PRKAG2 (NM_024429) Human Untagged Clone

CAT#: SC322089

PRKAG2 (untagged)-Human protein kinase, AMP-activated, gamma 2 non-catalytic subunit (PRKAG2), transcript variant b

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PRKAG2
• Synonyms: AAKG; AAKG2; CMH6; H91620p; WPWS
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for SC322089 GGGAATGACAGTTTGCTGCAGTCCCGTCAATGGGGGAATCTGCCCGAGCTCTGCCTGCAT
  TTTGAGCAGCAAAGCAGCTCCAGCCACCAAGACCGTTGCCTGCGCTGTCTTAGGCCAGCC
  CATGCTGTCTGCCAGCCGCTTGTTGCGCTGCCTTGGGGACTGGGGACACACCCAGCCCCG
  GTCCCCATCTGTTGCAGACATGCAGTGGCAGCAGCTCGGAGCACAGCCGAACCCTAGAAA
  TTGCCTGTGCTGAAGGGGCTGGGAAACCCCTTCTCTGATGGACCTTTCGAGTGAGGCAGC
  AGGATTTGTCAGAGCTGGGAGTGCCGCCCGTCCCCGTCACTCGCATCCTGCCATCCAGCA
  GCTTACAAGCCTGCACTGCTTATTAGCATCTGGAAGAGAAGACCTCCAGGACCCCTTGGG
  GCTGAGACCTGAGCTCCTTCGCCATGCCGCTCCTGGACGGAGACCTGGAGGGTTCCGGAA
  AGCATTCCTCTCGAAAGGTGGACAGCCCCTTCGGCCCGGGCAGCCCCTCCAAAGGGTTCT
  TCTCCAGAGGCCCCCAGCCCCGGCCCTCCAGCCCCATGTCTGCACCTGTGAGGCCCAAGA
  CCAGCCCCGGCTCTCCCAAAACCGTGTTCCCGTTCTCCTACCAGGAGTCCCCGCCACGCT
  CCCCTCGACGCATGAGCTTCAGTGGGATCTTCCGCTCCTCCTCCAAAGAGTCTTCCCCCA
  ACTCCAACCCTGCTACCTCGCCCGGGGGCATCAGGTTTTTCTCCCGCTCCAGAAAAACCT
  CCGGCCTCTCCTCCTCTCCGTCAACACCCACCCAAGTGACCAAGCAGCACACGTTTCCCC
  TGGAATCCTATAAGCACGAGCCTGAACGGTTAGAGAATCGCATCTATGCCTCGTCTTCCC
  CCCCAGACACAGGGCAGAGGTTCTGCCCGTCTTCCTTCCAGAGCCCGACCAGGCCTCCAC
  TGGCATCACCGACACACTATGCTCCCTCCAAAGCCGCGGCGCTGGCGGCGGCCCTGGGAC
  CCGCGGAAGCCGGCATGCTGGAGAAGCTGGAGTTCGAGGACGAAGCAGTAGAAGACTCAG
  AAAGTGGTGTTTACATGCGATTCATGAGGTCACACAAGTGTTATGACATCGTTCCAACCA
  GTTCAAAGCTTGTTGTCTTTGATACTACATTACAAGTTAAAAAGGCCTTCTTTGCTTTGG
  TAGCCAACGGTGTCAGAGCAGCGCCACTGTGGGAGAGTAAAAAACAAAGTTTTGTAGGAA
  TGCTAACAATTACAGATTTCATAAATATACTACATAGATACTATAAATCACCTATGGTAC
  AGATTTATGAATTAGAGGAACATAAAATTGAAACATGGAGGGAGCTTTATTTACAAGAAA
  CATTTAAGCCTTTAGTGAATATATCTCCAGATGCAAGCCTCTTCGATGCTGTATACTCCT
  TGATCAAAAATAAAATCCACAGATTGCCCGTTATTGACCCTATCAGTGGGAATGCACTTT
  ATATACTTACCCACAAAAGAATCCTCAAGTTCCTCCAGCTTTTTATGTCTGATATGCCAA
  AGCCTGCCTTCATGAAGCAGAACCTGGATGAGCTTGGAATAGGAACGTACCACAACATTG
  CCTTCATACATCCAGACACTCCCATCATCAAAGCCTTGAACATATTTGTGGAAAGACGAA
  TATCAGCTCTGCCTGTTGTGGATGAGTCAGGAAAAGTTGTAGATATTTATTCCAAATTTG
  ATGTAATTAATCTTGCTGCTGAGAAAACATACAATAACCTAGATATCACGGTGACCCAGG
  CCCTTCAGCACCGTTCACAGTATTTTGAAGGTGTTGTGAAGTGCAATAAGCTGGAAATAC
  TGGAGACCATCGTGGACAGAATAGTAAGAGCTGAGGTCCATCGGCTGGTGGTGGTAAATG
  AAGCAGATAGTATTGTGGGTATTATTTCCCTGTCGGACATTCTGCAAGCCCTGATCCTCA
  CACCAGCAGGTGCCAAACAAAAGGAGACAGAAACGGAGTGACCGCCGTGAATGTAGACGC
  CCTAGGAGGAGAACTTGAACAAAGTCTCTGGGTCACGTTTTGCCTCATGAACACTGGCTG
  CAAGTGGTTAAGAATGTATATCAGGGTTTAACGATAGGTATTTCTTCCAGTGATGTTGAA
  ATTAAGCTTAAAAAAGAAAGATTTTATGTGCTTGAAGATTCAGGCTTGCATTAAAAGACT
  GTTTTCAGACCTTTGTCTGAAGGATTTTAAATGCTGTATGTCATTAAAGTGCACTGTGTC
  CTGAAGTTTTCATTATTTTTCATTTCAAAGAATTCACTGGTATGGAACAGGTGATGTGGC
  ATAAGGTGAGTGCACGGTATGTTCAGATCACAGTGCCTTATGTCCGAATACAGCAATATG
  TCACCGCCGCAGCCGGGGCGCACGCGTGTGAAACAACACCGAGCTTGAATGTGGAAGTCT
  TTGAACCTTTTACCAAATCAGTTTGTTTTCTTTAGATTTGTCAAAAAGTTGTAATTTGAA
  TATAAATAATTACTTTAAAATTTTAATGACACTTTTACACGTAAGTGTTTTGTTCTGGGC
  TACCGTGTCAACGAGGCTGCTTTACAACAGCTTTATTTATTTTTACTTTCATGCAATTTT
  TTTACACATCTTTTGGTGGAGTAAACTTCACCACATCCATGAATAAACTCTCAGTTATTT
  TGAAATGGCAAATTTCTCATTATTTAAGTTTGGATCTGGAAAGGACATGACTTCTGAAAT
  AGCCGCTGCTGGGTTTTAAAAGCTGAGGTCTCTCAAAGTGTGGAGGAGACGTTGCAGTCA
  GGCGGGAGCCAAGTGCCGGGAAGATGTCTATTTTTTTTCTTGTGTATTGAAATGTAAAAT
  CATGATGTTTGTTATGACTGCTGATGCGATTGTTTTTGTAAATTTTATTGTGGCATATAC
  AGTATTGTCATACAGTTGAAGAGAAACAATGTTTCCTAATGTAAGTGCTCTGAAAATGTT
  GACACTGTATATATATATATGAGGATAGTTTGTTTTTTTTTGTTTTGGGTTTTTTTTTTT
  TCAGATTGAAAAATTAAAATAAATCCTACTATCTAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for SC322089 unedited
  GAGCTTTGTATACGACTCCTATAGGGCGGCGCGAACAACTTCGTATAGCATACATTATAC
  GAAGTTATGGATCAGGCCAAATCGGCCGAGCTCGAATTCGTCGAGAGCGGGGGAATGACA
  GTTTGCTGCAGTCCCGTCAATGGGGGAATCTGCCCGAGCTCTGCCTGCATTTTGAGCAGC
  AAAGCAGCTCCAGCCACCAAGACCGTTGCCTGCGCTGTCTTAGGCCAGCCCATGCTGTCT
  GCCAGCCGCTTGTTGCGCTGCCTTGGGGACTGGGGACACACCCAGCCCCGGTCCCCATCT
  GTTGCAGACATGCAGTGGCAGCAGCTTTTTTTTTTATCCGAACCCTAGAAATTGCCTGTG
  CTGAAGGGGCTGGGAAACCCCTTCTCTGATGGACCTTTCGAGTGAGGCAGCAGGATTTGT
  CAGAGCTGGGAGTGCCGCCCGTCCCCGTCACTCGCATCCTGCCATCCAGCAGCTTACAAG
  CCTGCACTGCTTATTAGCATCTGGAAGAGAAGACCTCCAGGACCCCTTGGGGCTGAGACC
  TGAGCTCCTTCGCCATGCCGCTCCTGGACGGAGACCTGGAGGGTTCCGGAAAGCATTCCT
  CTCGAAAGGTGGACAGCCCCTTCGGCCCGGGCAGCCCCTCCAAAGGGTTCTTCTCCAGAG
  GCCCCCAGCCCCGGCCCTCCAGCCCCATGTCTGCACCTGTGAGCCCAAGACCAGCCCCGG
  CTCTCCCAAACCGTGTTCCCGTTCTCCTACCAGAGTCCCGCCACGCTCCCTCGACGCATG
  AGCTTCAGTGGGATCTTCCGCTCCTCCTCAAAGAGTCTTCCCCACTCCAACCCTGCTACC
  TCGCCCGGGGCATCAGTTTTTTCTCCGCTCAGAAAACTCGGCCTTCCTCTTTCGTCAACC
  CACCAATGAACAGCAGCAACCGTTACCTTGATCTTATAAGCCAGACCCTGACGGTAGAGA
  AATC
• Restriction Sites: Please inquire
• ACCN: NM_024429
• ORF Size: 987 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_024429.1, NP_077747.1
• RefSeq Size: 2248
• RefSeq ORF: 987
• Locus ID: 51422
• Protein Families: Druggable Genome
• Protein Pathways: Adipocytokine signaling pathway, Hypertrophic cardiomyopathy (HCM), Insulin signaling pathway
• Gene Summary: AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family. Mutations in this gene have been associated with Wolff-Parkinson-White syndrome, familial hypertrophic cardiomyopathy, and glycogen storage disease of the heart. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2015]
  Transcript Variant: This variant (b) contains a distinct 5' UTR and lacks a large in-frame portion of the 5' coding region, compared to variant a. The resulting isoform (b, also referred to as PRKAG2-b) has a much shorter N-terminus when compared to isoform a. Variants b and e encode the same isoform (b).