AIF (AIFM1) (NM_145812) Human Untagged Clone

CAT#: SC324345

AIFM1 (untagged)-Human apoptosis-inducing factor, mitochondrion-associated, 1 (AIFM1), nuclear gene encoding mitochondrial protein, transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: AIFM1
• Synonyms: AIF; CMT2D; CMTX4; COWCK; COXPD6; DFNX5; NADMR; NAMSD; PDCD8
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_145812, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGTTCCGGTGTGGAGGCCTGGCGGCGGGTGCTTTGAAGCAGAAGCTGGTGCCCTTGGTGCGGACCGTGT
  GCGTCCGAAGCCCGAGGCAGAGGAACCGGCTCCCAGTTGTGCAGTCTCATCACCTAGGATCCCCTTCTAG
  ATCACTAGCATCTACAGGTGCTTCTGGGAAAGATGGCAGCAACCTAGTGTACTTCTTAATTGTAGGAGCA
  ACAGTCACTGGGGCAGGAGTTTATTATGCCTACAAGACTATGAAAGAGGATGAAAAAAGATACAATGAAA
  GAATTTCAGGGTTAGGGCTGACACCAGAACAGAAACAGAAAAAGGCCGCGTTATCTGCTTCAGAAGGAGA
  GGAAGTTCCTCAAGACAAGGCGCCAAGTCATGTTCCTTTCCTGCTAATTGGTGGAGGCACAGCTGCTTTT
  GCTGCAGCCAGATCCATCCGGGCTCGGGATCCTGGGGCCAGGGTACTGATTGTATCTGAAGATCCTGAGC
  TGCCGTACATGCGACCTCCTCTTTCAAAAGAACTGTGGTTTTCAGATGACCCAAATGTCACAAAGACACT
  GCGATTCAAACAGTGGAATGGAAAAGAGAGAAGCATATATTTCCAGCCACCTTCTTTCTATGTCTCTGCT
  CAGGACCTGCCTCATATTGAGAATGGTGGTGTGGCTGTCCTCACTGGGAAGAAGGTAGTACAGCTGGATG
  TGAGAGACAACATGGTGAAACTTAATGATGGCTCTCAAATAACCTATGAAAAGTGCTTGATTGCAACAGG
  AGGTACTCCAAGAAGTCTGTCTGCCATTGATAGGGCTGGAGCAGAGGTGAAGAGTAGAACAACGCTTTTC
  AGAAAGATTGGAGACTTTAGAAGCTTGGAGAAGATTTCACGGGAAGTCAAATCAATTACGATTATCGGTG
  GGGGCTTCCTTGGTAGCGAACTGGCCTGTGCTCTTGGCAGAAAGGCTCGAGCCTTGGGCACAGAAGTGAT
  TCAACTCTTCCCCGAGAAAGGAAATATGGGAAAGATCCTCCCCGAATACCTCAGCAACTGGACCATGGAA
  AAAGTCAGACGAGAGGGGGTTAAGGTGATGCCCAATGCTATTGTGCAATCCGTTGGAGTCAGCAGTGGCA
  AGTTACTTATCAAGCTGAAAGACGGCAGGAAGGTAGAAACTGACCACATAGTGGCAGCTGTGGGCCTGGA
  GCCCAATGTTGAGTTGGCCAAGACTGGTGGCCTGGAAATAGACTCAGATTTTGGTGGCTTCCGGGTAAAT
  GCAGAGCTACAAGCACGCTCTAACATCTGGGTGGCAGGAGATGCTGCATGCTTCTACGATATAAAGTTGG
  GAAGGAGGCGGGTAGAGCACCATGATCACGCTGTTGTGAGTGGAAGATTGGCTGGAGAAAATATGACTGG
  AGCTGCTAAGCCGTACTGGCATCAGTCAATGTTCTGGAGTGATTTGGGCCCCGATGTTGGCTATGAAGCT
  ATTGGTCTTGTGGACAGTAGTTTGCCCACAGTTGGTGTTTTTGCAAAAGCAACTGCACAAGACAACCCCA
  AATCTGCCACAGAGCAGTCAGGAACTGGTATCCGATCAGAGAGTGAGACAGAGTCCGAGGCCTCAGAAAT
  TACTATTCCTCCCAGCACCCCGGCAGTTCCACAGGCTCCCGTCCAGGGGGAGGACTACGGCAAAGGTGTC
  ATCTTCTACCTCAGGGACAAAGTGGTCGTGGGGATTGTGCTATGGAACATCTTTAACCGAATGCCAATAG
  CAAGGAAGATCATTAAGGACGGTGAGCAGCATGAAGATCTCAATGAAGTAGCCAAACTATTCAACATTCA
  TGAAGACTGA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_145812.1 unedited
  GGCTTAGCCTGTAAGCCTCCCGCTGTTTTGACCTCCATAGAAGACACCGGGACCGATCCA
  GCCTCCGGACTCTAGCCTAGGCCGCGGGACGGATAACAATTTCACACAGGAAACAGCTAT
  GACCATTAGGCCTATTTAGGTGACACTATAGAACAAGTTTGTACAAAAAAGCAGGCTGGT
  ACCGGTCCGGAATTCCCGGGATCCGGCTCTAGCAGGCCGGCTTCTCTGTCCAATGCCCAC
  CCGGAGCTGGGAGGAGGAGTCTGCGTAATGTGCGTGTGAAGAGACTGGGGGAGCTGGCCG
  GGGCTCACGGTGTTTGACCCGTCGGTCGTGCGTGAGAGGAAAGGGAAGGAGGAGGTCCCG
  AATAGCGGTCGCCGAAATGTTCCGGTGTGGAGGCCTGGCGGCGGGTGCTTTGAAGCAGAA
  GCTGGTGCCCTTGGTGCGGACCGTGTGCGTCCGAAGCCCGAGGCAGAGGAACCGGCTCCC
  AGTTGTGCAGTCTCATCACCTAGGATCCCCTTCTAGATCACTAGCATCTACAGGTGCTTC
  TGGGAAAGATGGCAGCAACCTAGTGTACTTCTTAATTGTAGGAGCAACAGTCACTGGGGC
  AGGAGTTTATTATGCCTACAAGACTATGAAAGAGGACGAAAAAAGATACAATGAAAGAAT
  TTCAGGGTTAGGGCTGACACCAGACAGAAACAGAAAAAGGCCGCGTTATCTGCTTCAGAG
  GAGAGGAAGTTCCTCAAGACAAGGCGCCAGTCATGTTCCTTTCCTGCTAATTGGTGGAGG
  CACAGCTGCTTTTGCTGCAGCCAGATCCATCCGGCTCGGGATCTGAGCCAGGGTACTGAT
  GTATCTGAGATCTGAACTGCCGTACATGGCGACCTCCTCTTTCCAAAAGACCTGTGGTTT
  CTCAAGTGAACCCATATGTTCACAA
• Restriction Sites: Please inquire
• ACCN: NM_145812
• ORF Size: 1830 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_145812.1, NP_665811.1
• RefSeq Size: 2203
• RefSeq ORF: 1830
• Locus ID: 9131
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Apoptosis
• Gene Summary: This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and cognitive disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. [provided by RefSeq, Aug 2015]
  Transcript Variant: This variant (2) lacks an alternate in-frame exon but contains a different in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (AIF-exB) that is shorter than isoform AIF.