SERPINB8 (NM_001031848) Human Untagged Clone

CAT#: SC321661

SERPINB8 (untagged)-Human serpin peptidase inhibitor, clade B (ovalbumin), member 8 (SERPINB8), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SERPINB8
• Synonyms: C18orf53; CAP2; PI-8; PI8; PSS5
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_001031848.1 GTCAAAGCAGCAGCGGCGGCGGCGGCGGCGGCAGCAGCAGCAGCAGCAGGAGACCTTCTC
  TGATGGATGACCTCTGTGAAGCAAATGGCACTTTTGCCATCAGCTTATTTAAAATATTGG
  GGGAAGAGGACAACTCAAGAAACGTATTCTTCTCTCCCATGAGCATCTCCTCTGCCCTGG
  CCATGGTCTTCATGGGGGCAAAGGGAAGCACTGCAGCCCAGATGTCCCAGGCACTTTGTT
  TATACAAAGACGGAGATATTCACCGAGGTTTCCAGTCACTTCTCAGTGAAGTTAACAGAA
  CTGGCACTCAGTACTTGCTTAGAACTGCCAACAGACTCTTTGGAGAAAAGACGTGTGATT
  TCCTTCCAGACTTTAAAGAATACTGTCAGAAGTTCTATCAGGCAGAGCTGGAGGAGTTGT
  CCTTTGCTGAAGACACTGAAGAGTGCAGGAAGCATATAAATGACTGGGTGGCAGAGAAGA
  CTGAAGGTAAGATTTCAGAGGTACTGGATGCTGGGACAGTCGATCCCCTGACAAAGCTAG
  TCCTTGTGAATGCCATTTATTTCAAGGGAAAGTGGAATGAGCAATTTGACAGAAAGTACA
  CAAGGGGAATGCTCTTTAAAACCAACGAGGAAAAAAAGACAGTGCAGATGATGTTTAAGG
  AAGCTAAGTTTAAAATGGGGTATGCGGATGAGGTACACACCCAGGTCCTGGAGCTGCCCT
  ATGTGGAAGAGGAGCTGAGCATGGTCATTCTGCTTCCCGATGACAACACGGACCTCGCCG
  TGAAAGAGTGATGGATCTTGAAGAATTTGAAGCTAACTCCAGGACAGGCAGAGGACAAAC
  AAGGATGCTGATGAAGTCTTCTTGCATTCCCCATTTCTCGTCTCATGCTCCCTTCTCATG
  CCTCCCTTCATCTTCAGATGAAACACAATTCCCTCTCTTTTACTCTGAGTTGCCCTCTGA
  TTTAACCCTGAATAGTCCCCTCATTAGACTCAGAAGCAGAGTTCTGAGCCATGCTCTTTG
  TCTTTTGTCAAACAATCTCTCCCACTCACAGTAGTATGTATTGCATGAAGATTAATGTAA
  TGAATTGGTTAGAATTTTCTAAACTGTTAAAAAATGTTTTTAACATTTGAAAGGAGTTAG
  GTACAAATTGTTTTTATTAAAAATTTCTGCCTGTCTCAAAAAAAAAAAAAAAAAAAAAAA
  AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
• Restriction Sites: Please inquire
• ACCN: NM_001031848
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001031848.1, NP_001027018.1
• RefSeq Size: 1409 bp
• RefSeq ORF: 729 bp
• Locus ID: 5271
• Cytogenetics: 18q22.1
• Protein Families: Druggable Genome
• Gene Summary: 'The protein encoded by this gene is a member of the ov-serpin family of serine protease inhibitors. The encoded protein is produced by platelets and can bind to and inhibit the function of furin, a serine protease involved in platelet functions. In addition, this protein has been found to enhance the mechanical stability of cell-cell adhesion in the skin, and defects in this gene have been associated with an autosomal-recessive form of exfoliative ichthyosis. [provided by RefSeq, Jan 2017]'
  Transcript Variant: This variant (3) uses an alternate splice junction in the 5' UTR and has an alternate 3'-most exon compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.