CHMP4B (NM_176812) Human Untagged Clone

CAT#: SC322662

CHMP4B (untagged)-Human chromatin modifying protein 4B (CHMP4B)


  "NM_176812" in other vectors (7)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol CHMP4B
Synonyms C20orf178; CHMP4A; CTPP3; CTRCT31; dJ553F4.4; Shax1; SNF7; SNF7-2; Vps32-2; VPS32B
Vector pCMV6-AC
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
>OriGene sequence for SC322662 GGCGGCAGGGAGCGGCGGGACTGGGAGCGGGCGCGGGAGCCGACCCGAGCCGAGCCGAGC
CGAGCCGAGCCGGAGCGGGCGGCGAAGGCCGGCGCGGCGAGCAGCAACCATGTCGGTGTT
CGGGAAGCTGTTCGGGGCTGGAGGGGGTAAGGCCGGCAAGGGCGGCCCGACCCCCCAGGA
GGCCATCCAGCGGCTGCGGGACACGGAAGAGATGTTAAGCAAGAAACAGGAGTTCCTGGA
GAAGAAAATCGAGCAGGAGCTGACGGCCGCCAAGAAGCACGGCACCAAAAACAAGCGCGC
GGCCCTCCAGGCACTGAAGCGTAAGAAGAGGTATGAGAAGCAGCTGGCGCAGATCGACGG
CACATTATCAACCATCGAGTTCCAGCGGGAGGCCCTGGAGAATGCCAACACCAACACCGA
GGTGCTCAAGAACATGGGCTATGCCGCCAAGGCCATGAAGGCGGCCCATGACAACATGGA
CATCGATAAAGTTGATGAGTTAATGCAGGACATTGCTGACCAGCAAGAACTTGCAGAGGA
GATTTCAACAGCAATTTCGAAACCTGTAGGGTTTGGAGAAGAGTTTGACGAGGATGAGCT
CATGGCGGAATTAGAAGAACTAGAACAGGAGGAACTAGACAAGAATTTGCTGGAAATCAG
TGGACCCGAAACAGTCCCTCTACCAAATGTTCCCTCTATAGCCCTACCATCAAAACCCGC
CAAGAAGAAAGAAGAGGAGGACGACGACATGAAGGAATTGGAGAACTGGGCTGGATCCAT
GTAATGGGGTCCAGCGCTGGCTGGGCCCAGACAGACTGTGGTGGCCTGCGCAGCGAGCAG
GCGTGTGCGTGTGTGGGGCAGGCAGGATGTGGTGCAGGCAGGTTCCATCGCTTTCGACTC
TCACTCCAAAGCAGTAGGGCCGCGTTGCTGCTCACTCTCTGCATAGCATGGTCTGCACCT
GGGAGATGGGCGGGGGGAGGGGGGCGGGCGGGGTGGGAAGTGCCTGCTGTTTATAATGTT
GAATTTCTGTAAAATAAACTGTATTTGCAAATCCAACATTGAGCTTCTGGACTACGCTGA
CTCCACTGCTGAATCCTCAATGGAAAGGGTCGACTGGTTGCAGTTGAAATGACCTGAAAT
GTAGCCTCTGTCCTTGTAAGTCAGTTGACTTGCCGCACATCTCTTTGTGTACTTGTACGG
TACTGGCAGAAAAGTCATTTTTCAAAAGCCATAGGCTTTTCCTTGCCCTTAGCTGTAATA
ATGCATCTGATTTTGATTTCCTCCAGAGCTGTGTTTCTGTCCATCACCTGTGTATTGGCC
CTGTGTTTACCACTCTGGCCCACTCCTCACCCCCTTGCTCCCCTGGTCTTCTGGAGTTTG
TGACATTGATTTGAAATGGATGGTGTTCTCTTGAGAGCAAGTGAGATTGTTAGAATTAAG
TTCCAACTATACAGTTTTCTAACATAGCTATAAGGTCCTTGTTGCTGTTTGTGATAACTG
ATAGATAACTCATTGGAAACGTGCATACATTTATATTCAGATGAAATTATGGTTTGCACT
GTCTATTAAATATCTCGATTAATTTTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAA
>OriGene 5' read for SC322662 unedited
GTTCTATTTTTGTATATTGTATACGACTCCTATAGGGGGGGAAAGATCGCGGCGCGCCGG
TCCGGTCCGGAATTCCCGGGATGGCGGCAGGGAGCGGCGGGACTGGGAGCGGGCGCGGGA
GCCGACCCGAGCCGAGCCGAGCCGAGCCGAGCCGGAGCGGGCGGCGAAGGCCGGCGCGGC
GAGCAGCAACCATGTCGGTGTTCGGGAAGCTGTTCGGGGCTGGAGGGGGTAAGGCCGGCA
AGGGCGGCCCGACCCCCCAGGAGGCCATCCAGCGGCTGCGGGACACGGAAGAGATGTTAA
GCAAGAAACAGGAGTTCCTGGAGAAGAAAATCTTTTCTTTGTTTCTGACGGCCGCCAAGA
AGCACGGCACCAAAAACAAGCGCGCGGCCCTCCAGGCACTGAAGCGTAAGAAGAGGTATG
AGAAGCAGCTGGCGCAGATCGACGGCACATTATCAACCATCGAGTTCCAGCGGGAGGCCC
TGGAGAATGCCAACACCAACACCGAGGTGCTCAAGAACATGGGCTATGCCGCCAAGGCCA
TGAAGGCGGCCCATGACAACATGGACATCGATAAAGTTGATGAGTTAATGCAGGACATTG
CTGACCAGCAAGAACTTGCAGAGGAGATTTCAACAGCAATTTCGAAACCCTGTAAGGGTT
TGGGAGAAGAGTTTGACGAGGATGAGCTCATGGGCGGGAATTTAGAGACTAGAACAGGAG
GAACTAGACAGAATTTGCTGGAAATCAGTGGACCCGAAACAGTCCCTCTACCAAATTGTC
CTCTTAAGCCTTACCATCAAAACCCGCCCAGAGAAAGAACAGGAGGACGACGACATGAAG
AAATTGGAAAACTGGCCTGATCCATGTTATGGGGTTCCAGCCGCTGGCCTTGGCCCCGCA
CGACTGTGTAGCTGGCCCACGAGCAGCCTGTGGCCTGTTTGGTTGCGA
Restriction Sites Please inquire     
ACCN NM_176812
ORF Size 675 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
Reference Data
RefSeq NM_176812.3, NP_789782.1
RefSeq Size 1685
RefSeq ORF 675
Locus ID 128866
Protein Pathways Endocytosis
Gene Summary This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts. [provided by RefSeq, Oct 2009]

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