Antizyme inhibitor 1 (AZIN1) (NM_015878) Human Untagged Clone

CAT#: SC324431

AZIN1 (untagged)-Human antizyme inhibitor 1 (AZIN1), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: AZIN1
• Synonyms: AZI; AZI1; AZIA1; OAZI; OAZIN; ODC1L
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_015878.4 CGCAGTTTTTCCTTTTTTCTTCTGCCGTCGCCTTCTCTGCCTCTTCTCATCCTTTCTCGC
  TCTGCTGCTCTGCAGTGTGACGAGTCCGAATCCTCTTCCCACCCAGCCCGCGCCTTTCTT
  CTTTTGCCTGCGCTGTTCTATTTCTCCTTCGGCCGCCGCCGCCACTGCTGCACACAGCTG
  GTGTCGGTGCCGCGCTTTTACCCCCAAGTCGTTCCCGCAGCCTATGGCCCAGGCCGCCTT
  GGGTATTTCTGCTCAAGGTAACCACATCCCTCTTTAAAAATTCCGCCGAAAAAGAGAAGA
  CGCTTTACCCGACTCTTTGGGCCGTTATCTCACGGCGAACTTTCTGACCAAGTATACAAC
  TACCCAGAGGGCCTAGGAGAAGTGCTGTATAGAGAGCAGTTCGACTTCAACGCTGAGCCA
  CCTTGGGAACCTAGCTGATGATAGGGGGGTTCCATCTCCCAACTTGTCCATGGAGGTCTT
  CACTTCAGAAATCCAAGACTCATATTCATCCAGCTTGGTGTCAAGTGGGCTGTTGCTGCC
  AGAATTATCTTGTGATTATTTGAGAGATGTATCAGTTTCTTCTGAAGTACAATCAACTGT
  AGAAGCCTTTGTAGCAGTTTGTTGCATATTCTAAGGACCCAGACATAGGCTTGGTGGCCC
  GTCTCTTGTCTTTCCTGGTTTATGACTTTCGGCTTTGTGGAATACGGCTGAGATGAAAGG
  ATTTATTGATGATGCAAACTACTCCGTTGGCCTGTTGGATGAAGGAACAAACCTTGGAAA
  TGTTATTGATAACTATGTTTATGAACATACCCTGACAGGGAAAAATGCATTTTTTGTGGG
  AGATCTTGGAAAGATTGTGAAGAAACACAGTCAATGGCAGAATGTAGTGGCTCAGATAAA
  GCCATTCTACACAGTGAAGTGCAACTCTGCTCCAGCTGTACTTGAGATTTTGGCAGCTCT
  TGGAACCGGATTTGCTTGTTCCAGTAAAAATGAAATGGCTTTAGTGCAAGAGTTGGGTGT
  ACCTCCAGAAAACATTATTTACATAAGTCCTTGCAAGCAAGTGTCTCAGATAAAGTATGC
  AGCAAAAGTTGGAGTGAATATCCTGACATGTGACAATGAAATTGAATTGAAGAAAATTGC
  ACGTAATCACCCAAATGCCAAGGTCTTACTACATATTGCAACAGAAGATAATATTGGAGG
  TGAAGAGGGTAACATGAAGTTTGGCACTACCCTGAAGAACTGTAGGCATCTCTTGGAATG
  TGCTAAGGAACTTGATGTCCAAATAATTGGGGTTAAATTTCATGTTTCGAGTGCTTGCAA
  AGAATCTCAAGTATATGTACATGCTCTATCTGATGCTCGATGTGTGTTTGACATGGCTGG
  AGAAATTGGCTTTACGATGAACATGTTAGACATTGGTGGAGGATTCACGGGAACTGAATT
  TCAATTGGAAGAGGTTAATCATGTTATCAGCCCTCTGTTGGATATCTACTTTCCTGAAGG
  ATCTGGTGTTAAGATAATTTCAGAACCCGGAAGCTACTATGTGTCTTCTGCATTTACACT
  CGCAGTTAATATCATAGCAAAGAAAGTTGTTGAAAATGATAAATTTCCCTCTGGAGTAGA
  AAAAACCGGAAGTGATGAACCAGCCTTCATGTATTATATGAATGATGGTGTTTATGGTTC
  TTTTGCAAGTAAACTGTCTGAGGACTTAAATACCATTCCAGAGGTTCACAAGAAATACAA
  GGAAGATGAGCCTCTGTTTACAAGCAGCCTTTGGGGTCCATCCTGTGATGAGCTTGATCA
  AATTGTGGAAAGCTGTCTTCTTCCTGAGCTGAATGTGGGAGATTGGCTTATCTTTGATAA
  CATGGGAGCAGATTCTTTCCATGAACCATCTGCTTTTAATGATTTTCAGAGGCCAGCCAT
  TTATTACATGATGTCATTCAGTGATTGGTATGAGATGCAAGATGCTGGAATTACTTCAGA
  CTCAATGATGAAGAACTTCTTCTTTGTGCCTTCTTGCATTCAGCTGAGCCAAGAAGACAG
  CTTTTCCGCTGAAGCTTAAACAGGCATTAACGCTTCTTTAGATCTGAAGTTGCAGGTTAA
  GCTTGTCTGGTCAACATTCCAGTGTGGAAAAATAATTTAAACAATCTTATTCTCTTAATT
  CTTTTGGCAACAAAAACTATTAGTAATAGCTATTTGGGACCAGACAAAATCAGCTTTCAT
  CTATAATTCATTGGGGATAATGGGAGATTTAGATAATGTATCCAGATTTAAACCTACCAG
  TTTGTCCTACCCCTTAAGCGTTTAAAATAAAATATGCAACAAAATGGATGACTTAGTGGA
  GATGGAAGCCCATTAATTGGGTTCCCCATTAAATCGTTTACATACAAGAACACAGTTTTT
  ATACTAAGGATTTGTGTTTAAAGTCTTGTAAAGTTCATGTCTTTCACCCAGATATATCAA
  ATGTTAGAAGACCAGTGTGACTTCATTAGATAACGTTTAGTGTATTTAGAATGTGTAAAT
  TTGTGCTTTGAACTGTAGTTTAATAAATGTAAAATTGCATCATAGTATTTGTTGACCTAA
  TGTAACCCTTGTATGATTGCAATAAAATTTTGTGTAGATTTTACTGTTTTTTCAGGCTAA
  AACTTTGGGAAAGGGGCTAGCTAGCAAAGGTAGTTTTGAAATAGATGTGTATATGGACTG
  TTTTGAAGGGTTTTTTTCTTTATAGCCCAGTTAAGTTTTGTTTGGCTCGGTGCATTTTTC
  ATTTATTTAATTAGTAATTTAAGTAAAGTGTTTGGTAAATCATAAAAAAAAAAAAAAAAA
  AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_015878.4 unedited
  GGGCCATTTGTATACGACTCCTATAGGGCGGCCGGGAATTCGGCACGAGGCGCAGTTTTT
  CCTTTTTTCTTCTGCCGTCGCCTTCTCTGCCTCTTCTCATCCTTTCTCGCTCTGCTGCTC
  TGCAGTGTGACGAGTCCGAATCCTCTTCCCACCCAGCCCGCGCCTTTCTTCTTTTGCCTG
  CGCTGTTCTATTTCTCCTTCGGCCGCCGCCGCCACTGCTGCACACAGCTGGTGTCGGTGC
  CGCGCTTTTACCCCCAAGTCGTTCCCGCAGCCTATGGCCCAGGCCGCCTTGGGTATTTCT
  GCTCAAGGTAACCACATCCCTCTTTAAAAATTCCGCCGAAAAAGAGAAGACGCTTTACCC
  GACTCTTTGGGCCGTTATCTCACGGCGAACTTTCTGACCAAGTATACAACTACCCAGAGG
  GCCTAGGAGAAGTGCTGTATAGAGAGCAGTTCGACTTCAACGCTGAGCCACCTTGGGAAC
  CTAGCTGATGATAGGGGGGTTCCATCTCCCAACTTGTCCATGGAGGTCTTCACTTCAGAA
  ATCCAAGACTCATATTCATCCAGCTTGGTGTCAAGTGGGCTGTTGCTGCCAGAATTATCT
  TGTGATTATTTGAGAGATGTATCAGTTTCTTCTGAAGTACAATCAACTGTAGAAGCCTTT
  GTAGCAGTTTGTTGCATATTCTAAGGACCCAGACATAGGCTTGGTGGCCCGTCTCTTGTC
  TTTCCTGGTTTATGACTTTCGGCTTTGTGGAATACGGCTGAGATGAAAGGATTTATTGAT
  GATGCAAACTACTCCGTTGGCCTGTTGGATGAAGGAACAAACCTTGCAATGTTATTGATA
  ACTATGTTTTATGACATACCTGAACAGGGAAATGCATTTTTTGGTGGGGAGAATCTTGAA
  GATTGTGAGAACAACAGTCATGCAGAATGTTAGTGGCCTCAAATAAAAGCCATTTCTACA
  CCAGGTGAAGTTGGCACTC
• Restriction Sites: Please inquire
• ACCN: NM_015878
• ORF Size: 1347 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_015878.4, NP_056962.2
• RefSeq Size: 4348
• RefSeq ORF: 1347
• Locus ID: 51582
• Domains: Orn_Arg_deC_N
• Protein Families: Druggable Genome
• Gene Summary: The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014]
  Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform.