SPG3A (ATL1) (NM_001127713) Human Untagged Clone

CAT#: SC323135

ATL1 (untagged)-Human atlastin GTPase 1 (ATL1), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ATL1
• Synonyms: AD-FSP; atlastin1; FSP1; GBP3; HSN1D; SPG3; SPG3A
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001127713, the custom clone sequence may differ by one or more nucleotides
  ATGGCCAAGAACCGCAGGGACAGAAACAGTTGGGGTGGATTTTCGGAAAAGACATATGAA
  TGGAGCTCAGAAGAGGAGGAGCCAGTGAAAAAGGCAGGACCAGTCCAAGTCCTCATTGTC
  AAAGATGACCATTCCTTTGAGTTAGATGAAACTGCATTAAATCGGATCCTTCTCTCGGAG
  GCTGTCAGAGACAAGGAGGTTGTTGCTGTATCTGTTGCTGGAGCATTTAGAAAAGGAAAA
  TCATTCCTGATGGACTTCATGTTGAGATACATGTACAACCAGGAATCAGTTGATTGGGTT
  GGAGACTACAATGAACCATTGACTGGTTTTTCATGGAGAGGTGGATCTGAGCGAGAGACC
  ACAGGAATTCAGATATGGAGTGAAATCTTCCTTATCAATAAACCTGATGGTAAAAAGGTT
  GCAGTGTTATTGATGGATACTCAGGGAACCTTTGATAGTCAGTCAACTTTGAGAGATTCA
  GCCACAGTATTTGCCCTTAGCACAATGATCAGCTCAATACAGGTATATAACTTATCCCAA
  AATGTCCAGGAGGATGATCTTCAGCACCTCCAGCTTTTCACTGAGTATGGCAGACTGGCA
  ATGGAGGAAACATTCCTGAAGCCATTTCAGAGTCTGATATTTCTTGTTCGAGACTGGAGT
  TTCCCATACGAATTTTCATATGGAGCCGATGGTGGTGCCAAATTCTTGGAAAAACGCCTC
  AAGGTCTCAGGGAACCAGCATGAAGAACTACAGAACGTCAGAAAACACATCCATTCCTGT
  TTCACCAACATTTCCTGTTTTCTGCTACCTCATCCTGGCTTAAAAGTAGCTACCAATCCA
  AACTTTGATGGAAAATTGAAAGAAATAGATGATGAATTCATCAAAAACTTGAAAATACTG
  ATTCCTTGGCTACTTAGTCCCGAGAGCCTAGATATTAAAGAGATCAATGGGAATAAAATC
  ACCTGCCGGGGTCTGGTGGAGTACTTCAAGGCTTATATAAAGATCTATCAAGGTGAAGAA
  TTACCACATCCCAAATCCATGTTACAGGCCACAGCAGAAGCTAACAATTTAGCAGCCGTG
  GCAACTGCCAAGGACACATACAACAAAAAAATGGAAGAGATTTGTGGTGGTGACAAACCA
  TTTCTGGCCCCAAATGACTTGCAGACCAAACACCTGCAACTTAAGGAAGAATCTGTGAAG
  CTATTCCGAGGGGTGAAGAAGATGGGTGGGGAAGAATTTAGCCGGCGTTACCTGCAGCAG
  TTGGAGAGTGAAATAGATGAACTTTACATCCAATATATCAAGCACAATGATAGCAAAAAT
  ATCTTCCATGCAGCTCGTACCCCAGCCACACTGTTTGTAGTCATCTTTATCACATATGTG
  ATTGCTGGTGTGACTGGATTCATTGGTTTGGACATCATAGCTAGCCTATGCAATATGATA
  ATGGGACTGACCCTTATCACCCTGTGCACTTGGGCATATATCCGGTACTCTGGAGAATAC
  CGAGAGCTGGGAGCTGTAATAGACCAGGTGGCTGCAGCTCTGTGGGACCAGGCTTTGTAC
  AAGCTTTACAGTGCAGCAGCAACCCACAGACATCTGTATCATCAAGCTTTCCCTACACCA
  AAGTCGGAATCTACTGAACAATCAGAAAAGAAAAAAATG
  
• Restriction Sites: Please inquire
• ACCN: NM_001127713
• ORF Size: 1662 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001127713.1, NP_001121185.1
• RefSeq Size: 2821
• RefSeq ORF: 1662
• Locus ID: 51062
• Protein Families: Druggable Genome, Transmembrane
• Gene Summary: The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (3) lacks an alternate in-frame exon and differs in the 5' UTR compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode isoform b.