Chloride Channel 5 (CLCN5) (NM_001127899) Human Untagged Clone

CAT#: SC323211

CLCN5 (untagged)-Human chloride channel 5 (CLCN5), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CLCN5
• Synonyms: ClC-5; CLC5; CLCK2; DENTS; hCIC-K2; NPHL1; NPHL2; XLRH; XRN
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001127899, the custom clone sequence may differ by one or more nucleotides
  ATGGCCATGTGGCAGGGTGCCATGGATAACAGAGGCTTTCAGCAGGGGAGTTTTAGTAGC
  TTCCAGAACAGCTCCAGTGATGAAGACCTGATGGACATTCCAGCAACCGCTATGGATTTC
  TCCATGAGAGATGATGTTCCTCCCTTAGACCGAGAAGTAGGAGAGGACAAGTCGTACAAT
  GGTGGAGGAATAGGTTCTTCAAATAGGATCATGGACTTCTTGGAGGAGCCAATCCCTGGT
  GTAGGGACCTATGATGATTTCAATACAATTGATTGGGTGAGAGAGAAGTCTCGAGACCGG
  GATAGGCACCGAGAGATTACCAATAAAAGCAAAGAGTCAACATGGGCCTTAATTCACAGT
  GTGAGTGATGCTTTTTCCGGCTGGTTGTTGATGCTCCTTATTGGGCTTTTATCAGGTTCG
  TTAGCTGGTTTGATAGACATCTCTGCTCATTGGATGACAGACTTAAAAGAAGGTATATGC
  ACAGGGGGATTCTGGTTTAACCATGAACATTGTTGCTGGAACTCTGAGCATGTCACCTTT
  GAAGAGAGAGACAAATGTCCAGAGTGGAATAGTTGGTCCCAGCTTATCATCAGCACAGAT
  GAGGGAGCCTTTGCCTACATAGTCAATTATTTCATGTACGTCCTCTGGGCTCTCCTATTT
  GCCTTCCTTGCCGTATCTCTTGTCAAGGTGTTTGCGCCTTATGCCTGTGGCTCTGGAATC
  CCTGAGATAAAAACTATCTTGAGTGGTTTCATTATTAGGGGCTATTTGGGTAAGTGGACT
  CTGGTTATCAAAACCATCACCTTGGTGCTGGCAGTGTCGTCTGGCTTGAGCCTGGGCAAA
  GAGGGCCCTCTAGTGCACGTGGCTTGCTGCTGTGGGAACATCCTGTGCCACTGCTTCAAC
  AAATACAGGAAGAATGAAGCCAAGCGCAGAGAGGTCTTGTCGGCTGCAGCAGCAGCTGGT
  GTATCTGTAGCCTTTGGAGCACCTATAGGTGGAGTATTATTCAGCCTTGAAGAGGTCAGC
  TACTATTTTCCCCTCAAAACATTGTGGCGTTCATTCTTTGCTGCCTTGGTGGCAGCATTC
  ACTCTACGCTCCATCAATCCATTTGGGAACAGCCGCCTGGTACTATTTTATGTGGAGTTT
  CACACCCCATGGCATCTCTTTGAGCTCGTGCCATTCATTCTGCTGGGCATATTTGGTGGT
  CTGTGGGGAGCACTGTTTATCCGCACAAACATTGCCTGGTGTCGGAAGCGAAAGACCACC
  CAGTTGGGCAAGTATCCTGTTATAGAGGTACTCGTCGTGACAGCCATCACTGCCATCCTG
  GCTTTCCCCAATGAATACACTCGGATGAGCACAAGTGAGCTCATTTCTGAGCTGTTTAAT
  GACTGTGGCCTTCTGGACTCCTCCAAGCTCTGTGATTATGAGAACCGTTTCAACACAAGC
  AAAGGGGGTGAACTGCCTGACAGACCGGCTGGCGTGGGAGTCTACAGTGCAATGTGGCAG
  CTGGCTTTAACACTCATACTGAAAATTGTCATTACTATATTCACCTTTGGCATGAAGATC
  CCTTCTGGCCTCTTTATCCCTAGCATGGCTGTTGGTGCTATAGCAGGTCGACTTCTAGGA
  GTAGGAATGGAACAGCTGGCTTATTACCACCAGGAATGGACCGTCTTCAATAGCTGGTGT
  AGTCAGGGAGCTGATTGCATCACCCCCGGCCTTTATGCAATGGTTGGGGCTGCAGCCTGC
  TTAGGTGGGGTGACTCGGATGACTGTTTCTCTTGTTGTCATAATGTTTGAACTGACTGGT
  GGCTTAGAATACATCGTGCCTCTGATGGCTGCAGCCATGACAAGCAAGTGGGTGGCAGAT
  GCTCTTGGGCGGGAGGGCATCTATGATGCCCACATCCGTCTCAATGGATACCCCTTTCTT
  GAAGCCAAAGAAGAGTTTGCTCATAAGACCCTGGCAATGGATGTGATGAAACCCCGGAGA
  AATGATCCTTTGTTGACTGTCCTTACTCAGGACAGTATGACTGTGGAAGATGTAGAGACC
  ATAATCAGTGAAACCACTTACAGTGGCTTCCCAGTGGTGGTATCCCGGGAGTCCCAAAGA
  CTTGTGGGCTTTGTCCTCCGAAGAGATCTCATTATTTCAATTGAAAATGCTCGAAAGAAA
  CAGGATGGGGTTGTTAGCACTTCCATCATTTATTTCACGGAGCATTCTCCTCCATTGCCA
  CCATACACTCCACCCACTCTAAAGCTTCGGAACATCCTCGATCTCAGCCCCTTCACTGTG
  ACTGACCTTACACCCATGGAGATCGTAGTGGATATTTTCCGAAAGCTGGGACTGCGGCAG
  TGCCTGGTTACACACAACGGGCGATTGCTTGGAATCATTACCAAAAAGGATGTGTTAAAG
  CATATAGCACAGATGGCGAACCAAGATCCTGATTCCATTCTCTTCAAC
  
• Restriction Sites: Please inquire
• ACCN: NM_001127899
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001127899.1, NP_001121371.1
• RefSeq Size: 10108 bp
• RefSeq ORF: 2451 bp
• Locus ID: 1184
• Cytogenetics: Xp11.23
• Protein Families: Druggable Genome, Ion Channels: Other, Transmembrane
• Gene Summary: 'This gene encodes a member of the ClC family of chloride ion channels and ion transporters. The encoded protein is primarily localized to endosomal membranes and may function to facilitate albumin uptake by the renal proximal tubule. Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]'
  Transcript Variant: This variant (1, also known as type 2) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 2 encode the same isoform. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.