CARD4 (NOD1) (NM_006092) Human Untagged Clone

CAT#: SC323936

NOD1 (untagged)-Human nucleotide-binding oligomerization domain containing 1 (NOD1)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: NOD1
• Synonyms: CARD4; CLR7.1; NLRC1
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_006092.1 CCCGGCCCCGGCGTCCCCGGACCATGGCGCTCTCCGGGCTCTTCTCTAGCTCTCAGCGGC
  TGCGAAGTCTGTAAACCTGGTGGCCAAGTGATTGTAAGTCAGGAGACTTTCCTTCGGTTT
  CTGCCTTTGATGGCAAGAGGTGGAGATTGTGGCGGCGATTACAGAAAACGTCTGGGAAGA
  CAAGTTGCTGTTTTTATGGGAATCGCAGGCTTGGAAGAGACAGAAGCAATTCCAGAAATA
  AATTGGAAATTGAAGATTTAAACAATGTTGTTTTAAAACATTCTAACTTCAAAGAATGAT
  GCCAGAAACTTAAAAAGGGGCTGCGCAGAGTAGCAGGGGCCCTGGAGGGCGCGGCCTGAA
  TCCTGATTGCCCTTCTGCTGAGAGGACACACGCAGCTGAAGATGAATTTGGGAAAAGTAG
  CCGCTTGCTACTTTAACTATGGAAGAGCAGGGCCACAGTGAGATGGAAATAATCCCATCA
  GAGTCTCACCCCCACATTCAATTACTGAAAAGCAATCGGGAACTTCTGGTCACTCACATC
  CGCAATACTCAGTGTCTGGTGGACAACTTGCTGAAGAATGACTACTTCTCGGCCGAAGAT
  GCGGAGATTGTGTGTGCCTGCCCCACCCAGCCTGACAAGGTCCGCAAAATTCTGGACCTG
  GTACAGAGCAAGGGCGAGGAGGTGTCCGAGTTCTTCCTCTACTTGCTCCAGCAACTCGCA
  GATGCCTACGTGGACCTCAGGCCTTGGCTGCTGGAGATCGGCTTCTCCCCTTCCCTGCTC
  ACTCAGAGCAAAGTCGTGGTCAACACTGACCCAGTGAGCAGGTATACCCAGCAGCTGCGA
  CACCATCTGGGCCGTGACTCCAAGTTCGTGCTGTGCTATGCCCAGAAGGAGGAGCTGCTG
  CTGGAGGAGATCTACATGGACACCATCATGGAGCTGGTTGGCTTCAGCAATGAGAGCCTG
  GGCAGCCTGAACAGCCTGGCCTGCCTCCTGGACCACACCACCGGCATCCTCAATGAGCAG
  GGTGAGACCATCTTCATCCTGGGTGATGCTGGGGTGGGCAAGTCCATGCTGCTACAGCGG
  CTGCAGAGCCTCTGGGCCACGGGCCGGCTAGACGCAGGGGTCAAATTCTTCTTCCACTTT
  CGCTGCCGCATGTTCAGCTGCTTCAAGGAAAGTGACAGGCTGTGTCTGCAGGACCTGCTC
  TTCAAGCACTACTGCTACCCAGAGCGGGACCCCGAGGAGGTGTTTGCCTTCCTGCTGCGC
  TTCCCCCACGTGGCCCTCTTCACCTTCGATGGCCTGGACGAGCTGCACTCGGACTTGGAC
  CTGAGCCGTGTGCCTGACAGCTCCTGCCCCTGGGAGCCTGCCCACCCCCTGGTCTTGCTG
  GCCAACCTGCTCAGTGGGAAGCTGCTCAAGGGGGCTAGCAAGCTGCTCACAGCCCGCACA
  GGCATCGAGGTCCCGCGCCAGTTCCTGCGGAAGAAGGTGCTTCTCCGGGGCTTCTCCCCC
  AGCCACCTGCGCGCCTATGCCAGGAGGATGTTCCCCGAGCGGGCCCTGCAGGACCGCCTG
  CTGAGCCAGCTGGAGGCCAACCCCAACCTCTGCAGCCTGTGCTCTGTGCCCCTCTTCTGC
  TGGATCATCTTCCGGTGCTTCCAGCACTTCCGTGCTGCCTTTGAAGGCTCACCACAGCTG
  CCCGACTGCACGATGACCCTGACAGATGTCTTCCTCCTGGTCACTGAGGTCCATCTGAAC
  AGGATGCAGCCCAGCAGCCTGGTGCAGCGGAACACACACAGCCCAGTGGAGACCCTCCAC
  GCCGGCCGGGACACTCTGTGCTCGCTGGGGCAGGTGGCCCACCGGGGCATGGAGAAGAGC
  CTCTTTGTCTTCACCCAGGAGGAGGTGCAGGCCTCCGGGCTGCAGGAGAGAGACATGCAG
  CTGGGCTTCCTGCGGGCTTTGCCGGAGCTGGGCCCCGGGGGTGACCAGCAGTCCTATGAG
  TTTTTCCACCTCACCCTCCAGGCCTTCTTTACAGCCTTCTTCCTCGTGCTGGACGACAGG
  GTGGGCACTCAGGAGCTGCTCAGGTTCTTCCAGGAGTGGATGCCCCCTGCGGGGGCAGCG
  ACCACGTCCTGCTATCCTCCCTTCCTCCCGTTCCAGTGCCTGCAGGGCAGTGGTCCGGCG
  CGGGAAGACCTCTTCAAGAACAAGGATCACTTCCAGTTCACCAACCTCTTCCTGTGCGGG
  CTGTTGTCCAAAGCCAAACAGAAACTCCTGCGGCATCTGGTGCCCGCGGCAGCCCTGAGG
  AGAAAGCGCAAGGCCCTGTGGGCACACCTGTTTTCCAGCCTGCGGGGCTACCTGAAGAGC
  CTGCCCCGCGTTCAGGTCGAAAGCTTCAACCAGGTGCAGGCCATGCCCACGTTCATCTGG
  ATGCTGCGCTGCATCTACGAGACACAGAGCCAGAAGGTGGGGCAGCTGGCGGCCAGGGGC
  ATCTGCGCCAACTACCTCAAGCTGACCTACTGCAACGCCTGCTCGGCCGACTGCAGCGCC
  CTCTCCTTCGTCCTGCATCACTTCCCCAAGCGGCTGGCCCTAGACCTAGACAACAACAAT
  CTCAACGACTACGGCGTGCGGGAGCTGCAGCCCTGCTTCAGCCGCCTCACTGTTCTCAGA
  CTCAGCGTAAACCAGATCACTGACGGTGGGGTAAAGGTGCTAAGCGAAGAGCTGACCAAA
  TACAAAATTGTGACCTATTTGGGTTTATACAACAACCAGATCACCGATGTCGGAGCCAGG
  TACGTCACCAAAATCCTGGATGAATGCAAAGGCCTCACGCATCTTAAACTGGGAAAAAAC
  AAAATAACAAGTGAAGGAGGGAAGTATCTCGCCCTGGCTGTGAAGAACAGCAAATCAATC
  TCTGAGGTTGGGATGTGGGGCAATCAAGTTGGGGATGAAGGAGCAAAAGCCTTCGCAGAG
  GCTCTGCGGAACCACCCCAGCTTGACCACCCTGAGTCTTGCGTCCAACGGCATCTCCACA
  GAAGGAGGAAAGAGCCTTGCGAGGGCCCTGCAGCAGAACACGTCTCTAGAAATACTGTGG
  CTGACCCAAAATGAACTCAACGATGAAGTGGCAGAGAGTTTGGCAGAAATGTTGAAAGTC
  AACCAGACGTTAAAGCATTTATGGCTTATCCAGAATCAGATCACAGCTAAGGGGACTGCC
  CAGCTGGCAGATGCGTTACAGAGCAACACTGGCATAACAGAGATTTGCCTAAATGGAAAC
  CTGATAAAACCAGAGGAGGCCAAAGTCTATGAAGATGAGAAGCGGATTATCTGTTTCTGA
  GAGGATGCTTTCCTGTTCATGGGGTTTTTGCCCTGGAGCCTCAGCAGCAAATGCCACTCT
  GGGCAGTCTTTTGTGTCAGTGTCTTAAAGGGGCCTGCGCAGGCGGGACTATCAGGAGTCC
  ACTGCCTCCATGATGCAAGCCAGCTTCCTGTGCAGAAGGTCTGGTCGGCAAACTCCCTAA
  GTACCCGCTACAATTCTGCAGAAAAAGAATGTGTCTTGCGAGCTGTTGTAGTTACAGTAA
  ATACACTGTGAAGAGACTTTATTGCCTATTATAATTATTTTTATCTGAAGCTAGAGGAAT
  AAAGCTGTGAGCAAACAGAGGAGGCCAGCCTCACCTCATTCCAACACCTGCCATAGGGAC
  CAACGGGAGCGAGTTGGTCACCGCTCTTTTCATTGAAGAGTTGAGGATGTGGCACAAAGT
  TGGTGCCAAGCTTCTTGAATAAAACGTGTTTGATGGATTAGTATTATACCTGAAATATTT
  TCTTCCTTCTCAGCACTTTCCCATGTATTGATACTGGTCCCACTTCACAGCTGGAGACAC
  CGGAGTATGTGCAGTGTGGGATTTGACTCCTCCAAGGTTTTGTGGAAAGTTAATGTCAAG
  GAAAGGATGCACCACGGGCTTTTAATTTTAATCCTGGAGTCTCACTGTCTGCTGGCAAAG
  ATAGAGAATGCCCTCAGCTCTTAGCTGGTCTAAGAATGACGATGCCTTCAAAATGCTGCT
  TCCACTCAGGGCTTCTCCTCTGCTAGGCTACCCTCCTCTAGAAGGCTGAGTACCATGGGC
  TACAGTGTCTGGCCTTGGGAAGAAGTGATTCTGTCCCTCCAAAGAAATAGGGCATGGCTT
  GCCCCTGTGGCCCTGGCATCCAAATGGCTGCTTTTGTCTCCCTTACCTCGTGAAGAGGGG
  AAGTCTCTTCCTGCCTCCCAAGCAGCTGAAGGGTGACTAAACGGGCGCCAAGACTCAGGG
  GATCGGCTGGGAACTGGGCCAGCAGAGCATGTTGGACACCCCCCACCATGGTGGGCTTGT
  GGTGGCTGCTCCATGAGGGTGGGGGTGATACTACTAGATCACTTGTCCTCTTGCCAGCTC
  ATTTGTTAATAAAATACTGAAAACACTAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_006092.1 unedited
  GTACATTTGTATACGACTCCTATAGGGCGGCCGGCGATCGCGGCGCGCCGGTACCGGTCC
  GGAATTCCCGGGATATCGTCGACCCACGCGTCCGCCCGGCCCCGGCGTCCCCGGACCATG
  GCGCTCTCCGGGCTCTTCTCTAGCTCTCAGCGGCTGCGAAGTCTGTAAACCTGGTGGCCA
  AGTGATTGTAAGTCAGGAGACTTTCCTTCGGTTTCTGCCTTTGATGGCAAGAGGTGGAGA
  TTGTGGCGGCGATTACAGAAAACGTCTGGGAAGACAAGTTGCTGTTTTTATGGGAATCGC
  AGGCTTGGAAGAGACAGAAGCAATTCCAGAAATAAATTGGAAATTGAAGATTTAAACAAT
  GTTGTTTTAAAACATTCTAACTTCAAAGAATGATGCCAGAAACTTAAAAAGGGGCTGCGC
  AGAGTAGCAGGGGCCCTGGAGGGCGCGGCCTGAATCCTGATTGCCCTTCTGCTGAGAGGA
  CACACGCAGCTGAAGATGAATTTGGGAAAAGTAGCCGCTTGCTACTTTAACTATGGAAGA
  GCAGGGCCACAGTGAGATGGAAATAATCCCATCAGAGTCTCACCCCCACATTCAATTACT
  GAAAAGCAATCGGGAACTTCTGGTCACTCACATCCGCAATACTCAGTGTCTGGTGGACAA
  CTTGCTGAAGAATGACTACTTCTCGGCCGAAGATGCGGAGATTGTGTGTGCCTGCCCCAC
  CCAGCCTGACAAGGTCCGCAAAATTCTGGACCTGGTACAGAGCAAGGGCGAGGAGGTGTC
  CGAGTTCTTCCTCTACTTGCTCCAGCAACTCGCAGATGCCTACGTGGACCTCAGCTGCTG
  CTGAGATCGGCTTCTCCCCTTCCCTGCTCACTCAGAGCAAGTCGTGGTCAACAACTGACC
  CAGGTGGAGCAGGTAATACCCCAGCAGCTGGCGACACCCATCTCTG
• Restriction Sites: ECoRI-NOT
• ACCN: NM_006092
• ORF Size: 2862 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_006092.1, NP_006083.1
• RefSeq Size: 4390
• RefSeq ORF: 2862
• Locus ID: 10392
• Domains: CARD, LRR, LRR_RI
• Protein Families: Druggable Genome
• Protein Pathways: Epithelial cell signaling in Helicobacter pylori infection, NOD-like receptor signaling pathway
• Gene Summary: This gene encodes a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family of proteins. The encoded protein plays a role in innate immunity by acting as a pattern-recognition receptor (PRR) that binds bacterial peptidoglycans and initiates inflammation. This protein has also been implicated in the immune response to viral and parasitic infection. Major structural features of this protein include an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. Mutations in this gene are associated with asthma, inflammatory bowel disease, Behcet disease and sarcoidosis in human patients. [provided by RefSeq, Aug 2017]