TIRAP (NM_001039661) Human Untagged Clone

CAT#: SC324197

TIRAP (untagged)-Human toll-interleukin 1 receptor (TIR) domain containing adaptor protein (TIRAP), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TIRAP
• Synonyms: BACTS1; Mal; MyD88-2; wyatt
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_001039661.1 CCGCGCAGCCCTCATCGCAACTGGGCCCGCGCGCAGATCCACCAAAGAGAAAGCAGCCCT
  GTGCCAGTTGCTCTGCCAGCCTTTCACAGGAGAAGTGTCACTAGAATACTACAGCCCCCA
  CAGGCTCTGCTCCACAGAAACTTAAGGCTGAAAGAGTGTCCGCCATCAGGGACATCCTCT
  GTCACTACGGCCTTACATAGGAAGTCCTTCTAAAGAGCTGCCTGCCAGCTGCCCTTCCCC
  AGATCCCGAATATCCTCCTGGCCAGGTGGAGCAGAGAACAGTTCCTCAGCTGGTCATGCT
  GAGCTCATACCCTGATGGCTGCTCCATGAGGTCAAGACTGGGTCTCCTCCCTCCTCCCCC
  TTCACCAATGCCTGGTCTCACGGGGCTAGTTTTGACCCCCACGCTATGGCATCATCGACC
  TCCCTCCCAGCTCCTGGCTCTCGGCCTAAGAAGCCTCTAGGCAAGATGGCTGACTGGTTC
  AGGCAGACCCTGCTGAAGAAGCCCAAGAAGAGGCCCAACTCCCCAGAAAGCACCTCCAGC
  GATGCTTCACAGCCTACCTCACAGGACAGCCCACTACCCCCAAGCCTCAGCTCAGTCACG
  TCTCCCAGCCTGCCACCCACACATGCGAGTGACAGTGGCAGTAGTCGCTGGAGCAAAGAC
  TATGACGTCTGCGTGTGCCACAGTGAGGAAGACCTGGTGGCCGCCCAGGACCTGGTCTCC
  TACTTGGAAGGCAGCACTGCCAGCCTGCGCTGCTTCCTGCAACTCCGGGATGCAACCCCA
  GGCGGCGCTATAGTGTCCGAGCTGTGCCAGGCACTGAGCAGTAGTCACTGCCGGGTGCTG
  CTCATCACGCCGGGCTTCCTTCAGGACCCCTGGTGCAAGTACCAGATGCTGCAGGCCCTG
  ACCGAGGCTCCAGGGGCCGAGGGCTGCACCATCCCCCTGCTGTCGGGCCTCAGCAGAGCT
  GCCTACCCACCTGAGCTCCGATTCATGTACTACGTCGATGGCAGGGGCCCTGATGGTGGC
  TTTCGTCAAGTCAAAGAAGCTGTCATGCGTTATCTGCAGACACTCAGTTGGCACTTGTTA
  TATCATGGGACCCCGGAAATTGGAGTGAAGCTAGAAACAGAAAACCCATGCAGGGCCTCG
  GATTCCCACAAATGTGACAAGAGGTATAGGGAGTGAGTCGCAGCGCTTTGCTCGTGACCC
  TGGGATCAGAGCACCCATCAGGCTTCCATTACTGTGGGCTCCCTAAGAAGACCATGGAGA
  GCTTGGGGACTCCCCCAGGAAGGCCGTGAAGCTGGGGATTCCCCCTAGGAAAGCCATGAG
  GAAGCTGGGGACTCCCCAAGAAGGCCATGAGGAAGCCAGAAATTGGAGGTGGTAGGAAGT
  GGTACTGATCAATGATGGCCAGCAGGACTCATCTCCTGCCTAACTGGACAGGAAGCCTGG
  CACCCACTTCTGTCTTCCCCTGGAACTGGGCACTGGCGTACACTGGTATCCCTCCTAAAG
  AAGTGACTCACCTGACTGATCAGCAAGAAGCCTAGATTGCAGGCCTCACCATGGATGGTC
  TTCCTAGTTGCCTGGGGAAACCCTGGAATGGGCATCAGGAGAAAGCAACAAGAATCCAGT
  CCTTCACACTCACACTACTCTGTTCCTCTTCCCAGAGACATCGATTCACTTCAAAGAGCT
  GTAGGGAAGATGCAGTCAGCACTGCACTGTATTTTTTATTTATTGCCTAGGTGCCATTAA
  AGACACAAACCTAGAAGCCTAGAGGCCATTCTGAATATGGGGGTGGGGTGGTGGAGGGAG
  CAAGTGAAGAGATGGGAATCCAGGGCTCAGGGTTCAACGCCTTCACCTGAGATCACAAGC
  CCATGGATGCTGTGACATCTGGGAGCTTCATCAGTGGTCTGGCTAAAGCTGATACTTTCA
  CAGTCACCATCTTCACCTTTGGACTGGGAAGAATCACCATTTTTCTTCTGGCAGATGACT
  GTATTCCTTATAGGACAGGCAAGGTTTCATTCATCTGTTCTCAGTAAGTTTGTTGTTGAA
  CTGAAATGAATTTCATTATTTCCTCCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_001039661.1 unedited
  CGGGACAGAGGGAAAGCGGAACAAAAAGGAAGGTGAGGGAACGCGGCGGCAGGTCCGGAC
  CAGAAAACCAGGGATCCGCGCAGCCCTCATCGCAACTGGGCCCGCGCGCAGATCCACCAA
  AGAGAAAGCAGCCCTGTGCCAGTTGCTCTGCCAGCCTTTCACAGGAGAAGTGTCACTAGA
  ATACTACAGCCCCCACAGGCTCTGCTCCACAGAAACTTAAGGCTGAAAGAGTGTCCGCCA
  TCAGGGACATCCTCTGTCACTACGGCCTTACATAGGAAGTCCTTCTAAAGAGCTGCCTGC
  CAGCTGCCCTTCCCCAGATCCCGAATATCCTCCTGGCCAGGTGGAGCAGAGAACAGTTCC
  TCAGCTGGTCATGCTGAGCTCATACCCTGATGGCTGCTCCATGAGGTCAAGACTGGGTCT
  CCTCCCTCCTCCCCCTTCACCAATGCCTGGTCTCACGGGGCTAGTTTTGACCCCCACGCT
  ATGGCATCATCGACCTCCCTCCCAGCTCCTGGCTCTCGGCCTAAGAAGCCTCTAGGCAAG
  ATGGCTGACTGGTTCAGGCAGACCCTGCTGAAGAAGCCCAAGAAGAGGCCCAACTCCCCA
  GAAAGCACCTCCAGCGATGCTTCACAGCCTACCTCACAGGACAGCCCACTACCCCCAAGC
  CTCAGCTCAGTCACGTCTCCCAGCCTGCCACCCACACATGCGAGTGACAGTGGCAGTAGT
  CGCTGGAGCAAGACTATGACGTCTGCGTGTGCCACAGTGAGGAAGACCTGGTGGCCGCCC
  AGGACCTGGTCTCCTACTTGGAAGGCAGCACTGCCAGCCTGCGCTGCTTCCTGCAACTTC
  CGGGATGCGACCCCAGCGGCGCTATAATGGTCAGATGCTGTGCCATGCACATGAACAGTA
  TTACATTGCCAGATGACGCTCACAGCTCGGACGTCCTGACGGAACAATGGTGTCCATGGA
  CAGTATGCTCGATATCCCATGACGC
• Restriction Sites: ECoRI-NOT
• ACCN: NM_001039661
• ORF Size: 666 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001039661.1, NP_001034750.1
• RefSeq Size: 2348
• RefSeq ORF: 666
• Locus ID: 114609
• Protein Families: Druggable Genome
• Protein Pathways: Toll-like receptor signaling pathway
• Gene Summary: The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (3) represents the longer transcript but encodes the shorter isoform (a). Variants 3 and 5 both encode the same isoform (a).