HYAL2 (NM_033158) Human Untagged Clone

CAT#: SC321575

HYAL2 (untagged)-Human hyaluronoglucosaminidase 2 (HYAL2), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: HYAL2
• Synonyms: LUCA2
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_033158.2 AGGCGCTGAGCCGGGCCGCGCCTGGGCGAACGGCCGGAGCGGGCTGGGCTGGGCCCGGGA
  TGGCGGTGGCCCTGGCGCCGGTCCCGGTGGCGCCCCGCGCGAGTTCCTGAGCTGGTGCCA
  GGCAGGTGACACCTCCTGCAGCCCCCAGCATGCGGGCAGGCCCAGGCCCCACCGTTACAT
  TGGCCCTGGTGCTGGCGGTGGCATGGGCCATGGAGCTCAAGCCCACAGCACCACCCATCT
  TCACTGGCCGGCCCTTTGTGGTAGCGTGGGACGTGCCCACACAGGACTGTGGCCCACGCC
  TCAAGGTGCCACTGGACCTGAATGCCTTTGATGTGCAGGCCTCACCTAATGAGGGTTTTG
  TGAACCAGAATATTACCATCTTCTACCGCGACCGTCTAGGCCTGTATCCACGCTTCGATT
  CTGCCGGAAGGTCTGTGCATGGTGGTGTGCCACAGAATGTCAGCCTTTGGGCACACCGGA
  AGATGCTGCAGAAACGTGTGGAGCACTACATTCGGACACAGGAGTCTGCGGGGCTGGCGG
  TCATCGACTGGGAGGACTGGCGACCTGTGTGGGTGCGCAACTGGCAGGACAAAGATGTGT
  ATCGCCGGTTATCACGCCAGCTAGTGGCCAGTCGTCACCCTGACTGGCCTCCAGACCGCA
  TAGTCAAACAGGCACAATATGAGTTTGAGTTCGCAGCACAGCAGTTCATGCTGGAGACAC
  TGCGTTATGTCAAGGCAGTGCGGCCCCGGCACCTCTGGGGCTTCTACCTCTTTCCTGACT
  GCTACAATCATGATTATGTGCAGAACTGGGAGAGCTACACAGGCCGCTGCCCTGATGTTG
  AGGTGGCCCGCAATGACCAGCTGGCCTGGCTGTGGGCTGAGAGCACGGCCCTCTTCCCGT
  CTGTCTACCTGGACGAGACACTTGCTTCCTCCCGCCATGGCCGCAACTTTGTGAGCTTCC
  GTGTTCAGGAGGCCCTTCGTGTGGCTCGCACCCACCATGCCAACCATGCACTCCCAGTCT
  ACGTCTTCACACGACCCACCTACAGCCGCAGGCTCACGGGGCTTAGTGAGATGGACCTCA
  TCTCTACCATTGGCGAGAGTGCGGCCCTGGGCGCAGCTGGTGTCATCCTCTGGGGTGACG
  CGGGGTACACCACAAGCACGGAGACCTGCCAGTACCTCAAAGATTACCTGACACGGCTGC
  TGGTCCCCTACGTGGTCAATGTGTCCTGGGCCACCCAATATTGCAGCCGGGCCCAGTGCC
  ATGGCCATGGGCGCTGTGTGCGCCGCAACCCCAGTGCCAGTACCTTCCTGCATCTCAGCA
  CCAACAGTTTCCGCCTAGTGCCTGGCCATGCACCTGGTGAACCCCAGCTGCGACCTGTGG
  GGGAGCTCAGTTGGGCCGACATTGACCACCTGCAGACACACTTCCGCTGCCAGTGCTACT
  TGGGCTGGAGTGGTGAGCAATGCCAGTGGGACCATAGGCAGGCAGCTGGAGGTGCCAGCG
  AGGCCTGGGCTGGGTCCCACCTCACCAGTCTGCTGGCTCTGGCAGCCCTGGCCTTTACCT
  GGACCTTGTAGGGGTCTCCTGCCTAGCTGCCTAGCAAGCTGGCCTCTACCACAAGGGCTC
  TCTTAGGCATGTAGGACCCTGCAGGGGGTGGACAAACTGGAGTCTGGAGTGGGCAGAGCC
  CCCAGGAAGCCCAGGAGGGCATCCATACCAGCTCGCACCCCCCTGTTCTAAGGGGGAGGG
  GAAGTCCCTGGGAGGCCCCTTCTCTCCCTGCCAGAGGGGAAGGAGGGTACAGCTGGGCTG
  GGGAGGACCTGACCCTACTCCCTTGCCCTAGATAGTTTATTATTATTATTATTTTGGGGT
  CTCTTTTGTAAATTAAACATAAAACAATTGCAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_033158.2 unedited
  GACCTTTGTATACGACTCCTATAGGGCGGCCGGGAATTCGGCACGAGGAGGCGCTGAGCC
  GGGCCGCGCCTGGGCGAACGGCCGGAGCGGGCTGGGCTGGGCCCGGGATGGCGGTGGCCC
  TGGCGCCGGTCCCGGTGGCGCCCCGCGCGAGTTCCTGAGCTGGTGCCAGGCAGGTGACAC
  CTCCTGCAGCCCCCAGCATGCGGGCAGGCCCAGGCCCCACCGTTACATTGGCCCTGGTGC
  TGGCGGTGGCATGGGCCATGGAGCTCAAGCCCACAGCACCACCCATCTTCACTGGCCGGC
  CCTTTGTGGTAGCGTGGGACGTGCTCACACAGGACTGTGGCCCACGCCTCAAGGTGCCAC
  TGGACCTGAATGCCTTTGATGTGCAGGCCTCACCTAATGAGGGTTTTGTGAACCAGAATA
  TTACCATCTTCTACCGCGACCGTCTAGGCCTGTATCCACGCTTCGATTCTGCCGGAAGGT
  CTGTGCATGGTGGTGTGCCACAGAATGTCAGCCTTTGGGCACACCGGAAGATGCTGCAGA
  AACGTGTGGAGCACTACATTCGGACACAGGAGTCTGCGGGGCTGGCGGTCATCGACTGGG
  AGGACTGGCGACCTGTGTGGGTGCGCAACTGGCAGACAAAGATGTGTATCGCCGGTTATC
  ACGCCAGCTAGTGGCCAGTCGTCACCCTGACTGGCCCTCCAGACCGCATAGTCAAACAGG
  CACAATATGAGTTTGAGTTCCGCAGCACAGCAGTTCATGCTGGAGACCACTGCGTTATTG
  TCAAGGCAGTGCGGCCCCGGCACCTCTGGGGCTTCTACCTCTTTCCTGACTGCTAACAAT
  CATGATTATTGTGCAGACTGGGAGAGCCTACACCAGCCGCTGCCTGATGTTGAGTGCCGC
  ATGACCAGCTGACTGGCTGTGGGCTGAAAAGACACTGACCTCTACCGGTTCTGTCTAACT
  TGGACCGAGAACCTTGCTTTCCTTCCCGGCCCATTGGCCGCGCACACGGTG
• Restriction Sites: Please inquire
• ACCN: NM_033158
• ORF Size: 1422 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_033158.2, NP_149348.2
• RefSeq Size: 1909
• RefSeq ORF: 1422
• Locus ID: 8692
• Domains: Glyco_hydro_56
• Protein Families: Druggable Genome
• Protein Pathways: Glycosaminoglycan degradation, Metabolic pathways
• Gene Summary: This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR. [provided by RefSeq, Mar 2010]
  Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.