SIVA (SIVA1) (NM_021709) Human Untagged Clone

CAT#: SC323987

SIVA1 (untagged)-Human SIVA1, apoptosis-inducing factor (SIVA1), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SIVA1
• Synonyms: CD27BP; SIVA; Siva-1; Siva-2
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_021709.2 GGGCTGGCGGCCGGGGAGCTGCGTAGCTCCCGGCCCCGCGGCCATGCCCAAGCGGAGCTG
  CCCCTTCGCGGACGTGGCCCCGCTACAGCTCAAGGTCCGCGTGAGCCAGAGGGAGTTGAG
  CCGCGGCGTGTGCGCCGAGCGCTACTCGCAGGAGGTCTTCGACCCATCTGGGGTAGCGTC
  CATTGCCTGTTCCTCATGCGTGCGAGCCGTGGATGGGAAGGCGGTCTGCGGTCAGTGTGA
  GCGAGCCCTGTGCGGGCAGTGTGTGCGCACCTGCTGGGGCTGCGGCTCCGTGGCCTGTAC
  CCTGTGTGGCCTCGTGGACTGCAGTGACATGTACGAGAAAGTGCTGTGCACCAGCTGTGC
  CATGTTCGAGACCTGAGGCTGGCTCAAGCCGGCTGCCTTCACCGGGAGCCACGCCGTGCA
  TGGCAGCCTTCCCTGGACGAGCGCTCGGTGTTCACACTGAACTGTGGGGTCGACGGGAGG
  GGTGCCTTTTACATGTTCTATTTTGTATCCTAATGACAGAATGAATAAACCTCTTTATAT
  TTGCACAAGAAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_021709.2 unedited
  TACAATTGTATACGACTCCTATAGGGCGGCCGGCGATCGCGGCGCGCCGGTACCGGTCCG
  GAATTCCCGGGATATCGTCGACCCACGCGTCCGGGGCTGGCGGCCGGGGAGCTGCGTAGC
  TCCCGGCCCCGCGGCCATGCCCAAGCGGAGCTGCCCCTTCGCGGACGTGGCCCCGCTACA
  GCTCAAGGTCCGCGTGAGCCAGAGGGAGTTGAGCCGCGGCGTGTGCGCCGAGCGCTACTC
  GCAGGAGGTCTTCGACCCATCTGGGGTAGCGTCCATTGCCTGTTCCTCATGCGTGCGAGC
  CGTGGATGGGAAGGCGGTCTGCGGTCAGTGTGAGCGAGCCCTGTGCGGGCAGTGTGTGCG
  CACCTGCTGGGGCTGCGGCTCCGTGGCCTGTACCCTGTGTGGCCTCGTGGACTGCAGTGA
  CATGTACGAGAAAGTGCTGTGCACCAGCTGTGCCATGTTCGAGACCTGAGGCTGGCTCAA
  GCCGGCTGCCTTCACCGGGAGCCACGCCGTGCATGGCAGCCTTCCCTGGACGAGCGCTCG
  GTGTTCACACTGAACTGTGGGGTCGACGGGAGGGGTGCCTTTTACATGTTCTATTTTGTA
  TCCTAATGACAGAATGAATAAACCTCTTTATATTTGCACAAGACAAAAAAAAAAAAAAAA
  AAAAGGGCGGCCGCACTCGAGGTTTAACGGCCGGCCCGCGGTCATAGCTGTTTCCTGAAC
  AGATCCCGGGTGGCATCCCTGTGACCCCTTCCCCAGTGCCTCTCCTGCCCTGGAAGTTGC
  CACTCCAGTGCCCACAGCCTTGTCCTAATAAAATTAGTTGCATCATTTTGTCTGACTAGG
  TGTCTCATACATTATCGGGTGCAGGGGATGATGCACCATGACACTAGTAATCACCGTTAG
  CGCTTGATGATGCATTGTGCACTGACGTTGAGTCGC
• Restriction Sites: ECoRI-NOT
• ACCN: NM_021709
• ORF Size: 333 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_021709.2, NP_068355.1
• RefSeq Size: 595
• RefSeq ORF: 333
• Locus ID: 10572
• Protein Families: Druggable Genome
• Gene Summary: This gene encodes an E3 ubiquitin ligase that regulates cell cycle progression, cell proliferation and apoptosis. The N-terminus of this protein binds to the cytoplasmic tail of the CD27 antigen, a member of the tumor necrosis factor receptor (TNFR) superfamily. In response to UV radiation-induced DNA damage, this protein has been shown to mediate the ubiquitination of proliferating cell nuclear antigen (PCNA), an important step in translesion DNA synthesis. [provided by RefSeq, Sep 2018]
  Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1. It appears to lack the apoptotic properties of Siva. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.