Sprouty 2 (SPRY2) (NM_005842) Human Untagged Clone

CAT#: SC321628

SPRY2 (untagged)-Human sprouty homolog 2 (Drosophila) (SPRY2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SPRY2
• Synonyms: hSPRY2; IGAN3
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_005842.2 ATCGCAGAAAGAAGAGAATCCAAGGGAGAGGGGTTGGTGCAAAGCCGCGATCACGGAGTT
  CAGATGTGTTCTAAGCCTGCTGGAGTGACCACACTTCCAAGACCTGATGGAGGCCAGAGC
  TCAGAGTGGCAACGGGTCGCAGCCCTTGCTGCAGACGCCCCGTGACGGTGGCAGACAGCG
  TGGGGAGCCCGACCCCAGAGACGCCCTCACCCAGCAGGTACATGTCTTGTCTCTGGATCA
  GATCAGAGCCATCCGAAACACCAATGAGTACACAGAGGGGCCTACTGTCGTCCCAAGACC
  TGGGCTCAAGCCTGCTCCTCGCCCCTCCACTCAGCACAAACACGAGAGACTCCACGGTCT
  GCCTGAGCACCGCCAGCCTCCTAGGCTCCAGCACTCGCAGGTCCATTCTTCTGCACGAGC
  CCCTCTGTCCAGATCCATAAGCACGGTCAGCTCAGGGTCGCGGAGCAGTACGAGGACAAG
  TACCAGCAGCAGCTCCTCTGAACAGAGACTGCTAGGATCATCCTTCTCCTCCGGGCCTGT
  TGCTGATGGCATAATCCGGGTGCAACCCAAATCTGAGCTCAAGCCAGGTGAGCTTAAGCC
  ACTGAGCAAGGAAGATTTGGGCCTGCACGCCTACAGGTGTGAGGACTGTGGCAAGTGCAA
  ATGTAAGGAGTGCACCTACCCAAGGCCTCTGCCATCAGACTGGATCTGCGACAAGCAGTG
  CCTTTGCTCGGCCCAGAACGTGATTGACTATGGGACTTGTGTATGCTGTGTGAAAGGTCT
  CTTCTATCACTGTTCTAATGATGATGAGGACAACTGTGCTGACAACCCATGTTCTTGCAG
  CCAGTCTCACTGTTGTACACGATGGTCAGCCATGGGTGTCATGTCCCTCTTTTTGCCTTG
  TTTATGGTGTTACCTTCCAGCCAAGGGTTGCCTTAAATTGTGCCAGGGGTGTTATGACCG
  GGTTAACAGGCCTGGTTGCCGCTGTAAAAACTCAAACACAGTTTGCTGCAAAGTTCCCAC
  TGTCCCCCCTAGGAACTTTGAAAAACCAACATAGCATCATTAATCAGGAATATTACAGTA
  ATGAGGATTTTTTCTTTCTTTTTTTAATACACATATGCAACCAACTAAACAGTTATAATC
  TTGGCACTGTTAATAGAAAGGTGGGATAGTCTTTGCTGTTTGCGGTGAAATGCTTTTTGT
  CCATGTGCCGTTTTAACTGATATGCTTGTTAGAACTCAGCTAATGGAGCTCAAAGTATGA
  GATACAGAACTTGGTGACCCATGTATTGCATAAGCTAAAGCAACACAGACACTCCTAGGC
  AAAGTTTTTGTTTGTGAATAGTACTTGCAAAACTTGTAAATTAGCAGATGACTTTTTTCC
  ATTGTTTTCTCCAGAGAGAATGTGCTATATTTTTGTATATACAATAATATTTGCAACTGT
  GAAAAACAAGTTGTGCCATACTACATGGCACAGACACAAAATATTATACTAATATGTTGT
  ACATTCGGAAGAATGTGAATCAATCAGTATGTTTTTAGATTGTATTTTGCCTTACAGAAA
  GCCTTTATTGTAAGACTCTGATTTCCCTTTGGACTTCATGTATATTGTACAGTTACAGTA
  AAATTCAACCTTTATTTTCTAATTTTTTCAACATATTGTTTAGTGTAAAGAATATTTATT
  TGAAGTTTTATTATTTTATAAAAAAGAATATTTATTTTAAGAGGCATCTTACAAATTTTG
  CCCCTTTTATGAGGATGTGATAGTTGCTGCAAATGAGGGGTTACAGATGCATATGTCCAA
  TATAAAATAGAAAATATATTAACGTTTGAAATTAAAAAAAAAAAAAAAAAAAAAAAAAAA
  AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_005842.2 unedited
  GGCGATTGTATACGACTCCTATAGGGCGGCCGGGAAATTCGGCACGAGGATCGCAGAAAG
  AAGAGAATCCAAGGGAGAGGGGTTGGTGCAAAGCCGCGATCACGGAGTTCAGATGTGTTC
  TAAGCCTGCTGGAGTGACCACACTTCCAAGACCTGATGGAGGCCAGAGCTCAGAGTGGCA
  ACGGGTCGCAGCCCTTGCTGCAGACGCCCCGTGACGGTGGCAGACAGCGTGGGGAGCCCG
  ACCCCAGAGACGCCCTCACCCAGCAGGTACATGTCTTGTCTCTGGATCAGATCAGAGCCA
  TCCGAAACACCAATGAGTACACAGAGGGGCCTACTGTCGTCCCAAGACCTGGGCTCAAGC
  CTGCTCCTCGCCCCTCCACTCAGCACAAACACGAGAGACTCCACGGTCTGCCTGAGCACC
  GCCAGCCTCCTAGGCTCCAGCACTCGCAGGTCCATTCTTCTGCACGAGCCCCTCTGTCCA
  GATCCATAAGCACGGTCAGCTCAGGGTCGCGGAGCAGTACGAGGACAAGTACCAGCAGCA
  GCTCCTCTGAACAGAGACTGCTAGGATCATCCTTCTCCTCCGGGCCTGTTGCTGATGGCA
  TAATCCGGGTGCAACCCAAATCTGAGCTCAAGCCAGTGAGCTTAAGCCACTGAGCAAGGA
  AGATTTGGGCCTGCACGCCTACAGGTGTGAGGACTGTGGCAAGTGCAAATGTAAGAGTGC
  ACCTACCCAAGGCCTCTGCCATCAGACTGGATCTGCGACAAGCAGTGCCTTTGCTCGGCC
  CAGACGTGATTGACTATGGGACTTGGTGTTATGCTGTTGTGAAAGTCTTCTTTCTATCAC
  TGTTTCTAATGATGATGAGACAACTTGTGCTGACAAACCATGTTCTGCAGCAGTTCTACT
  GTTGTACCCGATGTTCAGCCATGGGGTGTCAGTCCCTCTTTTTGGCCCTGGTTTTATTG
• Restriction Sites: Please inquire
• ACCN: NM_005842
• ORF Size: 948 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_005842.2, NP_005833.1
• RefSeq Size: 2126
• RefSeq ORF: 948
• Locus ID: 10253
• Domains: Sprouty
• Protein Families: Druggable Genome
• Protein Pathways: Jak-STAT signaling pathway
• Gene Summary: This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (1) represents the predominant transcript. Transcript variants 1-4 encode the same protein.