Apc2 (ANAPC2) (NM_013366) Human Untagged Clone

CAT#: SC324311

ANAPC2 (untagged)-Human anaphase promoting complex subunit 2 (ANAPC2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ANAPC2
• Synonyms: APC2
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_013366.3 TGCAGATGGCGGCGGCAGTTGTGGTGGCGGAGGGGGACAGCGACTCCCGGCCCGGACAGG
  AGTTGTTAGTGGCCTGGAACACCGTGAGCACCGGCCTGGTGCCGCCGGCTGCGCTGGGGC
  TGGTGTCTTCCCGGACCAGCGGTGCAGTCCCGCCAAAGGAAGAGGAGCTCCGGGCGGCGG
  TGGAGGTTCTGAGGGGCCACGGGCTACACTCGGTCCTGGAGGAGTGGTTCGTGGAGGTGC
  TGCAGAACGATCTGCAGGCCAACATCTCCCCTGAGTTCTGGAATGCCATCTCCCAATGCG
  AGAACTCTGCGGATGAGCCCCAGTGCCTTTTGCTACTCCTTGACGCTTTTGGCCTGCTGG
  AGAGCCGCCTGGATCCCTACCTGCGTAGCCTAGAGCTGCTGGAGAAATGGACTCGCCTGG
  GCTTGCTGATGGGCACTGGTGCTCAGGGGCTGCGAGAAGAAGTCCACACTATGTTGCGCG
  GAGTCTTGTTCTTTAGCACCCCCAGAACCTTCCAAGAGATGATCCAGCGTCTGTATGGGT
  GCTTCTTGAGAGTCTATATGCAGAGTAAGAGGAAGGGGGAAGGGGGCACAGACCCGGAAC
  TGGAAGGGGAGCTGGACAGCCGGTATGCCCGTCGCCGGTACTACCGGCTCCTGCAGAGCC
  CGCTGTGTGCAGGGTGCAGCAGTGACAAGCAACAGTGCTGGTGTCGCCAGGCTCTGGAGC
  AGTTCCATCAGCTCAGCCAGGTCTTACACAGGCTCAGTCTGCTGGAGCGGGTCAGTGCCG
  AGGCTGTGACCACCACCCTGCACCAGGTGACCCGGGAGAGGATGGAGGACCGTTGCCGGG
  GCGAGTACGAGCGCTCCTTCCTGCGTGAGTTCCACAAGTGGATCGAGCGGGTGGTCGGCT
  GGCTCGGCAAGGTGTTCCTGCAGGACGGCCCCGCCAGGCCCGCATCTCCCGAGGCCGGCA
  ACACCCTGCGCCGCTGGCGCTGCCACGTGCAAAGGTTCTTCTACCGCATCTACGCCAGCC
  TGCGCATCGAGGAGCTCTTCAGCATCGTCCGAGACTTCCCAGACTCCCGGCCAGCCATCG
  AGGACCTCAAGTACTGCCTGGAGAGGACGGACCAGAGGCAGCAGCTGCTCGTGTCCCTCA
  AGGCTGCCCTGGAGACTCGGCTCCTGCATCCAGGCGTCAACACGTGTGACATCATCACCC
  TCTATATCTCTGCCATCAAGGCGCTGCGCGTGCTGGACCCTTCCATGGTCATCCTGGAGG
  TGGCCTGTGAGCCTATCCGCCGCTACCTGAGGACGCGGGAGGACACAGTGCGGCAGATTG
  TGGCTGGGCTGACGGGGGACTCGGACGGGACAGGGGACCTGGCTGTTGAGCTGTCCAAGA
  CCGACCCGGCGAGCCTGGAGACAGGCCAGGACAGTGAGGATGACTCAGGCGAGCCAGAGG
  ACTGGGTCCCGGACCCTGTGGATGCCGATCCAGGGAAGTCGAGCTCCAAGCGGCGTTCAT
  CGGACATCATCAGCCTGCTGGTCAGCATCTACGGCAGCAAGGACCTCTTCATCAATGAGT
  ACCGCTCGCTGCTGGCCGACCGCCTGCTGCACCAGTTCAGCTTCAGCCCCGAGCGGGAGA
  TCCGCAACGTGGAGCTGCTGAAGCTGCGCTTTGGCGAGGCCCCAATGCACTTCTGTGAAG
  TCATGCTGAAGGACATGGCGGACTCCCGCCGCATCAATGCCAACATCCGGGAGGAGGATG
  AGAAGCGGCCAGCAGAGGAGCAGCCACCGTTCGGGGTCTACGCTGTCATCCTGTCCAGTG
  AGTTCTGGCCGCCCTTCAAGGACGAGAAGCTGGAGGTCCCCGAGGATATCAGGGCAGCCC
  TGGAGGCTTACTGCAAGAAGTATGAGCAGCTCAAGGCCATGCGGACCCTCAGTTGGAAGC
  ACACCCTGGGCCTGGTGACCATGGACGTGGAGCTGGCCGACCGCACGCTGTCTGTGGCGG
  TCACCCCAGTACAGGCGGTGATCTTGCTGTATTTTCAGGACCAAGCCAGCTGGACCCTGG
  AGGAACTGAGCAAGGCGGTGAAGATGCCCGTGGCGCTGCTGCGGCGGCGGATGTCCGTGT
  GGCTGCAGCAGGGTGTGCTGCGTGAGGAGCCCCCCGGCACCTTCTCTGTCATTGAGGAGG
  AGCGGCCTCAGGACCGGGACAACATGGTGCTCATTGACAGTGACGACGAGAGCGACTCCG
  GCATGGCCTCCCAGGCCGACCAGAAGGAGGAGGAGCTGCTGCTCTTCTGGACGTACATCC
  AGGCCATGCTGACCAACCTGGAGAGCCTCTCACTGGATCGTATCTACAACATGCTCCGCA
  TGTTTGTGGTGACTGGGCCTGCACTGGCCGAGATTGACCTGCAGGAGCTGCAGGGCTACC
  TGCAGAAGAAGGTGCGGGACCAGCAGCTCGTCTACTCGGCCGGCGTCTACCGCCTGCCCA
  AGAACTGCAGCTGACACATCGCCCGCCCGCCCGCCCGCCCGCCAGGCGCTGCCCTGCAGG
  TGCTCTCGTCCTCCCGTGCCAGCCCCCGCCCGCCCGTGTCCCAGAATGCACTGCTGAGGA
  GCATGCCCACCCCCACCCCCGCAGTGTGCAGATTAAAGCAAGTCAGATCATCAAAAAAAA
  AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_013366.3 unedited
  GGCAATGCATGTGACGCCCTTCCCGCATGTCTTTGACCTCCATAGAAGACACCGGGACCG
  ACTCCAGCCTCCGGACTCTAGCCTAGGCCGCGGGACGGATAACAATCTCACACAGGAAAC
  AGCTATGACCATCAGGCCTATTTAGGTGACACTATAGAACAAGTTTGTACAAAAAAGCAG
  GCTGGTACCGGTCCGGAATTCCCGGGATTGCAGATGGCGGCGGCAGTTGTGGTGGCGGAG
  GGGGACAGCGACTCCCGGCCCGGACAGGAGTTGTTAGTGGCCTGGAACACCGTGAGCACC
  GGCCTGGTGCCGCCGGCTGCGCTGGGGCTGGTGTCTTCCCGGACCAGCGGTGCAGTCCCG
  CCAAAGGAAGAGGAGCTCCGGGCGGCGGTGGAGGTTCTGAGGGGCCACGGGCTACACTCG
  GTCCTGGAGGAGTGGTTCGTGGAGGTGCTGCAGAACGATCTGCAGGCCAACATCTCCCCT
  GAGTTCTGGAATGCCATCTCCCAATGCGAGAACTCTGCGGATGAGCCCCAGTGCCTTTTG
  CTACTCCTTGACGCTTTTGGCCTGCTGGAGAGCCGCCTGGATCCCTACCTGCGTAGCCTA
  GAGCTGCTGGAGAAATGGACTCGCCTGGGCTTGCTGATGGGCACTGGTGCTCAGGGGCTG
  CGAGAAGAAGTCCACACTATGTTGCGCGGAGTCTTGTTCTTTAGCACCCCCAGAACCTTC
  CAAGAGATGATCCAGCGTCTGTATGGGTGCTTCTTGAGAGTCTATTATGCAGAGTAGGAG
  GAAGGGGGAAAGGGGCACAGACCCGACTGGAGGGGAGCTGGACAGCCGGTTATGCCCGTC
  GCCGGTACTACCGGCTCCTGCAAAGCCCGCTGTGTGCAAGTGCAAGCAGTGACAGCAACC
  AGTGGCTGTGGTCGCCAGGCTTCTGGAGACAGTTCATCAGCTTAGCCGAGTCTTAACCAA
  GCTTCAGTCCTGCTGAGAGCAGGGTCATGTGCCAGG
• Restriction Sites: Please inquire
• ACCN: NM_013366
• ORF Size: 2469 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_013366.3, NP_037498.1
• RefSeq Size: 2733
• RefSeq ORF: 2469
• Locus ID: 29882
• Domains: CULLIN
• Protein Families: Druggable Genome
• Protein Pathways: Cell cycle, Oocyte meiosis, Progesterone-mediated oocyte maturation, Ubiquitin mediated proteolysis
• Gene Summary: A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq, Jul 2008]