Syntrophin alpha 1 (SNTA1) (NM_003098) Human Untagged Clone

CAT#: SC321683

SNTA1 (untagged)-Human syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) (SNTA1)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SNTA1
• Synonyms: dJ1187J4.5; LQT12; SNT1; TACIP1
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_003098.2 GGCGGCTGGCCCAGCCGGGCCCCCGCTGCCCTCTGCCCTGGGCGCTTGGTCGGAGCGGGC
  TGGGCAAAGCGGGACAGGGCGAGCGCGGCGGCCCGGGGGCTCGGAGGCGAAGATGGCGTC
  CGGCAGGCGCGCCCCGCGCACCGGGCTGCTGGAGCTGCGCGCCGGGGCGGGCTCGGGGGC
  CGGCGGCGAGCGATGGCAGCGGGTGCTGCTGAGTCTGGCGGAGGACGTGCTGACCGTGAG
  CCCCGCCGACGGCGACCCTGGTCCCGAGCCCGGCGCTCCGCGGGAGCAGGAGCCCGCGCA
  GCTCAACGGCGCCGCGGAGCCGGGCGCCGGGCCCCCGCAGCTGCCAGAGGCGCTACTGCT
  CCAGCGGCGCCGCGTGACGGTGCGCAAGGCCGACGCCGGTGGGCTGGGCATCAGCATCAA
  AGGCGGCCGGGAGAACAAGATGCCTATTCTCATTTCCAAGATCTTCAAGGGATTGGCAGC
  TGACCAGACAGAGGCCCTTTTTGTGGGGGATGCCATCCTGTCTGTGAATGGGGAAGACTT
  GTCCTCTGCTACCCATGATGAGGCGGTGCAGGTCCTCAAGAAGACAGGCAAGGAGGTGGT
  GCTGGAGGTCAAGTATATGAAGGACGTCTCACCGTATTTCAAGAACTCTACTGGTGGGAC
  CTCGGTCGGCTGGGACTCACCTCCTGCCTCACCCCTTCAGCGGCAGCCTTCCTCCCCTGG
  CCCCACACCCCGGAACTTCAGCGAGGCCAAACACATGTCCTTGAAGATGGCATATGTCTC
  GAAGAGGTGCACCCCCAATGACCCGGAGCCCAGGTATCTGGAGATCTGCTCGGCAGATGG
  TCAAGACACCCTCTTCCTGAGGGCCAAGGATGAGGCTAGTGCGAGGTCGTGGGCGACTGC
  CATCCAAGCCCAGGTCAATACTCTGACGCCGCGGGTCAAGGATGAGCTGCAGGCACTGTT
  GGCAGCCACCAGCACAGCTGGGAGCCAGGACATCAAGCAGATTGGCTGGCTAACTGAGCA
  GCTGCCCAGTGGGGGCACAGCCCCCACCCTGGCCCTGCTAACTGAAAAGGAACTGCTCCT
  CTACTTGTCTCTCCCCGAGACCCGCGAGGCCCTGAGCCGGCCAGCCCGTACTGCCCCACT
  CATCGCCACCAGACTGGTGCACTCAGGCCCCTCCAAGGGCTCAGTGCCCTACGATGCAGA
  GCTCTCTTTTGCCCTGCGCACGGGCACGCGTCACGGTGTGGACACTCACCTGTTCAGCGT
  GGAGTCACCGCAGGAGCTGGCTGCCTGGACCCGCCAGCTTGTGGATGGCTGTCACCGGGC
  CGCCGAGGGTGTGCAGGAGGTGTCTACAGCCTGCACGTGGAATGGGCGTCCCTGCAGCCT
  GTCTGTGCACATCGACAAGGGCTTCACACTGTGGGCGGCTGAGCCAGGTGCAGCCCGAGC
  TGTGCTCCTGCGACAGCCCTTCGAGAAGCTGCAGATGTCTTCAGATGACGGTGCCAGTCT
  CCTTTTCCTGGATTTTGGAGGTGCTGAAGGCGAGATCCAGCTGGACCTGCACTCGTGTCC
  CAAAACCATAGTCTTCATCATCCACTCCTTCCTGTCGGCCAAAGTCACCCGCCTCGGGCT
  GTTGGCCTAGAAGTCGCCGGATGCACTAGCCCTGAAGAGGGGTGTCCATGACATGGCCTG
  AGCTGGGCCTCCACCGACTGCCTGCTCACCCCTGGGCTGAGGGAAGGGAGAGGAGAGGAA
  CAAGGGCCTCCGAAACCCCAACCCTGAGGGAGACTGGATTGGTCTTGGGGCCCAGGACCC
  AGACGCAGGACAGAGTGGACTCTGCCTGTGATGGGGTGGCCTTCCTGCTGCCCCCCTCCA
  CCAGTGCCTTTTGCAGAGAGATATTTTGTGTACACAGAAGCCATTCCGAGTCTGGGACCT
  GCCCCTGTGCGGATCCTGACCCCAGCCAACAGCTGAGCTGCCGGGCCTCCTCGAGGCCCC
  TAAGCCACCCCCAGAGGTCCCATCTGAAGCTGGAGTACCCTGGGGTCAGCAGCAAGAGAA
  AGAAGAGGAGATTTTCTGTTTGTTTTTCCCCTCAGCCCTGCCACCGTGGGGAGTCTGGTT
  TTTCTCTTCATCCTGTCTCTCTCCTCCTTACTCTTGGATAAATAAACAGCCTGTGAGCAC
  ACAGGCAGCCCGGAAAAAAAAAAAAAAAA
• Restriction Sites: Please inquire
• ACCN: NM_003098
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_003098.2, NP_003089.1
• RefSeq Size: 2345 bp
• RefSeq ORF: 1518 bp
• Locus ID: 6640
• Cytogenetics: 20q11.21
• Domains: PDZ, PH
• Gene Summary: 'Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue. [provided by RefSeq, Jan 2013]'