Beclin 1 (BECN1) (NM_003766) Human Untagged Clone

CAT#: SC324265

BECN1 (untagged)-Human beclin 1, autophagy related (BECN1)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: BECN1
• Synonyms: ATG6; beclin1; VPS30
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_003766.2 GCTGAAGACAGAGCGATGGTAGTTCTGGAGGCCTCGCTCCGGGGCCGACCCGAGGCCACA
  GTGCCTCCGCGGTAGACCGGACTTGGGTGACGGGCTCCGGGCTCCCGAGGTGAAGAGCAT
  CGGGGGCTGAGGGATGGAAGGGTCTAAGACGTCCAACAACAGCACCATGCAGGTGAGCTT
  CGTGTGCCAGCGCTGCAGCCAGCCCCTGAAACTGGACACGAGTTTCAAGATCCTGGACCG
  TGTCACCATCCAGGAACTCACAGCTCCATTACTTACCACAGCCCAGGCGAAACCAGGAGA
  GACCCAGGAGGAAGAGACTAACTCAGGAGAGGAGCCATTTATTGAAACTCCTCGCCAGGA
  TGGTGTCTCTCGCAGATTCATCCCCCCAGCCAGGATGATGTCCACAGAAAGTGCCAACAG
  CTTCACTCTGATTGGGGAGGCATCTGATGGCGGCACCATGGAGAACCTCAGCCGAAGACT
  GAAGGTCACTGGGGACCTTTTTGACATCATGTCGGGCCAGACAGATGTGGATCACCCACT
  CTGTGAGGAATGCACAGATACTCTTTTAGACCAGCTGGACACTCAGCTCAACGTCACTGA
  AAATGAGTGTCAGAACTACAAACGCTGTTTGGAGATCTTAGAGCAAATGAATGAGGATGA
  CAGTGAACAGTTACAGATGGAGCTAAAGGAGCTGGCACTAGAGGAGGAGAGGCTGATCCA
  GGAGCTGGAAGACGTGGAAAAGAACCGCAAGATAGTGGCAGAAAATCTCGAGAAGGTCCA
  GGCTGAGGCTGAGAGACTGGATCAGGAGGAAGCTCAGTATCAGAGAGAATACAGTGAATT
  TAAACGACAGCAGCTGGAGCTGGATGATGAGCTGAAGAGTGTTGAAAACCAGATGCGTTA
  TGCCCAGACGCAGCTGGATAAGCTGAAGAAAACCAACGTCTTTAATGCAACCTTCCACAT
  CTGGCACAGTGGACAGTTTGGCACAATCAATAACTTCAGGCTGGGTCGCCTGCCCAGTGT
  TCCCGTGGAATGGAATGAGATTAATGCTGCTTGGGGCCAGACTGTGTTGCTGCTCCATGC
  TCTGGCCAATAAGATGGGTCTGAAATTTCAGAGATACCGACTTGTTCCTTACGGAAACCA
  TTCATATCTGGAGTCTCTGACAGACAAATCTAAGGAGCTGCCGTTATACTGTTCTGGGGG
  GTTGCGGTTTTTCTGGGACAACAAGTTTGACCATGCAATGGTGGCTTTCCTGGACTGTGT
  GCAGCAGTTCAAAGAAGAGGTTGAGAAAGGCGAGACACGTTTTTGTCTTCCCTACAGGAT
  GGATGTGGAGAAAGGCAAGATTGAAGACACAGGAGGCAGTGGCGGCTCCTATTCCATCAA
  AACCCAGTTTAACTCTGAGGAGCAGTGGACAAAAGCTCTCAAGTTCATGCTGACGAATCT
  TAAGTGGGGTCTTGCTTGGGTGTCCTCACAATTTTATAACAAATGACTTTTTTCCTTAGG
  GGGAGGTTTGCCTTAAAGGCTTTTAATTTTGTTTTGTTTGCAAACATGTTTTAAATTAAA
  TTCGGGTAATATTAAACAGTACATGTTTACAATACCAAAAAAGAAAAAATCCACAAAAGC
  CACTTTATTTTAAAATATCATGTGACAGATACTTTCCAGAGCTACAACATGCCATCTATA
  GTTGCCAGCCCTGGTCAGTTTTGATTCTTAACCCCATGGACTCCTTTCCCTTTCTTCTCT
  GAAAAAAACTAATTTAAATTTGCTTTTCTTTTTTTTAACTGAGTTGAATTGAGATTGATG
  TGTTTTCACTGGATTTTTATCTCTCTCAACTTCCTGCACTTAACAATATGAAATAGAAAC
  TTTTGTCTTTACTGAGATGAGGATATGTTTGAGATGCACAGTTGGATAATGTGGGAAAAT
  GACATCTAAGCTTTACCTGGTCACCATGTGATGTGATCAGATGCTTGAAATTTAACACTT
  TTCACTTGGTTCTTATACTGAATGCCGACTCTGCTCTGTGTTAGAGATATGAAATGGTGT
  TTGATACTGTTTGAGACATTATGGAGAGATTTAATTATTTGTAATAAAAGATTTGCTGCA
  GTCTGAAAACTGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003766.2 unedited
  TGCTACCCCTGTAAGCCTCCCGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCA
  GCCTCCGGACTCTAGCCTAGGCCGCGGGACGGATAACAATTTCACACAGGAAACAGCTAT
  GACCATTAGGCCTATTTAGGTGACACTATAGAACAAGTTTGTACAAAAAAGCAGGCTGGT
  ACCGGTCCGGAATTCCCGGGATATCGTCGACCCACGCGTCCGGCTGAAGACAGAGCGATG
  GTAGTTCTGGAGGCCTCGCTCCGGGGCCGACCCGAGGCCACAGTGCCTCCGCGGTAGACC
  GGACTTGGGTGACGGGCTCCGGGCTCCCGAGGTGAAGAGCATCGGGGGCTGAGGGATGGA
  AGGGTCTAAGACGTCCAACAACAGCACCATGCAGGTGAGCTTCGTGTGCCAGCGCTGCAG
  CCAGCCCCTGAAACTGGACACGAGTTTCAAGATCCTGGACCGTGTCACCATCCAGGAACT
  CACAGCTCCATTACTTACCACAGCCCAGGCGAAACCAGGAGAGACCCAGGAGGAAGAGAC
  TAACTCAGGAGAGGAGCCATTTATTGAAACTCCTCGCCAGGATGGTGTCTCTCGCAGATT
  CATCCCCCAGCCAGGATGATGTCCACAGAAAGTGCCAACAGCTTCACTCTGATTGGGGAG
  GCATCTGATGGCGGCACCATGGAGAACCTCAGCCGAAGACTGAAAGGTCACTGGGGACCT
  TTTTGACATCATGTCGGGCCAGACAGATGTGGATCACCCACTCTGTGAGGAATGCACAGA
  TACTCTTTTAGACCAGCTGACACTCAGCTCACGTCACTGAAAATGATGTCAGACTACAAC
  GCTGTTTGAGATCTTAGAGCAATGATGAGATGACAGTGACAGTTACAGATGAGCTAAGGG
  CTGCACTAGAGAGAAAGCTGATCCAGGGCTGCGAACGTGGCAAAGAACCCGCAGATTGTG
  GGCGAAT
• Restriction Sites: Please inquire
• ACCN: NM_003766
• ORF Size: 1353 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_003766.2, NP_003757.1
• RefSeq Size: 2144
• RefSeq ORF: 1353
• Locus ID: 8678
• Domains: APG6
• Protein Families: Druggable Genome
• Protein Pathways: Regulation of autophagy
• Gene Summary: This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
  Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1 and 2 encode the same isoform.