RAD17 (NM_002873) Human Untagged Clone

CAT#: SC324090

RAD17 (untagged)-Human RAD17 homolog (S. pombe) (RAD17), transcript variant 8


  "NM_002873" in other vectors (7)

Reconstitution Protocol

USD 760.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol RAD17
Synonyms CCYC; HRAD17; R24L; RAD17SP; RAD24
Vector pCMV6-AC
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
>OriGene sequence for NM_002873.1 TTGCTGTCGAAAGTTTTACTATAATGAAAGATATTTTCATACTCTCAAAAATATAGAGGA
AAGGGGCCAAGATTATAGTACCAGTCACAATCTTTTGATGAGGACGAAATGAATCAGGTA
ACAGACTGGGTTGACCCATCATTTGATGATTTTCTAGAGTGTAGTGGCGTCTCTACTATT
ACTGCCACATCATTAGGTGTGAATAACTCAAGTCATAGAAGAAAAAATGGGCCTTCTACA
TTAGAAAGCAGCAGATTTCCAGCGAGAAAAAGAGGAAATCTATCTTCCTTAGAACAGATT
TATGGTTTAGAAAATTCAAAAGAATATCTGTCTGAAAATGAACCATGGGTGGATAAATAT
AAACCAGAAACTCAGCATGAACTTGCTGTGCATAAAAAGAAAATTGAAGAAGTCGAAACC
TGGTTAAAAGCTCAAGTTTTAGAAAGGCAACCAAAACAGGGTGGATCTATTTTATTAATA
ACAGGTCCTCCTGGATGTGGAAAGACAACGACCTTAAAAATACTATCAAAGGAGCATGGT
ATTCAAGTACAAGAGTGGATTAATCCAGTTTTACCAGACTTCCAAAAAGATGATTTCAAG
GGGATGTTTAATACTGAATCAAGCTTCCATATGTTTCCCTATCAGTCTCAGATAGCAGTT
TTCAAAGAGTTTCTACTAAGAGCGACAAAGTATAACAAGTTACAAATGCTTGGAGATGAT
CTGAGAACTGATAAGAAGATAATTCTGGTTGAAGATTTACCTAACCAGTTTTATCGGGAT
TCTCATACTTTACATGAAGTTCTAAGGAAGTATGTGAGGATTGGTCGATGTCCTCTTATA
TTTATAATCTCGGACAGTCTCAGTGGAGATAATAATCAAAGGTTATTGTTTCCCAAAGAA
ATTCAGGAAGAGTGTTCTATCTCAAATATTAGTTTCAACCCTGTGGCACCAACAATTATG
ATGAAATTTCTTAATCGAATAGTGACTATAGAAGCTAACAAGAATGGAGGAAAAATTACT
GTCCCTGACAAAACTTCTCTAGAGTTGCTCTGTCAGGGATGTTCTGGTGATATCAGAAGT
GCAATAAACAGCCTCCAGTTTTCTTCTTCAAAAGGAGAAAACAACTTACGGCCAAGGAAA
AAAGGAATGTCTTTAAAATCAGATGCTGTGCTGTCAAAATCAAAACGAAGAAAAAAACCT
GATAGGGTTTTTGAAAATCAAGAGGTCCAAGCTATTGGTGGCAAAGATGTTTCTCTGTTT
CTCTTCAGAGCTTTGGGGAAAATTCTATATTGTAAAAGAGCATCTTTAACAGAATTAGAC
TCACCTCGGTTGCCCTCTCATTTATCAGAATATGAACGGGATACATTACTTGTTGAACCT
GAGGAGGTAGTAGAAATGTCACACATGCCTGGAGACTTATTTAATTTATATCTTCACCAA
AACTACATAGATTTCTTCATGGAAATTGATGATATTGTGAGAGCCAGTGAATTTCTGAGT
TTTGCAGATATCCTCAGTGGTGACTGGAATACACGCTCTTTACTCAGGGAATATAGCACA
TCTATAGCTACGAGAGGTGTGATGCATTCCAACAAAGCCCGAGGATATGCTCATTGCCAA
GGAGGAGGATCAAGTTTTCGACCCTTGCACAAACCTCAGTGGTTTCTAATAAATAAAAAG
TATCGGGAAAATTGCCTGGCAGCAAAAGCACTTTTTCCTGACTTCTGCCTACCAGCTTTA
TGCCGCCAAACTCAGCTATTGCCATACCTTGCTCTACTAACCATTCCAATGAGAAATCAA
GCTCAGATTTCTTTTATCCAAGATATTGGAAGGCTCCCTCTGAAGCGACACTTTGGAAGA
TTGAAAATGGAAGCCCTGACTGACAGGGAACATGGAATGATAGACCCTGACAGCGGAGAT
GAAGCCCAGCTTAATGGAGGACATTCTGCAGAGGAATCTCTGGGTGAACCCACTCAAGCC
ACTGTGCCGGAAACCTGGTCTCTTCCTTTGAGTCAGAATAGTGCCAGTGAACTGCCTGCT
AGCCAGCCCCAGCCCTTTTCAGCCCAAGGAGACATGGAAGAAAACATAATAATAGAAGAC
TACGAGAGTGATGGGACATAGAAGCCAGCCTGCTAATCAGATTGCTACTTCACAGCTTCA
TTTTTGTTTCATTCAGTGGTACTTCAGCAGAGTTAATATGCTTTTCTGATGAATTACACA
ACAGTTTGTTAATTCTTCATTCTTGTAGTATTTCATCACAAGAAACCTACTCTTCTGTCA
TCTTGAAGTAAATAGAAGATCAAGCCTTCAAATCTCTTAATTTTTTCGGTATTTATTAAA
TCTGTGAGTGGTTTAAGGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAA
Restriction Sites ECoRI-NOT     
ACCN NM_002873
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_002873.1, NP_002864.1
RefSeq Size 3164 bp
RefSeq ORF 2013 bp
Locus ID 5884
Cytogenetics 5q13.2
Domains Rad17
Protein Families Druggable Genome
Gene Summary 'The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013]'
Transcript Variant: This variant (8) has an alternate 5' terminal sequence and lacks an internal exon in the 5' UTR, when compared to variant 1. The encoded protein (isoform 1) is identical to that encoded by variants 1, 5, 6, 7 and 9.

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