PSTPIP1 (NM_003978) Human Untagged Clone

CAT#: SC322259

PSTPIP1 (untagged)-Human proline-serine-threonine phosphatase interacting protein 1 (PSTPIP1)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PSTPIP1
• Synonyms: CD2BP1; CD2BP1L; CD2BP1S; H-PIP; PAPAS; PSTPIP
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for SC322259 GCCTCCCACCCAGGGCTGGCATCCCTGCTCCCTGCCCTGGGTCCCAGACTGTGTCCTCCA
  TCACCGCAGGGTCGGTGAGGGGCTGGGCTGGACACCAGGGCCCGCCCTCCCATCACTGAG
  CTCCACTCCTTCCTCATTTTGCTGCTGATTCTAGCCCCAAACAAAACAGGTTGAGCTTTT
  TCCTCCCCTCAGAAGCTCCTCTCTGGCTCGTGGCTGCCTTCTGAGTGTTGCAGACGGCGC
  CGGCCGGGAAGGGGGGCCTGGGCCAGCCCTGCCAGGACTGGGACGCTGCTGCTGGCGCCT
  GGCCCTCCATCAGGCCAGCCTGTGGCAGGAGAGTGAGCTTTGCCGCGGCAGACGCCTGAG
  GATGATGCCCCAGCTGCAGTTCAAAGATGCCTTTTGGTGCAGGGACTTCACAGCCCACAC
  GGGCTACGAGGTGCTGCTGCAGCGGCTTCTGGATGGCAGGAAGATGTGCAAAGACATGGA
  GGAGCTACTGAGGCAGAGGGCCCAGGCGGAGGAGCGGTACGGGAAGGAGCTGGTGCAGAT
  CGCACGGAAGGCAGGTGGCCAGACGGAGATCAACTCCCTGAGGGCCTCCTTTGACTCCTT
  GAAGCAGCAAATGGAGAATGTGGGCAGCTCACACATCCAGCTGGCCCTGACCCTGCGTGA
  GGAGCTGCGGAGTCTCGAGGAGTTTCGTGAGAGGCAGAAGGAGCAGAGGAAGAAGTATGA
  GGCCGTCATGGACCGGGTCCAGAAGAGCAAGCTGTCGCTCTACAAGAAGGCCATGGAGTC
  CAAGAAGACATACGAGCAGAAGTGCCGGGACGCGGACGACGCGGAGCAGGCCTTCGAGCG
  CATTAGCGCCAACGGCCACCAGAAGCAGGTGGAGAAGAGTCAGAACAAAGCCAGGCAGTG
  CAAGGACTCGGCCACCGAGGCAGAGCGGGTATACAGGCAGAGCATTGCGCAGCTGGAGAA
  GGTCCGGGCTGAGTGGGAGCAGGAGCACCGGACCACCTGTGAGGCCTTTCAGCTGCAAGA
  GTTTGACCGGCTGACCATTCTCCGCAACGCCCTGTGGGTGCACAGCAACCAGCTCTCCAT
  GCAGTGTGTCAAGGATGATGAGCTCTACGAGGAAGTGCGGCTGACGCTGGAAGGCTGCAG
  CATAGACGCCGACATCGACAGTTTCATCCAGGCCAAGAGCACGGGCACAGAGCCCCCCGC
  TCCGGTGCCCTACCAGAACTATTACGATCGGGAGGTCACCCCGCTGACCAGCAGCCCTGG
  CATACAGCCGTCCTGCGGCATGATAAAGAGGTTCTCTGGACTGCTGCACGGAAGTCCCAA
  GACCACTTCGTTGGCAGCTTCTGCTGCGTCCACAGAGACCCTGACCCCCACCCCCGAGCG
  GAATGAGGGTGTCTACACAGCCATCGCAGTGCAGGAGATACAGGGAAACCCGGCCTCACC
  AGCCCAGGAGTACCGGGCGCTCTACGATTATACAGCGCAGAACCCAGATGAGCTGGACCT
  GTCCGCGGGAGACATCCTGGAGGTGATCCTGGAAGGGGAGGATGGCTGGTGGACTGTGGA
  GAGGAACGGGCAGCGTGGCTTCGTCCCTGGTTCCTACCTGGAGAAGCTTTGAGGAAGGGC
  CAGGAGCCCCTTCGGACCTGCCCTGCCAGTGGAGCCAGCAGTGCCCCCAGCACTGTCCCC
  ACCTTGCTAGGGCCCAGAACCAAGCGTCCCCCAGCCCCGAGAGGGAGCCTGTCGTCTCCC
  AGGGAATAAAGGAGTGCGTTCTGTTCAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for SC322259 unedited
  GGCCATTGTATACGACTCCTATAGGGCGGCCGGCGATCGCGGCGCGCCGGTACCGGTCCG
  GAATTCCCGGGATATCGTCGACCCACGCGTCCGGCCTCCCACCCAGGGCTGGCATCCCTG
  CTCCCTGCCCTGGGTCCCAGACTGTGTCCTCCATCACCGCAGGGTCGGTGAGGGGCTGGG
  CTGGACACCAGGGCCCGCCCTCCCATCACTGAGCTCCACTCCTTCCTCATTTTGCTGCTG
  ATTCTAGCCCCAAACAAAACAGGTTGAGCTTTTTCCTCCCCTCAGAAGCTCCTCTCTGGC
  TCGTGGCTGCCTTCTGAGTGTTGCAGACGGCGCCGGCCGGGAAGGGGGGCCTGGGCCAGC
  CCTGCCAGGACTGGGACGCTGCTGCTGGCGCCTGGCCCTCCATCAGGCCAGCCTGTGGCA
  GGAGAGTGAGCTTTGCCGCGGCAGACGCCTGAGGATGATGCCCCAGCTGCAGTTCAAAGA
  TGCCTTTTGGTGCAGGGACTTCACAGCCCACACGGGCTACGAGGTGCTGCTGCAGCGGCT
  TCTGGATGGCAGGAAGATGTGCAAAGACATGGAGGAGCTACTGAGGCAGAGGGCCCAGGC
  GGAGGAGCGGTACGGGAAGGAGCTGGTGCAGATCGCACGGAAAGCAGTGGCCAGACGGAG
  ATCAACTCCCTGAGGGCCTCCTTTGACTCCTTGAAGCAGCAAATGGAGAATGTGGGCAGC
  TCACACATCCAGCTGGCCCTGACCCTGCGTGAGGGAGCTGCGGAGTCTCGAGGGAGTTTC
  GTGGAGAGGCAGATGGAGCAGAGGAGAGTATGGAGGCCGTCATGGACCGGGTCCAGAGAG
  CAAGCTGTCGCTCTACAGAGGCATGGAGTCCAAGAAGAACTACGAGCCAGATGCGGACGC
  GGACGACCGGGAGCAGGCCTTCGAGCGCATTACGGCCAACGGTCACA
• Restriction Sites: Please inquire
• ACCN: NM_003978
• ORF Size: 1251 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_003978.2, NP_003969.2
• RefSeq Size: 1781
• RefSeq ORF: 1251
• Locus ID: 9051
• Domains: FCH, SH3
• Protein Families: Druggable Genome
• Protein Pathways: NOD-like receptor signaling pathway
• Gene Summary: This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response. [provided by RefSeq, Mar 2016]