DARPP32 (PPP1R1B) (NM_181505) Human Untagged Clone

CAT#: SC321536

PPP1R1B (untagged)-Human protein phosphatase 1, regulatory (inhibitor) subunit 1B (PPP1R1B), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PPP1R1B
• Synonyms: DARPP-32; DARPP32
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_181505.1 GTGAAGAGTTCTGCAGCCTTACAGAGACTGGAAAAGAAGCCCAAACCAAGGCCCCCAGAG
  AGGTCCCCCAGGCCCCTTTGGGTCCCTGAGCCTCAGCTGGAGGTGGGGGGTGCCTGCAGT
  GCGCTGGCTCAGTCTCCTTCTGAAAAGCTGGATCCAGCTTGTTTGAAGCCCTTGAGCTGA
  TCTTAGATCCGGCGCAGGAGACCAACGCCTGCCATGCTGTTCCGGCTCTCAGAGCACTCC
  TCACCAGAGGAGGAAGCCTCCCCCCACCAGAGAGCCTCAGGAGAGGGGCACCATCTCAAG
  TCGAAGAGACCCAACCCCTGTGCCTACACACCACCTTCGCTGAAAGCTGTGCAGCGCATT
  GCTGAGTCTCACCTGCAGTCTATCAGCAATTTGAATGAGAACCAGGCCTCAGAGGAGGAG
  GATGAGCTGGGGGAGCTTCGGGAGCTGGGTTATCCAAGAGAGGAAGATGAGGAGGAAGAG
  GAGGATGATGAAGAAGAGGAAGAAGAAGAGGACAGCCAGGCTGAAGTCCTGAAGGTCATC
  AGGCAGTCTGCTGGGCAAAAGACAACCTGTGGCCAGGGTCTGGAAGGGCCCTGGGAGCGC
  CCACCCCCTCTGGATGAGTCCGAGAGAGATGGAGGCTCTGAGGACCAAGTGGAAGACCCA
  GCACTAAGTGAGCCTGGGGAGGAACCTCAGCGCCCTTCCCCCTCTGAGCCTGGCACATAG
  GCACCCAGCCTGCATCTCCCAGGAGGAAGTGGAGGGGACATCGCTGTTCCCCAGAAACCC
  ACTCTATCCTCACCCTGTTTTGTGCTCTTCCCCTCGCCTGCTAGGGCTGCGGCTTCTGAC
  TTCTAGAAGACTAAGGCTGGTCTGTGTTTGCTTGTTTGCCCACCTTTGGCTGATACCCAG
  AGAACCTGGGCACTTGCTGCCTGATGCCCACCCCTGCCAGTCATTCCTCCATTCACCCAG
  CGGGAGGTGGGATGTGAGACAGCCCACATTGGAAAATCCAGAAAACCGGGAACAGGGATT
  TGCCCTTCACAATTCTACTCCCCAGATCCTCTCCCCTGGACACAGGAGACCCACAGGGCA
  GGACCCTAAGATCTGGGGAAAGGAGGTCCTGAGAACCTTGAGGTACCCTTAGATCCTTTT
  CTACCCACTTTCCTATGGAGGATTCCAAGTCACCACTTCTCTCACCGGCTTCTACCAGGG
  TCCAGGACTAAGGCGTTTTTCTCCATAGCCTCAACATTTTGGGAATCTTCCCTTAATCAC
  CCTTGCTCCTCCTGGGTGCCTGGAAGATGGACTGGCAGAGACCTCTTTGTTGCGTTTTGT
  GCTTTGATGCCAGGAATGCCGCCTAGTTTATGTCCCCGGTGGGGCACACAGCGGGGGGCG
  CCAGGTTTTCCTTGTCCCCCAGCTGCTCTGCCCCTTTCCCCTTCTTCCCTGACTCCAGGC
  CTGAACCCCTCCCGTGCTGTAATAAATCTTTGTAAATAACAAAAAAAAAAAAAAAAAAAA
  AAAAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_181505.1 unedited
  GACGTTTGTATACGACTCCTATAGGGCGGCCGGGAATTCGGCACGAGGGTGAAGAGTTCT
  GCAGCCTTACAGAGACTGGAAAAGAAGCCCAAACCAAGGCCCCCAGAGAGGTCCCCCAGG
  CCCCTTTGGGTCCCTGAGCCTCAGCTGGAGGTGGGGGGTGCCTGCAGTGCGCTGGCTCAG
  TCTCCTTCTGAAAAGCTGGATCCAGCTTGTTTGAAGCCCTTGAGCTGATCTTAGATCCGG
  CGCAGGAGACCAACGCCTGCCATGCTGTTCCGGCTCTCAGAGCACTCCTCACCAGAGGAG
  GAAGCCTCCCCCCACCAGAGAGCCTCAGGAGAGGGGCACCATCTCAAGTCGAAGAGACCC
  AACCCCTGTGCCTACACACCACCTTCGCTGAAAGCTGTGCAGCGCATTGCTGAGTCTCAC
  CTGCAGTCTATCAGCAATTTGAATGAGAACCAGGCCTCAGAGGAGGAGGATGAGCTGGGG
  GAGCTTCGGGAGCTGGGTTATCCAAGAGAGGAAGATGAGGAGGAAGAGGAGGATGATGAA
  GAAGAGGAAGAAGAAGAGGACAGCCAGGCTGAAGTCCTGAAGGTCATCAGGCAGTCTGCT
  GGGCAAAAGACAACCTGTGGCCAGGGTCTGGAAGGGCCCTGGGAGCGCCCACCCCCTCTG
  GATGAGTCCGAGAGAGATGGAGGCTCTGAGACCAAGTGGAAGACCCAGCACTAAGTGAGC
  CTGGGGAGGAACCTCAGCGCCCTTCCCCCTCTGAGCCTGGCACATAGCCCCCAGCCTGCA
  TCTCCCAGGAGGAAGTGGAGGGGACATCGCTGTTCCCCAGACCCACTCTATCCTCACCCT
  GTTTTGTGCTCTTCCCTCGCCTGCTAGGCTGCGGCTCTGACTTCTAGAGACTAGCTGGTC
  TGTGTTGCTTGTTGCCCACCTTTGGCTGAACCCAGAGAACCTGGCACTTGCTG
• Restriction Sites: Please inquire
• ACCN: NM_181505
• ORF Size: 507 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_181505.1, NP_852606.1
• RefSeq Size: 1529
• RefSeq ORF: 507
• Locus ID: 84152
• Protein Families: Druggable Genome
• Gene Summary: This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
  Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. Variants 2 and 3 encode isoform 2.