Methionine Aminopeptidase 2 (METAP2) (NM_006838) Human Untagged Clone

CAT#: SC322467

METAP2 (untagged)-Human methionyl aminopeptidase 2 (METAP2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: METAP2
• Synonyms: MAP2; MNPEP; p67eIF2
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for SC322467 CTCTCGGGCAACATGGCGGGTGTGGAGGAGGTAGCGGCCTCCGGGAGCCACCTGAATGGC
  GACCTGGATCCAGACGACAGGGAAGAAGGAGCTGCCTCTACGGCTGAGGAAGCAGCCAAG
  AAAAAAAGACGAAAGAAGAAGAAGAGCAAAGGGCCTTCTGCAGCAGGGGAACAGGAACCT
  GATAAAGAATCAGGAGCCTCAGTGGATGAAGTAGCAAGACAGTTGGAAAGATCAGCATTG
  GAAGATAAAGAAAGAGATGAAGATGATGAAGATGGAGATGGCGATGGAGATGGAGCAACT
  GGAAAGAAGAAGAAAAAGAAGAAGAAGAAGAGAGGACCAAAAGTTCAAACAGACCCTCCC
  TCAGTTCCAATATGTGACCTGTATCCTAATGGTGTATTTCCCAAAGGACAAGAATGCGAA
  TACCCACCCACACAAGATGGGCGAACAGCTGCTTGGAGAACTACAAGTGAAGAAAAGAAA
  GCATTAGATCAGGCAAGTGAAGAGATTTGGAATGATTTTCGAGAAGCTGCAGAAGCACAT
  CGACAAGTTAGAAAATACGTAATGAGCTGGATCAAGCCTGGGATGACAATGATAGAAATC
  TGTGAAAAGTTGGAAGACTGTTCACGCAAGTTAATAAAAGAGAATGGATTAAATGCAGGC
  CTGGCATTTCCTACTGGATGTTCTCTCAATAATTGTGCTGCCCATTATACTCCCAATGCC
  GGTGACACAACAGTATTACAGTATGATGACATCTGTAAAATAGACTTTGGAACACATATA
  AGTGGTAGGATTATTGACTGTGCTTTTACTGTCACTTTTAATCCCAAATATGATACGTTA
  TTAAAAGCTGTAAAAGATGCTACTAACACTGGAATAAAGTGTGCTGGAATTGATGTTCGT
  CTGTGTGATGTTGGTGAGGCCATCCAAGAAGTTATGGAGTCCTATGAAGTTGAAATAGAT
  GGGAAGACATATCAAGTGAAACCAATCCGTAATCTAAATGGACATTCAATTGGGCAATAT
  AGAATACATGCTGGAAAAACAGTGCCGATTGTGAAAGGAGGGGAGGCAACAAGAATGGAG
  GAAGGAGAAGTATATGCAATTGAAACCTTTGGTAGTACAGGAAAAGGTGTTGTTCATGAT
  GATATGGAATGTTCACATTACATGAAAAATTTTGATGTTGGACATGTGCCAATAAGGCTT
  CCAAGAACAAAACACTTGTTAAATGTCATCAATGAAAACTTTGGAACCCTTGCCTTCTGC
  CGCAGATGGCTGGATCGCTTGGGAGAAAGTAAATACTTGATGGCTCTGAAGAATCTGTGT
  GACTTGGGCATTGTAGATCCATATCCACCATTATGTGACATTAAAGGATCATATACAGCG
  CAATTTGAACATACCATCCTGTTGCGTCCAACATGTAAAGAAGTTGTCAGCAGAGGAGAT
  GACTATTAAACTTAGTCCAAAGCCACCTCAACACCTTTATTTTCTGAGCTTTGTTGGAAA
  ACATGATACCAGAATTAATTTGCCACATGTTGTCTGTTTTAACAGTGGACCCATGTAATA
  CTTTTATCCATGTTTAAAAAAGAAGGAATTTGGACAAAGGCAAACCGTCTAATGTAATTA
  ACCAACGAAAAAGCTTTCCGGACTTTTAAATGCTAACTGTTTTTCCCCTTCCTGTCTAGG
  AAAATTCTATAAAGCTCAAATTAGTTAGGAATGACTTATACGTTTTGTTTTGAATACCTA
  AGAGATACTTTTTGGATATTTATATTGCCATATTCTTACTTGAATGCTTTGAATGACTAC
  ATCCAGTTCTGCACCTATACCCTCTGGTGTTGCTTTTTAACCTTCCTGGAATCCATTTTC
  TAAAAAATAAAGACATTTTCAGATCTGAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for SC322467 unedited
  GCTCATTTGTATACGACTCCTATAGGGCGGCCGGCGATCGCGGCGCGCCGGTACCGGTCC
  GGAATTCCCGGGATATCGTCGACCCACGCGTCCGCTCTCGGGCAACATGGCGGGTGTGGA
  GGAGGTAGCGGCCTCCGGGAGCCACCTGAATGGCGACCTGGATCCAGACGACAGGGAAGA
  AGGAGCTGCCTCTACGGCTGAGGAAGCAGCCAAGAAAAAAAGACGAAAGAAGAAGAAGAG
  CAAAGGGCCTTCTGCAGCAGGGGAACAGGAACCTGATAAAGAATCAGGAGCCTCAGTGGA
  TGAAGTAGCAAGACAGTTGGAAAGATCAGCATTGGAAGATAAAGAAAGAGATGAAGATGA
  TGAAGATGGAGATGGCGATGGAGATGGAGCAACTGGAAAGAAGAAGAAAAAGAAGAAGAA
  GAAGAGAGGACCAAAAGTTCAAACAGACCCTCCCTCAGTTCCAATATGTGACCTGTATCC
  TAATGGTGTATTTCCCAAAGGACAAGAATGCGAATACCCACCCACACAAGATGGGCGAAC
  AGCTGCTTGGAGAACTACAAGTGAAGAAAAGAAAGCATTAGATCAGGCAAGTGAAGAGAT
  TTGGAATGATTTTCGAGAAGCTGCAGAAGCACATCGACAAGTTAGAAAATACGTAATGAG
  CTGGATCAAGCCTGGGATGACAATGATAGAAATCTGTGAAAAGTTGGAAGACTGTTCACG
  CAAGTTAATAAAAGAGAATGGATTAAATGCAGGCCTGGCATTTCCTACTGGATGTTCTCT
  CAATAATTGTGCTGCCCATTATACTCCCAATGCCCGGTGACACACAGTATTACAGTATGA
  TGACATTCTGTAAAAATAGACTTTGGAACAACATATAGTGGTAGGATTATTGACCTGGTG
  CCTTTGACTGTCACTTTAATCCAATATTGAATACGTTATAAAAGCTGTAAGATGCTACTA
  ACACTGTATTAACTGTGGCTGAATTGAGTGTTTCGCTCTGGGTAAGTTTGGGT
• Restriction Sites: Please inquire
• ACCN: NM_006838
• ORF Size: 1437 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_006838.3, NP_006829.1
• RefSeq Size: 3506
• RefSeq ORF: 1437
• Locus ID: 10988
• Domains: Peptidase_M24
• Protein Families: Druggable Genome, Protease
• Gene Summary: The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of this gene is located on chromosome 2. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
  Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).