CHRFAM7A (NM_148911) Human Untagged Clone

CAT#: SC321716

CHRFAM7A (untagged)-Human CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion (CHRFAM7A), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CHRFAM7A
• Synonyms: CHRNA7; CHRNA7-DR1; D-10; NACHRA7
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_148911.1 CGTGGAGCGCGCCGGCTCGCTGCAGCTCCGGGACTCAACATGCGCTGCTCGCCGGGAGGC
  GTCTGGCTGGCGCTGGCCGCGTCGCTCCTGCACGTGTCCCTGCAAGGCGAGTTCCAGAGG
  AAGCTTTACAAGGAGCTGGTCAAGAACTACAATCCCTTGGAGAGGCCCGTGGCCAATGAC
  TCGCAACCACTCACCGTCTACTTCTCCCTGAGCCTCCTGCAGATCATGGACGTGGATGAG
  AAGAACCAAGTTTTAACCACCAACATTTGGCTGCAAATGGCATATTCAAGAGTTCCTGCT
  ACATCGATGTACGCTGGTTTCCCTTTGATGTGCAGCACTGCAAACTGAAGTTTGGGTCCT
  GGTCTTACGGAGGCTGGTCCTTGGATCTGCAGATGCAGGAGGCAGATATCAGTGGCTATA
  TCCCCAATGGAGAATGGGACCTAGTGGGAATCCCCGGCAAGAGGAGTGAAAGGTTCTATG
  AGTGCTGCAAAGAGCCCTACCCCGATGTCACCTTCACAGTGACCATGCGCCGCAGGACGC
  TCTACTATGGCCTCAACCTGCTGATCCCCTGTGTGCTCATCTCCGCCCTCGCCCTGCTGG
  TGTTCCTGCTTCCTGCAGATTCCGGGGAGAAGATTTCCCTGGGGATAACAGTCTTACTCT
  CTCTTACCGTCTTCATGCTGCTCGTGGCTGAGATCATGCCCGCAACATCCGATTCGGTAC
  CATTGATAGCCCAGTACTTCGCCAGCACCATGATCATCGTGGGCCTCTCGGTGGTGGTGA
  CAGTGATCGTGCTGCAGTACCACCACCACGACCCCGACGGGGGCAAGATGCCCAAGTGGA
  CCAGAGTCATCCTTCTGAACTGGTGCGCGTGGTTCCTGCGAATGAAGAGGCCCGGGGAGG
  ACAAGGTGCGCCCGGCCTGCCAGCACAAGCAGCGGCGCTGCAGCCTGGCCAGTGTGGAGA
  TGAGCGCCGTGGCGCCGCCGCCCGCCAGCAACGGGAACCTGCTGTACATCGGCTTCCGCG
  GCCTGGACGGCGTGCACTGTGTCCCGACCCCCGACTCTGGGGTAGTGTGTGGCCGCATGG
  CCTGCTCCCCCACGCACGATGAGCACCTCCTGCACGGTGGGCAACCCCCCGAGGGGGACC
  CGGACTTGGCCAAGATCCTGGAGGAGGTCCGCTACATTGCCAACCGCTTCCGCTGCCAGG
  ACGAAAGCGAGGCGGTCTGCAGCGAGTGGAAGTTCGCCGCCTGTGTGGTGGACCGCCTGT
  GCCTCATGGCCTTCTCGGTCTTCACCATCATCTGCACCATCGGCATCCTGATGTCGGCTC
  CCAACTTCGTGGAGGCCGTGTCCAAAGACTTTGCGTAACCACGCCTGGTTCTGTACATGT
  GGAAAACTCACAGATGGGCAAGGCCTTTGGCTTGGCGAGATTTGGGGGTGCTAATCCAGG
  ACAGCATTACACGCCACAACTCCAGTGTTCCCTTCTGGCTGTCAGTCGTGTTGCTTACGG
  TTTCTTTGTTACTTTAGGTAGTAGAATCTCAGCACTTTGTTTCATATTCTCAGATGGGCT
  GATAGATATCCTTGGCACATCCGTACCATCGGTCAGCAGGGCCACTGAGTAGTCATTTTG
  CCCATTAGCCCACTGCCTGGAAAGCCCTTCGGAGAGCTCCCCATGGCTCCTCACCACCGA
  GACAGTTGGTTTTGCATGTCTGCATGAAGGTCTACCTGAAAATTCAACATTTGCTTTTTG
  CTTGTGTACAAACCCAGATTGAAGCTAAAATAAACCAGACTCACTAAAAAAAAAAAAAAA
  AAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_148911.1 unedited
  GACCTTGTATACGACTCCTATAGGGCGGCAGGCAGATCGCGGCGCGCCGGTACCGGTCCG
  GAATTCCCGGGATCGTGGAGCGCGCCGGCTCGCTGCAACTCCGGGACTCAACATGCGCTG
  CTCGCCGGGAGGCGTCTGGCTGGCGCTGGCCGCGTCGCTCCTGCACGTGTCCCTGCAAGG
  CGAGTTCCATAGGAAGCTTTACAAGGAGCTGGTCAAGAACTACAATCCCTTGGAGAGGCC
  CGTGGCCAATGACTCGCAGCCACTCACCGTCTACTTCTCCCTGAGCCTCCTGCAGATCAT
  GGACGTGGATGAGAAGAACCAATTTTTTTTTTCCAACATTTGGCTGCAAATGGCATATTC
  AAGAGTTCCTGCTACATCGATGTACGCTGGTTTCCCTTTGATGTGCAGCACTGCAAACTG
  AAGTTTGGGTCCTGGTCTTACGGAGGCTGGTCCTTGGATCTGCAGATGCAGGAGGCAGAT
  ATCAGTGGCTATATCCCCAATGGAGAATGGGACCTACTGGGAATCGCCGGCAAGAGGAGT
  GAAAGGTTCTATGAGTGCTGCAAAGAGCACTACACCGATGTCACCTTCACAGTGACCATG
  CGCCGCAAGACGCTCTACTATGGCCTCAACCTGCTGATCCCCTGTGTGCTCATCTGCTGC
  CCTCGCCCTGCTGGTGTTCCTGCTTCCTGCAGATTCCCGGGGAGAAGATTTACCCTGGGG
  GAATAACAGTCTTACTATCTTCTTACCGTCTTCATGCTAGCTCGTGGGCTGAAATCATGC
  CCAGCATCATTCCGATTGCGGTTACCAATTGATAGCCCTATGTGACTTATCTAGCACCAC
  TGATTCATCGTTGGGCCTCTTCGGTGGCTGGGTGACAGATGGAATCGTGCTGGCAGTTAC
  CACTCGACCACGATCCCCGACTGGGGGCTAAGAATGCCAGGTCGATCAGAAGTGTCTCTT
  CTGACCTTGTTGCCTTGGTTCTGGCAATCTGAAAAAGTTTCG
• Restriction Sites: Please inquire
• ACCN: NM_148911
• ORF Size: 966 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_148911.1, NP_683709.1
• RefSeq Size: 2794
• RefSeq ORF: 966
• Locus ID: 89832
• Domains: Neur_chan_memb
• Protein Families: Druggable Genome, Ion Channels: Other, Transmembrane
• Gene Summary: The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (2) lacks an internal exon compared to variant 1, and is missing the translation initiation site used by the longer variant. Translation from variant 2 initiates at a downstream site relative to variant 1, resulting in isoform (2), which is truncated at the N-terminus compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.