POFUT2 (NM_133635) Human Untagged Clone

CAT#: SC324043

POFUT2 (untagged)-Human protein O-fucosyltransferase 2 (POFUT2), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: POFUT2
• Synonyms: C21orf80; FUT13
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_133635.4 CGGGGCCATGGCGACACTCAGCTTCGTCTTCCTGCTGCTGGGGGCAGTGTCCTGGCCTCC
  GGCTTCTGCCTCCGGCCAGGAGTTCTGGCCCGGACAATCGGCGGCCGATATTCTGTCGGG
  GGCGGCTTCCCGCAGACGGTATCTTCTGTATGACGTCAACCCCCCGGAAGGCTTCAACCT
  GCGCAGGGATGTCTATATCCGAATCGCCTCTCTCCTGAAGACTCTGCTGAAGACGGAGGA
  GTGGGTGCTTGTCCTGCCTCCATGGGGCCGCCTCTATCACTGGCAGAGTCCTGACATCCA
  CCAGGTCCGGATTCCCTGGTCTGAGTTTTTTGATCTTCCAAGTCTCAATAAAAACATCCC
  CGTCATCGAGTATGAGCAGTTCATCGCAGAATCTGGTGGGCCCTTTATTGACCAGGTTTA
  CGTCCTGCAAAGTTACGCAGAGGGGTGGAAAGAAGGGACCTGGGAAGAGAAGGTGGACGA
  GCGGCCGTGTATTGATCAGCTCCTGTACTCCCAGGACAAGCACGAGTACTACAGAGGATG
  GTTTTGGGGTTATGAGGAGACCAGGGGTCTAAACGTCTCCTGTCTGTCCGTCCAGGGCTC
  AGCCTCCATCGTGGCGCCCCTGCTGCTGAGAAACACATCAGCCCGGTCCGTGATGTTAGA
  CAGAGCCGAGAACCTACTTCACGACCACTATGGAGGGAAAGAATACTGGGATACCCGTCG
  CAGCATGGTGTTTGCCAGGCACCTGCGGGAGGTGGGAGACGAGTTCAGGAGCAGACATCT
  CAACTCCACGGACGACGCAGACAGGATCCCCTTCCAGGAGGACTGGATGAAGATGAAGGT
  CAAGCTGGGCTCCGCGCTAGGGGGCCCCTACCTGGGAGTCCACCTGAGAAGAAAAGATTT
  CATCTGGGGTCACAGACAGGATGTACCCAGTCTGGAAGGGGCCGTGAGGAAGATCCGCAG
  CCTCATGAAGACCCACCGGCTGGACAAGGTGTTTGTGGCCACAGATGCCGTCAGAAAGGA
  ATATGAAGAGCTAAAAAAGCTGTTACCCGAGATGGTGAGGTTTGAACCCACGTGGGAGGA
  GCTGGAGCTCTACAAGGACGGAGGCGTTGCGATTATTGACCAGTGGATCTGCGCACACGC
  CAGGTTTTTTATTGGCACCTCAGTCTCAACATTTTCTTTTCGGATTCATGAGGAAAGAGA
  AATCCTGGGGTTGGACCCCAAGACGACGTACAACAGGTTCTGCGGAGACCAAGAGAAGGC
  GTGTGAGCAACCCACCCACTGGAAGATCACCTACTGAGGAGGATCCTCCAGGGCCGCTCC
  CCGGACCCGACAGGCGCGGGTGGATGCAGGTTCTGTCGCCGTGGAGTCACCGTCTACTGC
  CAGCCGGGAGCTGGGCGGACAGGACCGTCCCTCGCAGGGTCCCAGGCCCAGAAGAGGCCC
  CACGCCTCTAGAGCTGGGCTCCGTCCTCGGCGTTGCCAGCCGCCATGGCTGATGAAGAGG
  CTCCGCTGCTCTCGGGGGTGGCGGTTGTTTTCAGGCAGCGTCTGTGAACCCACAGCTCGG
  TTGCCAGCAGTGCCCGCGTGGTGACCCAGAAGCAGGAGTGTTTGTCAGGCTCCCGCTCTG
  GCCTTTCCAGCCACCTTTCATGTCTTCATATTTTAAGTGCATTGAGGATAGATGCAGGCG
  GGTGAGCTGCCCTCCGTCAGGTGGACCCGGGCTGACATTTCCCTGGGAGCTGGTGCAAGG
  AGAAGCGTCATTTTAAATGTCTGCAGAGCGACCAGGGGCCTCATGAATCTCTCCGTTGCC
  CTCCGCGCAGCAGGAGGCTGCCTGTGTGTTTCCTCCTGGGATGCGTGCAAGGCAGACCTG
  GTGCTGCAAAGGAAAGGGCCTGAGGCCTCAGGGAGCCCCGTGGAGGGATGACAGTTCAGG
  CCCTACTGCTGGCACGTCAGAGCACTGGGAAGTTTTTCAGTGACGTCTCTGGGGCACTCA
  GTGGATTGTCTGTAGGAAACTTGCAGCTCTGCTCCTCACACCAGGCCCGGCTGGCCACCC
  ACCCTCGCCCCCACTGGCCACCCCTCCCTCGCCCCGACTGCCCCGCCCCACCCTCACCCC
  GACTGCCCCGCCCTCGCCCGGCTGGCCGTCCCTGCCCTCGCCCCGGCTGGCAGGTGCACA
  TGGGGCCTCCAGGTCTGCCATTCGCTATTGAGAACTAGAAATGAGGAAGGACAGTTACGC
  TAACTCCAAAAGGCTGTCTAGGATGAGCTGCTTTATCAGGGAGCTCCTTGTACCCATTTT
  ACAGAAATCATTTTTAGGTCTTTGTGCCACCACCACGAGGGGCATCTGCAAAGAGGGCAA
  CGCTAGACACAGAATCCGTGGAAGGTGCAGCAGTGCCTCAGGGGTCCTCAGGGTCAGGGA
  GCCCCCCTCACCCTCTTGGCCCGTTACCCTTTGTGACTTTCCACCATGGTGTCGTGTGAC
  CCTCAGTCAGGTTGGTGGGGGCTGAGTCCTCACTGAGCAGCCACTTTCCACATCTGCTAG
  AGGAACAGTGACATGGACACCTGTGACAGAGAGAGGACAGTTAGGAGGGACAGACAGCTC
  TTCCTTTCGGAGCCTGGCTAGTCTAGGACATCACCTTGCTGTGTCTTCTCAAGCTTTTAA
  AATTGACCCTGAACGTGTGACAGGGTCCTATGGTGTTACTCAAAGCTGTGCAGGGTAAAT
  GATGACATATTTATTCTTTTTCCATTTGTTCTAGAAACAGTGCCTTTTTCATCAGTTGCA
  TTTTCCAGGCTGAGAGCTGTATAAAACATTTTGGACTGTGACCATGTACCTTCCTTTTTA
  AGAAAAATAAACTGCTTTATGGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  AAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_133635.4 unedited
  GGCCTTTGTATACGACTCCTATAGGGCGGCCGGCGATCGCGGCGCGCCGGTACCGGTCCG
  GAATTCCCGGGATCGGGGCCATGGCGACACTCAGCTTCGTCTTCCTGCTGCTGGGGGCAG
  TGTCCTGGCCTCCGGCTTCTGCCTCCGGCCAGGAGTTCTGGCCCGGACAATCGGCGGCCG
  ATATTCTGTCGGGGGCGGCTTCCCGCAGACGGTATCTTCTGTATGACGTCAACCCCCCGG
  AAGGCTTCAACCTGCGCAGGGATGTCTATATCCGAATCGCCTCTCTCCTGAAGACTCTGC
  TGAAGACGGAGGAGTGGGTGCTTGTCCTGCCTCCATGGGGCCGCCTCTATCACTGGCAGA
  GTCCTGACATCCACCAGGTCCGGATTCCCTGGTCTGAGTTTTTTGATCTTCCAAGTCTCA
  ATAAAAACATCCCCGTCATCGAGTATGAGCAGTTCATCGCAGAATCTGGTGGGCCCTTTA
  TTGACCAGGTTTACGTCCTGCAAAGTTACGCAGAGGGGTGGAAAGAAGGGACCTGGGAAG
  AGAAGGTGGACGAGCGGCCGTGTATTGATCAGCTCCTGTACTCCCAGGACAAGCACGAGT
  ACTACAGAGGATGGTTTTGGGGTTATGAGGAGACCAGGGGTCTAAACGTCTCCTGTCTGT
  CCGTCCAGGGCTCAGCCTCCATCGTGGCGCCCCTGCTGCTGAGAAACACATCAGCCCGGT
  CCGTGATGTTAGACAGAGCCGAGAACCTACTTCACGACCACTATGGAGGGAAAGAATACT
  GGGATACCCGTCGCAGCATGTGTTTGCCAGGCACCTGCGGAGGTGGGAGACGAGTTCAGG
  AGCAGAAATCTCACTCCACCGGACGACGCAGACGGATCCCTTCAGGAGACTGATGAAGAT
  GAAGGTCAAGCTGGCTCCGGCCCTTAGGGGCGCCCCTACCCTGGGAGTCCACTCGTGAA
• Restriction Sites: ECoRI-NOT
• ACCN: NM_133635
• ORF Size: 1290 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_133635.4, NP_598368.2
• RefSeq Size: 2878
• RefSeq ORF: 1290
• Locus ID: 23275
• Gene Summary: Fucose is typically found as a terminal modification of branched chain glycoconjugates, but it also exists in direct O-linkage to serine or threonine residues within cystine knot motifs in epidermal growth factor (EGF; MIM 131530)-like repeats or thrombospondin (THBS; see MIM 188060) type-1 repeats. POFUT2 is an O-fucosyltransferase that use THBS type-1 repeats as substrates (Luo et al., 2006 [PubMed 16464857]). [supplied by OMIM, Mar 2008]
  Transcript Variant: This variant (3) differs in the 3' UTR and coding region compared to variant 1. The resulting isoform (C) is longer and differs in the C-terminus compared to isoform A.