PIAS2 (NM_173206) Human Untagged Clone

CAT#: SC321603

PIAS2 (untagged)-Human protein inhibitor of activated STAT, 2 (PIAS2), transcript variant alpha

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PIAS2
• Synonyms: ARIP3; DIP; MIZ1; PIASX; SIZ2; ZMIZ4
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_173206.2 GACGGGCCCGGCTGTAGCGGCGGCGGCCGCGGCGTCTTAAGCGGCGCCCAGTGCAGGATG
  GTGCTGGAGGCGGCGGCGGCCGTGGTGGCGGCAGCGTCGTTGGCGGCAGCGGGAGTGGGT
  GCGGCGGCAGCGGCGGCGGCGCCCGCGGGTGGTATAAAATGGCGGATTTCGAAGAGTTGA
  GGAATATGGTTTCTAGTTTTAGGGTTTCTGAACTACAAGTATTACTAGGCTTTGCTGGAC
  GGAATAAAAGTGGACGCAAGCATGACCTCCTGATGAGGGCGCTGCATTTATTGAAGAGCG
  GCTGCAGCCCTGCGGTTCAGATTAAAATCCGAGAATTGTATAGACGCCGATATCCACGAA
  CTCTTGAAGGACTTTCTGATTTATCCACAATCAAATCATCGGTTTTCAGTTTGGATGGTG
  GCTCATCACCTGTAGAACCTGACTTGGCCGTGGCTGGAATCCACTCGTTGCCTTCCACTT
  CAGTTACACCTCACTCACCATCCTCTCCTGTTGGTTCTGTGCTGCTTCAAGATACTAAGC
  CCACATTTGAGATGCAGCAGCCATCTCCCCCAATTCCTCCTGTCCATCCTGATGTGCAGT
  TAAAAAATCTGCCCTTTTATGATGTCCTTGATGTTCTCATCAAGCCCACGAGTTTAGTTC
  AAAGCAGTATTCAGCGATTTCAAGAGAAGTTTTTTATTTTTGCTTTGACACCTCAACAAG
  TTAGAGAGATATGCATATCCAGGGATTTTTTGCCAGGTGGTAGGAGAGATTATACAGTCC
  AAGTTCAGTTGAGACTTTGCCTGGCAGAGACAAGTTGCCCTCAAGAAGATAACTATCCAA
  ATAGTCTATGTATAAAAGTAAATGGGAAGCTATTTCCTTTGCCTGGCTATGCACCACCGC
  CTAAAAATGGGATTGAACAGAAGCGCCCTGGACGCCCCTTGAATATTACATCTTTAGTTA
  GGTTATCTTCAGCTGTGCCAAACCAAATTTCCATTTCTTGGGCATCAGAAATTGGGAAGA
  ATTACTCTATGTCTGTATATCTTGTACGGCAGCTTACATCAGCCATGTTATTACAGAGAT
  TAAAAATGAAAGGTATTAGAAACCCTGATCATTCCAGAGCACTAATTAAAGAAAAACTTA
  CTGCAGATCCTGATAGTGAAATTGCTACAACTAGCCTTCGGGTATCCTTGATGTGCCCTT
  TAGGAAAAATGAGGCTGACAATCCCATGCCGTGCAGTGACTTGTACACATCTGCAGTGTT
  TTGATGCTGCCCTCTATCTACAAATGAATGAGAAAAAGCCCACCTGGATTTGTCCTGTGT
  GTGACAAAAAAGCTGCCTATGAAAGTCTAATATTAGATGGGCTTTTTATGGAAATTCTCA
  ATGACTGTTCTGATGTAGATGAGATCAAATTCCAAGAAGATGGTTCTTGGTGTCCAATGA
  GACCGAAGAAAGAAGCTATGAAAGTATCCAGCCAACCGTGTACAAAAATAGAAAGTTCAA
  GCGTCCTCAGTAAGCCTTGTTCAGTGACTGTAGCCAGTGAGGCAAGCAAGAAGAAAGTAG
  ATGTTATTGATCTTACAATAGAAAGCTCTTCTGACGAAGAGGAAGACCCTCCTGCCAAAA
  GGAAATGCATCTTTATGTCAGAAACACAAAGCAGCCCAACCAAAGGGGTTCTCATGTATC
  AGCCATCTTCTGTAAGGGTGCCCAGTGTGACTTCGGTTGATCCTGCTGCTATTCCGCCTT
  CATTAACAGACTACTCAGTACCATTCCACCATACGCCAATATCAAGCATGTCATCAGATT
  TGCCAGGAGAACAAAGAAGAAATGATATTAATAATGAACTGAAGCTTGGAACATCTTCTG
  ATACTGTGCAACAGTGAATACAAAATAAAACAAATAATTCGAAAAAAAAAAAAAAAAAAA
  AAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_173206.2 unedited
  GGCGTTTGTATACGACTCCTATAGGGCGGCCGGGAATTCGGCCATTACGGCCGGGGGACG
  GGCCCGGCTGTAGCGGCGGCGGCCGCGGCGTCTTAAGCGGCGCCCAGTGCAGGATGGTGC
  TGGAGGCGGCGGCGGCCGTGGTGGCGGCAGCGTCGTTGGCGGCAGCGGGAGTGGGTGCGG
  CGGCAGCGGCGGCGGCGCCCGCGGGTGGTATAAAATGGCGGATTTCGAAGAGTTGAGGAA
  TATGGTTTCTAGTTTTAGGGTTTCTGAACTACAAGTATTACTAGGCTTTGCTGGACGGAA
  TAAAAGTGGACGCAAGCATGACCTCTTTTTTTTTGGTGGCTGCATTTATTGAATATTTTT
  TGCAGCCCTGCGGTTCAGATTAAAATCCGAGAATTGTATAGACGCCGATATCCACGAACT
  CTTGAAGGACTTTCTGATTTATCCACAATCAAATCATCGGTTTTCAGTTTGGATGGTGGC
  TCATCACCTGTAGAACCTGACTTGGCCGTGGCTGGAATCCACTCGTTGCCTTCCACTTCA
  GTTACACCTCACTCACCATCCTCTCCTGTTGGTTCTGTGCTGCTTCAAGATACTAAGCCC
  ACATTATGAGATGCAAGCAGCCATCTCCCCCAATTCCTCCTGTCCATCCCTGATGTGCAG
  TTAAAAAATCTGCCCTTTTATGATGTCCCTTGATGTTCTCATCAAGCCCCACGAGTTTAG
  TTCAAAGCAGTATTCAGCCGATTTCAAGAGAAGTTTTTTTATTTTTTGCTTTGTACACCC
  TCAACCAAGTTAGAGAAGATATGGCATATCCAGGGAATTTTTTTGCCAGTTGTAGAAAGA
  ATTATACAGTCCAGTCAGTGGAGACTTAGGCCTGCAGAGACAGTTGCCTTCAGAGATAAC
  CTATCCATAGTCTATTGTATAAAGTAATGGAAGCAATCATGCCTGGCTATGGTCACCCGC
  CTAAAATGGAGAATTGGACCAGAAGCCGCACCTGCA
• Restriction Sites: Please inquire
• ACCN: NM_173206
• ORF Size: 1719 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_173206.2, NP_775298.1
• RefSeq Size: 1919
• RefSeq ORF: 1719
• Locus ID: 9063
• Protein Families: Stem cell - Pluripotency, Stem cell relevant signaling - JAK/STAT signaling pathway, Transcription Factors
• Protein Pathways: Jak-STAT signaling pathway, Pathways in cancer, Small cell lung cancer, Ubiquitin mediated proteolysis
• Gene Summary: This gene encodes a member of the protein inhibitor of activated STAT family, which function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2017]
  Transcript Variant: This variant (alpha) utilizes an alternate 3' coding exon, compared to variant beta, resulting in a shorter isoform (alpha) that has a unique C-terminus compared to isoform beta. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.