GPBAR1 (NM_001077191) Human Untagged Clone

CAT#: SC323958

GPBAR1 (untagged)-Human G protein-coupled bile acid receptor 1 (GPBAR1), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: GPBAR1
• Synonyms: BG37; GPCR19; GPR131; M-BAR; TGR5
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_001077191.1 GCAGAGCCTGGGTAGGAGAGCCTGGCCCCGCTGTCCCCACTGGGTGGAGACACCATGCAC
  TTGGTCCTTGTGCTCTTCAGCCAGGACACCAGACATGGTCCAAACCGCTGCAGGGCTGGC
  TGCAGCAACTCCCTGACACTCAGGAAGGCCCAGGCTGGGCAGGCAATACCTGCTCCCAAC
  AGCCATGCATGCCGGCTGCCGCTCCAGGACTCCCCTGTCCCCAGGACCAAGATGACGCCC
  AACAGCACTGGCGAGGTGCCCAGCCCCATTCCCAAGGGGGCTTTGGGGCTCTCCCTGGCC
  CTGGCAAGCCTCATCATCACCGCGAACCTGCTCCTAGCCCTGGGCATCGCCTGGGACCGC
  CGCCTGCGCAGCCCACCTGCTGGCTGCTTCTTCCTGAGCCTACTGCTGGCTGGGCTGCTC
  ACGGGTCTGGCATTGCCCACATTGCCAGGGCTGTGGAACCAGAGTCGCCGGGGTTACTGG
  TCCTGCCTCCTCGTCTACTTGGCTCCCAACTTCTCCTTCCTCTCCCTGCTTGCCAACCTC
  TTGCTGGTGCACGGGGAGCGCTACATGGCAGTCCTGAGGCCACTCCAGCCCCCTGGGAGC
  ATTCGGCTGGCCCTGCTCCTCACCTGGGCTGGTCCCCTGCTCTTTGCCAGTCTGCCCGCT
  CTGGGGTGGAACCACTGGACCCCTGGTGCCAACTGCAGCTCCCAGGCTATCTTCCCAGCC
  CCCTACCTGTACCTCGAAGTCTATGGGCTCCTGCTGCCCGCCGTGGGTGCTGCTGCCTTC
  CTCTCTGTCCGCGTGCTGGCCACTGCCCACCGCCAGCTGCAGGACATCTGCCGGCTGGAG
  CGGGCAGTGTGCCGCGATGAGCCCTCCGCCCTGGCCCGGGCCCTTACCTGGAGGCAGGCA
  AGGGCACAGGCTGGAGCCATGCTGCTCTTCGGGCTGTGCTGGGGGCCCTACGTGGCCACA
  CTGCTCCTCTCAGTCCTGGCCTATGAGCAGCGCCCGCCACTGGGGCCTGGGACACTGTTG
  TCCCTCCTCTCCCTAGGAAGTGCCAGTGCAGCGGCAGTGCCCGTAGCCATGGGGCTGGGC
  GATCAGCGCTACACAGCCCCCTGGAGGGCAGCCGCCCAAAGGTGCCTGCAGGGGCTGTGG
  GGAAGAGCCTCCCGGGACAGTCCCGGCCCCAGCATTGCCTACCACCCAAGCAGCCAAAGC
  AGTGTCGACCTGGACTTGAACTAAAGGAAGGGCCTCTGCTGACTCCTACCAGAGCATCCG
  TCCAGCTCAGCCATCCAGCCTGTCTCTACTGGGCCCCACTTCTCTGGATCAGAGACCCTG
  CCTCTGTTTGACCCCGCACTGACTGAATAAAGCTCCTCTGGCCGTTAAAAAAAAAAAAAA
  AAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_001077191.1 unedited
  GGCACCGCTGTATACGACCTCCTATAGGGCGGCCGGCGACTCGCGGCGCGCCGGTACCGG
  TCCGGAATTCCCGGGATGCAGAGCCTGGGTAGGAGAGCCTGGCCCCGCTGTCCCCACTGG
  GTGGAGACACCATGCACTTGGTCCTTGTGCTCTTCAGCCAGGACACCAGACATGGTCCAA
  ACCGCTGCAGGGCTGGCTGCAGCAACTCCCTGACACTCAGGAAGGCCCAGGCTGGGCAGG
  CAATACCTGCTCCCAACAGCCATGCATGCCGGCTGCCGCTCCAGGACTCCCCTGTCCCCA
  GGACCAAGATGACGCCCAACAGCACTGGCGAGGTGCCCAGCCCCATTCCCAAGGGGGCTT
  TGGGGCTCTCCCTGGCCCTGGCAAGCCTCATCATCACCGCGAACCTGCTCCTAGCCCTGG
  GCATCGCCTGGGACCGCCGCCTGCGCAGCCCACCTGCTGGCTGCTTCTTCCTGAGCCTAC
  TGCTGGCTGGGCTGCTCACGGGTCTGGCATTGCCCACATTGCCAGGGCTGTGGAACCAGA
  GTCGCCGGGGTTACTGGTCCTGCCTCCTCGTCTACTTGGCTCCCAACTTCTCCTTCCTCT
  CCCTGCTTGCCAACCTCTTGCTGGTGCACGGGGAGCGCTACATGGCAGTCCTGAGGCCAC
  TCCAGCCCCCTGGGAGCATTCGGCTGGCCCTGCTCCTCACCTGGCTGGTCCCCTGCTCTT
  TGCCAGTCTGCCCGCTCTGGGTGGAACCACTGGACCCCTGTGCCAACTGCAGCTCCCAGG
  CTATCTTCCCAGCCCCCTACCTTGTACCTCGAAGTTCTATGGGCTCCTGCTGCCCGCCGT
  GGGTGCTGCTGCCCTTCCTTCTCTGTCCGCGTGCTGCCACTGCCACCGGCAGCTGCAGGA
  CATCTGCGCTGGAGCCGGCAGTGTTGCGGATGAACCCTCCGGGCCTTGCGCACGGACATT
  A
• Restriction Sites: ECoRI-NOT
• ACCN: NM_001077191
• ORF Size: 993 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001077191.1, NP_001070659.1
• RefSeq Size: 2023
• RefSeq ORF: 993
• Locus ID: 151306
• Protein Families: Druggable Genome
• Gene Summary: This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.