STK39 (NM_013233) Human Untagged Clone

CAT#: SC323657

STK39 (untagged)-Kinase deficient mutant (K94M) of Human serine threonine kinase 39 (STE20/SPS1 homolog, yeast) (STK39)


  "NM_013233" in other vectors (7)

Reconstitution Protocol

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    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol STK39
Synonyms DCHT; PASK; SPAK
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>NCBI ORF sequence for NM_013233, the custom clone sequence may differ by one or more nucleotides


ATGGCGGAGCCGAGCGGCTCGCCCGTGCACGTCCAGCTTCCCCAGCAGGCGGCCCCGGTGACAGCGGCGG
CGGCGGCGGCCCCGGCGGCCGCGACAGCAGCGCCGGCCCCGGCAGCTCCCGCGGCCCCGGCCCCGGCCCC
GGCCCCGGCGGCACAGGCTGTCGGCTGGCCCATCTGCAGGGACGCGTACGAGCTGCAGGAGGTTATCGGC
AGTGGAGCTACTGCTGTGGTTCAGGCAGCCCTATGCAAACCCAGGCAAGAACGTGTAGCAATAAAACGGA
TCAACTTGGAAAAATGCCAGACCAGTATGGATGAACTATTAAAAGAAATTCAAGCCATGAGTCAGTGCAG
CCATCCCAACGTAGTGACCTATTACACCTCTTTTGTGGTCAAAGATGAACTTTGGCTGGTCATGAAATTA
CTAAGTGGAGGTTCAATGTTGGATATCATAAAATACATTGTCAACCGAGGAGAACACAAGAATGGAGTTC
TGGAAGAGGCAATAATAGCAACAATTCTTAAAGAGGTTTTGGAAGGCTTAGACTATCTACACAGAAACGG
TCAGATTCACAGGGATTTGAAAGCTGGTAATATTCTTCTGGGTGAGGATGGTTCAGTACAAATAGCAGAT
TTTGGGGTAAGTGCGTTCCTAGCAACAGGGGGTGATGTTACCCGAAATAAAGTAAGAAAAACATTCGTTG
GCACCCCATGTTGGATGGCTCCTGAAGTCATGGAACAGGTGAGAGGCTATGACTTCAAGGCTGACATGTG
GAGTTTTGGAATAACTGCCATTGAATTAGCAACAGGAGCAGCGCCTTATCACAAATATCCTCCCATGAAA
GTGTTAATGTTGACTTTGCAAAATGATCCACCCACTTTGGAAACAGGGGTAGAGGATAAAGAAATGATGA
AAAAGTACGGCAAGTCCTTTAGAAAATTACTTTCACTGTGTCTTCAGAAAGATCCTTCCAAAAGGCCCAC
AGCAGCAGAACTTTTAAAATGCAAATTCTTCCAGAAAGCCAAGAACAGAGAGTACCTGATTGAGAAGCTG
CTTACAAGAACACCAGACATAGCCCAAAGAGCCAAAAAGGTAAGAAGAGTTCCTGGGTCAAGTGGTCACC
TTCATAAAACCGAAGACGGGGACTGGGAGTGGAGTGACGACGAGATGGATGAGAAGAGCGAAGAAGGGAA
AGCAGCTTTTTCTCAGGAAAAGTCACGAAGAGTAAAAGAAGAAAATCCAGAGATTGCAGTGAGTGCCAGC
ACCATCCCCGAACAAATACAGTCCCTCTCTGTGCACGACTCTCAGGGCCCACCCAATGCTAATGAAGACT
ACAGAGAAGCTTCTTCTTGTGCCGTGAACCTCGTTTTGAGATTAAGAAACTCCAGAAAGGAACTTAATGA
CATACGATTTGAGTTTACTCCAGGAAGAGATACAGCAGATGGTGTATCTCAGGAGCTCTTCTCTGCTGGC
TTGGTGGATGGTCACGATGTAGTTATAGTGGCTGCTAATTTACAGAAGATTGTAGATGATCCCAAAGCTT
TAAAAACATTGACATTTAAGTTGGCTTCTGGCTGTGATGGGTCGGAGATTCCTGATGAAGTGAAGCTGAT
TGGGTTTGCTCAGTTGAGTGTCAGCTGA


>OriGene 5' read for mutant NM_013233 unedited
CCCGCCCGTTATCAGCAAAGGGCGGTAGGCGCTGTACGGCTGTGGAGGTCTATATAAGCAGAGCTCGTTT
AGTGAACCGTCAGAATCTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGTCCTAGCT
GGCTTCGGCGGGGACGGCGGCGGCGGCGGCGGCGGCGGCGGCGGGCGGGGAGGGCGTGCGCCGGCCGAGA
GGTGTCGGCGGCGAGGCAAAGGAAGTTTCAAGTGGAAGGTCGTCCGTCGGCCGGCGCGTCCTCCTGCTCT
CCTCCGCAGCATCATGGCGGAGCCGAGCGGCTCGCCCGTGCACGTCCAGCTTTCCCCAGCAGGCGGGCCC
CGGTGACAGCGGGCGGGCGGGCGGCGGCCCCGGCCCCGGCCCCGGCGGGCACAGGCTGTCGGCTTGGCCC
TCCTGCAGGGACGCGTACGAGCTGCAGGAGGGTTATCGGCAGTGGAACCTACTGGTGGTGGTTCAGGCAG
CCCAATGCCAAACCCAGGCAAAAAGTTGTACCATTAAGGCGGATCAACTTGAAAAATGCCGAACCAGTAG
GGATAAACTATAAAAGAAATTCACCATTGATTCATGGGCACCCCTCCCAACGGTGGACCTATTACCCCTT
TTTTGTTGTCAAATAAAATTTTGGCGTGGACATGAATTTCAAGGGGGGGTCAGTGTGATCTAAAACACTG
TGACCCCGAGAACACCAAGGATTCGAGAAAAGAAAAAAACAATCTCTAAGTGTTTGAGCGCAACACTATC
ACAACGCGCATCACAGAGTTAGACTGTGTATCTCTGTGGATGATGTAAAAAAAATTTTG
>SC323657 kinase domain raw sequence. By performing BLASTX analysis with this sequence against NCBI refernce protein database, you can confirm the presence of the kinase-deficient mutation
AAAACCAGSACKMGAGTWCGGCAGTGGAGCTACTGCTGTGGTTCAGGCAGCCCTATGCAAACCCAGGCAA
GAACGTGTAGCAATAATGCGGATCAACTTGGAAAAATGCCAGACCAGTATGGATGAACTATTAAAAGAAA
TTCAAGCCATGAGTCAGTGCAGCCATCCCAACGTAGTGACCTATTACACCTCTTTTGTGGTCAAAGATGA
ACTTTGGCTGGTCATGAAATTACTAAGTGGAGGTTCAATGTTGGA
Restriction Sites Please inquire     
ACCN NM_013233
ORF Size 1644 bp
Insert Size 3160
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation This kinase-deficient mutant clone was generated by created by site-directed mutagenesis from the corresponding wild-type clone. See details in "Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling." Cell. 2008 May p536-548.
Reference Data
RefSeq NM_013233.1, NP_037365.1
RefSeq Size 3293
RefSeq ORF 1644
Locus ID 27347
Domains pkinase, TyrKc, S_TKc
Protein Families Druggable Genome, Protein Kinase
Gene Summary This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008]

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