGCGGCGAGAGGATGAACAACAAGTT
  CGACGCTTTGAAAGATGATGACAGTGGGGACCATGATCAGAATGAAGAAAACAGCACACA
  GAAAGATGGTGAGAAGGAAAAAACGGAACGAGACAAGAATCAGAGCAGTAGCAAGAGAAA
  GGCTGTTGTCCCTGGACCGGCAGAGCATCCCCTGCAGTACAACTACACTTTTTGGTACTC
  CAGGAGAACCCCCGGCCGTCCCACGAGCTCACAGAGCTATGAACAGAATATCAAACAGAT
  TGGCACCTTTGCCTCTGTGGAGCAGTTCTGGAGGTTTTATAGCCACATGGTACGTCCTGG
  GGACCTGACAGGCCACAGTGACTTCCATCTCTTCAAAGAAGGAATTAAACCCATGTGGGA
  GGATGATGCAAATAAAAATGGTGGCAAGTGGATTATTCGGCTGCGGAAGGGCTTGGCCTC
  CCGTTGCTGGGAGAATCTCATTTTGGCCATGCTGGGGGAACAGTTCATGGTTGGGGAGGA
  GATCTGTGGGGCTGTGGTGTCTGTCCGCTTTCAGAAGACATTATTTCAATATGGAATAAG
  ACTGCCAGTGACCAAGCAACCACAGCCCGAATCCGGGACACACTTCGCGAGTGCTTAACC
  TACCTCCCACACCATTATGGATACAACTCACACCGACAGCATCAAATGCCAGGCAGCTGG
  GCCCCAAGCTCTTTTCAAACCTCTGAGCGCGTGATGTGCATGACCTCTCCCTCTCTGATG
  CACATCATGAGCTGCGTCATCGGAGTCTCTTTGTTCTGTTGCGTGCTACTGGAGATC
• Restriction Sites: Please inquire
• ACCN: NM_004846
• ORF Size: 738 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_004846.2, NP_004837.1
• RefSeq Size: 1014
• RefSeq ORF: 738
• Locus ID: 9470
• Domains: IF4E
• Protein Families: Transcription Factors
• Protein Pathways: Insulin signaling pathway, mTOR signaling pathway
• Gene Summary: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation (PubMed:9582349, PubMed:17368478, PubMed:25624349). Acts as a repressor of translation initiation (PubMed:22751931). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap. [UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (1) encodes the longest isoform (A).