STING (TMEM173) (NM_198282) Human Untagged Clone

CAT#: SC321845

TMEM173 (untagged)-Human transmembrane protein 173 (TMEM173), nuclear gene encoding mitochondrial protein

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TMEM173
• Synonyms: ERIS; hMITA; hSTING; MITA; MPYS; NET23; SAVI; STING; STING-beta
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_198282.1 GCATCCTGGTAACCAGAAGAAAAATATGAGACGGGGAATCATCGTGTGATGTGTGTGCTG
  CCTTTGGCTGAGTGTGTGGAGTCCTGCTCAGGTGTTAGGTACAGTGTGTTTGATCGTGGT
  GGCTTGAGGGGAACCCGCTGTTCAGAGCTGTGACTGCGGCTGCACTCAGAGAAGCTGCCC
  TTGGCTGCTCGTAGCGCCGGGCCTTCTCTCCTCGTCATCATCCAGAGCAGCCAGTGTCCG
  GGAGGCAGAAGATGCCCCACTCCAGCCTGCATCCATCCATCCCGTGTCCCAGGGGTCACG
  GGGCCCAGAAGGCAGCCTTGGTTCTGCTGAGTGCCTGCCTGGTGACCCTTTGGGGGCTAG
  GAGAGCCACCAGAGCACACTCTCCGGTACCTGGTGCTCCACCTAGCCTCCCTGCAGCTGG
  GACTGCTGTTAAACGGGGTCTGCAGCCTGGCTGAGGAGCTGCGCCACATCCACTCCAGGT
  ACCGGGGCAGCTACTGGAGGACTGTGCGGGCCTGCCTGGGCTGCCCCCTCCGCCGTGGGG
  CCCTGTTGCTGCTGTCCATCTATTTCTACTACTCCCTCCCAAATGCGGTCGGCCCGCCCT
  TCACTTGGATGCTTGCCCTCCTGGGCCTCTCGCAGGCACTGAACATCCTCCTGGGCCTCA
  AGGGCCTGGCCCCAGCTGAGATCTCTGCAGTGTGTGAAAAAGGGAATTTCAACGTGGCCC
  ATGGGCTGGCATGGTCATATTACATCGGATATCTGCGGCTGATCCTGCCAGAGCTCCAGG
  CCCGGATTCGAACTTACAATCAGCATTACAACAACCTGCTACGGGGTGCAGTGAGCCAGC
  GGCTGTATATTCTCCTCCCATTGGACTGTGGGGTGCCTGATAACCTGAGTATGGCTGACC
  CCAACATTCGCTTCCTGGATAAACTGCCCCAGCAGACCGGTGACCATGCTGGCATCAAGG
  ATCGGGTTTACAGCAACAGCATCTATGAGCTTCTGGAGAACGGGCAGCGGGCGGGCACCT
  GTGTCCTGGAGTACGCCACCCCCTTGCAGACTTTGTTTGCCATGTCACAATACAGTCAAG
  CTGGCTTTAGCCGGGAGGATAGGCTTGAGCAGGCCAAACTCTTCTGCCGGACACTTGAGG
  ACATCCTGGCAGATGCCCCTGAGTCTCAGAACAACTGCCGCCTCATTGCCTACCAGGAAC
  CTGCAGATGACAGCAGCTTCTCGCTGTCCCAGGAGGTTCTCCGGCACCTGCGGCAGGAGG
  AAAAGGAAGAGGTTACTGTGGGCAGCTTGAAGACCTCAGCGGTGCCCAGTACCTCCACGA
  TGTCCCAAGAGCCTGAGCTCCTCATCAGTGGAATGGAAAAGCCCCTCCCTCTCCGCACGG
  ATTTCTCTTGAGACCCAGGGTCACCAGGCCAGAGCCTCCAGTGGTCTCCAAGCCTCTGGA
  CTGGGGGCTCTCTTCAGTGGCTGAATGTCCAGCAGAGCTATTTCCTTCCACAGGGGGCCT
  TGCAGGGAAGGGTCCAGGACTTGACATCTTAAGATGCGTCTTGTCCCCTTGGGCCAGTCA
  TTTCCCCTCTCTGAGCCTCGGTGTCTTCAACCTGTGAAATGGGATCATAATCACTGCCTT
  ACCTCCCTCACGGTTGTTGTGAGGACTGAGTGTGTGGAAGTTTTTCATAAACTTTGGATG
  CTAGTGTAAAAAAAAAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_198282.1 unedited
  GGCGTTTGTATACGACTCCTATAGGGCGGCGGGGATTCGCGGCGCGCCGGTACCGGTCCG
  GAATTCCCGGGATGCATCCTGGTAACCAGAAGAAAAATATGAGACGGGGAATCATCGTGT
  GATGTGTGTGCTGCCTTTGGCTGAGTGTGTGGAGTCCTGCTCAGGTGTTAGGTACAGTGT
  GTTTGATCGTGGTGGCTTGAGGGGAACCCGCTGTTCAGAGCTGTGACTGCGGCTGCACTC
  AGAGAAGCTGCCCTTGGCTGCTCGTAGCGCCGGGCCTTCTCTCCTCGTCATCATCCAGAG
  CAGCCAGTGTCCGGGAGGCAGAAGATGCTCCACTCCAGCCTGCATCCATCCATCCCGTGT
  CCCAGGGGTCACGGGGCCCAGAAGGCAGCCTTGGTTCTGCTGAGTGCCTGCCTGGTGACC
  CTTTGGGGGCTAGGAGAGCCACCAGAGCACACTCTCCGGTACCTGGTGCTCCACCTAGCC
  TCCCTGCAGCTGGGACTGCTGTTAAACGGGGTCTGCAGCCTGGCTGAGGAGCTGCGCCAC
  ATCCACTCCAGGTACCGGGGCAGCTACTGGAGGACTGTGCGGGCCTGCCTGGGCTGCCCC
  CTCCGCCGTGGGGCCCTGTTGCTGCTGTCCATCTATTTCTACTACTCCCTCCCAAATGCG
  GTCGGCCCGCCCTTCACTTGGATGCTTGCCCTCCTGGGCCTCTCGCAGGCACTGAACATC
  CTCCTGGGCCTCAAGGGCCTGGCCCCAGCTGAGATCTCTGCAGTGTGTGAAAAAGGGAAT
  TTCAACGTGGCCCATGGGCTGGCATGGTCATATTACATCGGATTATCTGCGGCTGATCCT
  GCCAGAGCTCCAGGCCCGGATTCGAACTTACAATCAGCATTAACAACAACCTGCTACGGG
  GTGCAATGAGCAGCGCTGTTTATTTTCTTCCTCCCATTGACTGTGGGGGGGTGCCTGTAT
  AACCTGGAGATTATGGGCTGTGAACCCA
• Restriction Sites: Please inquire
• ACCN: NM_198282
• ORF Size: 1140 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_198282.1, NP_938023.1
• RefSeq Size: 1714
• RefSeq ORF: 1140
• Locus ID: 340061
• Protein Pathways: Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway
• Gene Summary: This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
  Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).