INPP5E (NM_019892) Human Untagged Clone

CAT#: SC323870

INPP5E (untagged)-Human inositol polyphosphate-5-phosphatase, 72 kDa (INPP5E)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: INPP5E
• Synonyms: CORS1; CPD4; JBTS1; MORMS; pharbin; PPI5PIV
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_019892.3 CTGGGCGGCCGGGCCTCCGCGAGTACCGGGTCGACTTCGGAGTCTGCGAGCCCAGCCAGG
  GGTGCCCGCTTCCCACCCCTCTCCCCGAGCGGCGTCCCCGTCGGGGTCGAACCTCCCCCG
  CGACAGGCGCCCAGCCGCCTGTTCCCCCAGGCCTTGCCTGCGGACCGCCCTGGGAACGGC
  GTCTGGGAGCCCCGAGGGGCTGGCGGGACTCGGGGCCCGGGCCATGCGGCAGCCGCCCCC
  GCCCCTCCGCGACCATCCCCGGCCCAAGCGGGAGCCGCAGCGGCGTTTCTGCTCCTCGCT
  GCGCCGGCGACCCCGGACCCGGCACCCGTGACCCCTCGCGCTGCCTGCGGCCTCGCGCCG
  AGGCCTGCCCCGGGAGAGACCGTCCATGCCGTCCAAGGCGGAGAATCTGCGGCCCTCCGA
  GCCGGCCCCGCAGCCGCCGGAAGGGAGGACGCTCCAAGGACAGCTTCCCGGCGCTCCGCC
  GGCCCAGCGCGCGGGGTCCCCACCCGATGCTCCGGGCTCCGAGAGCCCCGCGCTTGCCTG
  CAGCACTCCGGCCACGCCCAGCGGCGAGGACCCGCCAGCCCGAGCAGCACCCATCGCCCC
  GCGGCCCCCCGCCAGGCCTCGACTGGAGCGAGCCCTGTCCCTGGACGACAAGGGCTGGAG
  GAGGAGGCGTTTTCGAGGCAGCCAGGAGGACCTGGAAGCCCGGAATGGGACCAGTCCCTC
  CAGGGGCTCAGTGCAGAGCGAGGGCCCCGGGGCCCCCGCCCACAGCTGCTCCCCGCCCTG
  CCTGAGCACCTCCTTGCAGGAAATCCCCAAGTCCCGCGGGGTCCTGAGCAGTGAGAGAGG
  GAGCCCGTCCTCGGGGGGTAACCCTCTCTCTGGGGTGGCCAGCAGCTCCCCGAACCTCCC
  GCACAGAGACGCCGCCGTGGCGGGGAGCTCGCCCAGGCTGCCCAGCCTGCTGCCCCCGCG
  CCCACCGCCTGCCCTGAGCCTGGACATCGCCTCCGACTCCCTGAGGACAGCAAACAAGGT
  CGACTCGGATCTTGCAGACTACAAGCTCCGCGCGCAGCCGCTCCTGGTGCGGGCCCACAG
  CAGCCTGGGCCCCGGCCGGCCGCGGAGCCCCCTGGCCTGCGACGACTGTTCCCTTCGCTC
  GGCCAAATCCTCCTTCAGCCTCCTGGCGCCCATCCGCAGCAAGGACGTCCGCAGCAGGAG
  TTACCTGGAGGGCAGCCTCCTGGCCAGCGGGGCCCTGTTGGGGGCGGATGAGCTGGCCCG
  CTACTTCCCAGACCGGAACGTGGCACTCTTCGTGGCCACCTGGAACATGCAGGGCCAGAA
  GGAGCTCCCGCCCAGCCTGGACGAGTTCCTGCTCCCAGCCGAGGCCGACTATGCCCAGGA
  CCTGTATGTCATCGGGGTCCAGGAGGGCTGTTCTGACAGGCGGGAGTGGGAGACTCGTCT
  GCAGGAGACGCTGGGCCCGCACTATGTGCTGCTGTCCTCGGCGGCCCACGGCGTGCTCTA
  CATGTCGCTCTTCATCCGCAGGGACCTCATCTGGTTCTGCTCAGAGGTGGAGTGCTCCAC
  GGTGACCACACGCATCGTGTCTCAGATCAAGACCAAGGGGGCCTTGGGCATCAGCTTCAC
  CTTTTTTGGCACTTCCTTCCTCTTCATCACGTCCCACTTCACCTCAGGTGACGGGAAGGT
  GGCGGAGCGGCTGCTGGACTACACCAGGACTGTACAAGCCCTGGTCCTGCCCAGAAATGT
  GCCCGACACCAACCCCTATCGCTCCAGCGCAGCGGACGTCACCACCCGCTTCGATGAGGT
  GTTCTGGTTTGGAGACTTCAACTTCCGCCTGAGTGGCGGGCGCACAGTCGTGGACGCCCT
  CCTGTGCCAGGGCCTGGTGGTGGACGTGCCGGCGCTGCTGCAGCACGACCAGCTCATCCG
  GGAGATGCGGAAAGGGTCCATCTTCAAGGGCTTCCAGGAGCCGGACATCCACTTCCTCCC
  ATCATACAAGTTTGACATCGGGAAGGACACGTACGACAGCACCTCCAAGCAGAGGACGCC
  CTCATACACGGACCGCGTCTTGTACAGAAGCCGCCACAAGGGTGACATCTGTCCTGTGAG
  CTACTCTTCCTGCCCCGGGATCAAGACGTCCGACCACCGCCCTGTGTATGGCCTCTTCCG
  GGTGAAAGTGAGGCCGGGGCGAGACAACATTCCGTTGGCAGCTGGCAAATTTGATAGAGA
  ACTGTACTTACTAGGAATTAAAAGACGGATTTCGAAGGAGATTCAGAGGCAGCAAGCACT
  ACAGAGTCAGAACTCCAGCACCATCTGCTCCGTTTCTTGAAGTTTGCTGAACGAGGACTC
  ACAGCTGCAACGTGGGGTGATTGTATTGATCAAAACCCACTGGGAAGGACAAAGAGTTTG
  CCGCCTTTCGGGGATCCGAGGGACTGTGGCGACCGTGCCTCTGTGCCAGCGTCCCAGGAA
  GGAAGCCAACCCTGAGCGAGCCTGTCCTCTGTGGCAGGTCCACACGGTGTGGGTGGGCAG
  GGCTTGGACCCCCGTCTCCATGGCAGGTCCATACAGCATGGGTGGCAGGGTTTGGACCCG
  CCCAGCAGCACCACGGACCCCAGCCACTCTCGGGGGCAGACGTCAGAATCCGTTCCTGAG
  CAGCTCCTGTGCCCTGGGGGCAGTCACAGAGCCCCCCAACACCCCCGTGCTCTGCACCAG
  CCTCTCCCTCCACACCCGAAGCAGGCGTCCATCTGTGTCCTCCTGGCAGCCCCTCAAACA
  CACACCACCCCATGTCACACGGGTATCCAGAGCAAGGCTGGATCTGGGCTAGGTGACCCC
  TGGGGCCTCAGACCTCTGAGTGGGCCCCAGAGCCCAGCTGAGGAAGCCACACAGCCTCCA
  GGACGTGGCACGGTTCCCCTCCACTTGGCTGCAAGTCGCCTGCCATGGGGCGAGGAGGCC
  TGCACCCCAGTATAAGGGCCTCCCCAGCTGAGTAAGAAGCTGCTTCCCCTCCTCTCATAG
  GCCAAGCCTATTGTGTGAAACCATCTCATGGTCTTGGTGACGTAGACCATTTTTGAAACC
  GTCTCATGGTCTTGGTGACGTAGACCGTTTGCTTCTTTAACTCCAGCCGCGGAATGACAT
  TAGTGGAACCGGGCTAGGGAACTGCTGGAAGTTCAGGATGCCACCACCTTGAACACCTAG
  GCCAGGGATCCCCACCATGTCCCGGGTTTCTTTCTTCGAGAGTATAGAACCGTTCATTCT
  TGCTTTGTGTCCCATTCCATCTCTTGAAAAAATGTAGTCTTTGAATGTGTGAAAATCTAG
  GGACATTCAATCTAGTCTTTTAAATTATTTTTCCATATTTATATTTTTAAATAAATGCAT
  ATATTGAGTCTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  AAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_019892.3 unedited
  GACCATTGTATACGACTCCTATAGGGCGGCCGGCGATCGCGGCGCGCCGGTACCGGTCCG
  GAATTCCCGGGATCTGGGCGGCCGGGCCTCCGCGAGTACCGGGTCGACTTCGGAGTCTGC
  GAGCCCAGCCAGGGGTGCCCGCTTCCCACCCCTCTCCCCGAGCGGCGTCCCCGTCGGGGT
  CGAACCTCCCCCGCGACAGGCGCCCAGCCGCCTGTTCCCCCAGGCCTTGCCTGCGGACCG
  CCCTGGGAACGGCGTCTGGGAGCCCCGAGGGGCTGGCGGGACTCGGGGCCCGGGCCATGC
  GGCAGCCGCCCCCGCCCCTCCGCGACCATCCCCGGCCCAAGCTGTTAGTTAGTAGCGGCG
  TTTCTGCTCCTCGCTGCGCCGGCGACCCCGGACCCGGCACCTCGTGACCTGTCGCGCTGC
  CTGCGGCCTCGATTCTGTTGAATGACCCTGCATATTTCCTTTTCGGCCAAACTATTGGAA
  GTTTTCCCTACCTATCAGTCGGACCCATGCCTCGC
• Restriction Sites: ECoRI-NOT
• ACCN: NM_019892
• ORF Size: 1935 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_019892.3, NP_063945.2
• RefSeq Size: 3440
• RefSeq ORF: 1935
• Locus ID: 56623
• Protein Families: Druggable Genome
• Protein Pathways: Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system
• Gene Summary: The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
  Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).