gamma Catenin (JUP) (NM_002230) Human Untagged Clone

CAT#: SC324466

JUP (untagged)-Human junction plakoglobin (JUP), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: JUP
• Synonyms: CTNNG; DP3; DPIII; PDGB; PKGB
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_002230.1 GGCAGAAGCGCATGAGGCTGTGGGACTTGCCTTCCATTTGATTTCTGAATTGTGAAGGTG
  CATGCTTTCTGGAGGCCTGCACAGACCTTTCCCACCCGCTTTCCTGAAAGAATTTGACAG
  GGAAAGTGAGACCGCAGGAAGGCTTTTTGGGGGAAGGTTTCTTCAATGCTAGACTCTCTC
  AGGCAGAGCTGCATCGGGCCCCCTGCCTTCCCTGCTCCCAATTTCCTGAGACCGCCCGCC
  CCCACCCAGAATTGGGGATCTTGATCAGGTAGCCACGATGGAGGTGATGAACCTGATGGA
  GCAGCCTATCAAGGTGACTGAGTGGCAGCAGACATACACCTACGACTCGGGTATCCACTC
  GGGCGCCAACACCTGCGTGCCCTCCGTCAGCAGCAAGGGCATCATGGAGGAGGATGAGGC
  CTGCGGGCGCCAGTACACGCTCAAGAAAACCACCACTTACACCCAGGGGGTGCCCCCCAG
  CCAAGGTGACCTGGAGTACCAGATGTCCACAACAGCCAGGGCCAAACGGGTGCGGGAGGC
  CATGTGCCCTGGTGTGTCAGGCGAGGACAGCTCGCTTCTGCTGGCCACCCAGGTGGAGGG
  GCAGGCCACCAACCTGCAGCGACTGGCCGAGCCGTCCCAGCTGCTCAAGTCGGCCATTGT
  GCATCTCATCAACTACCAGGATGATGCCGAGCTGGCCACTCGCGCCCTGCCCGAGCTCAC
  CAAACTGCTCAACGACGAGGACCCGGTGGTGGTGACCAAGGCGGCCATGATTGTGAACCA
  GCTGTCGAAGAAGGAGGCGTCGCGGCGGGCCCTGATGGGCTCGCCCCAGCTGGTGGCCGC
  TGTCGTGCGTACCATGCAGAATACCAGCGACCTGGACACAGCCCGCTGCACCACCAGCAT
  CCTGCACAACCTCTCCCACCACCGGGAGGGGCTGCTCGCCATCTTCAAGTCGGGTGGCAT
  CCCTGCTCTGGTCCGCATGCTCAGCTCCCCTGTGGAGTCGGTCCTGTTCTATGCCATCAC
  CACGCTGCACAACCTGCTCCTGTACCAGGAGGGCGCCAAGATGGCCGTGCGCCTGGCCGA
  CGGGCTGCAAAAGATGGTGCCCCTGCTCAACAAGAACAACCCCAAGTTCCTGGCCATCAC
  CACCGACTGCCTGCAGCTCCTGGCCTACGGCAACCAGGAGAGCAAGCTGATCATCCTGGC
  CAATGGTGGGCCCCAGGCCCTCGTGCAGATCATGCGTAACTACAGTTATGAAAAGCTGCT
  CTGGACCACCAGTCGTGTGCTCAAGGTGCTATCCGTGTGTCCCAGCAATAAGCCTGCCAT
  TGTGGAGGCTGGTGGGATGCAGGCCCTGGGCAAGCACCTGACCAGCAACAGCCCCCGCCT
  GGTGCAGAACTGCCTGTGGACCCTGCGCAACCTCTCAGATGTGGCCACCAAGCAGGAGGG
  CCTGGAGAGTGTGCTGAAGATTCTGGTGAATCAGCTGAGTGTGGATGACGTCAACGTCCT
  CACCTGTGCCACGGGCACACTCTCCAACCTGACATGCAACAACAGCAAGAACAAGACGCT
  GGTGACACAGAACAGCGGTGTGGAGGCTCTCATCCATGCCATCCTGCGTGCTGGTGACAA
  GGACGACATCACGGAGCCTGCCGTCTGCGCTCTGCGCCACCTCACTAGCCGCCACCCTGA
  GGCCGAGATGGCCCAGAACTCTGTGCGTCTCAACTATGGCATCCCAGCCATCGTGAAGCT
  GCTCAACCAGCCCAACCAGTGGCCACTGGTCAAGGCAACCATCGGCTTGATCAGGAATCT
  GGCCCTGTGCCCAGCCAACCATGCCCCGCTGCAGGAGGCAGCGGTCATCCCCCGCCTCGT
  CCAACTGCTGGTGAAGGCCCACCAGGATGCCCAGCGCCACGTAGCTGCAGGCACACAGCA
  GCCCTACACGGATGGTGTGAGGATGGAGGAGATTGTGGAGGGCTGCACCGGAGCACTGCA
  CATCCTCGCCCGGGACCCCATGAACCGCATGGAGATCTTCCGGCTCAACACCATTCCCCT
  GTTTGTGCAGCTCCTGTACTCGTCGGTGGAGAACATCCAGCGCGTGGCTGCCGGGGTGCT
  GTGTGAGCTGGCCCAGGACAAGGAGGCGGCCGACGCCATTGATGCAGAGGGGGCCTCGGC
  CCCACTCATGGAGTTGCTGCACTCCCGCAACGAGGGCACTGCCACCTACGCTGCTGCCGT
  CCTGTTCCGCATCTCCGAGGACAAGAACCCAGACTACCGGAAGCGCGTGTCCGTGGAGCT
  CACCAACTCCCTCTTCAAGCATGACCCGGCTGCCTGGGAGGCTGCCCAGAGCATGATTCC
  CATCAATGAGCCCTATGGAGATGACTTGGATGCCACCTACCGCCCCATGTACTCCAGCGA
  TGTGCCCCTTGACCCGCTGGAGATGCACATGGACATGGATGGAGACTACCCCATCGACAC
  CTACAGCGACGGCCTCAGGCCCCCGTACCCCACTGCAGACCACATGCTGGCCTAGGCGGC
  CTGGCCCCAGTGCGGTTCCTCATCTGAGAGGCTCTCCGTGCAGGCGATGGGGCAAGACAG
  AAAAGTGCCTGAGCTGGGGAAGCCGGGGTGTAACTTCCTGCTGCACCCTGCGCCTCCAGA
  GGTCCTCCGTAGGGTCTTTCTTGGGATAGTGTTCTGCTCCTGCTTTTCTGTCCTGGGCAT
  GGGTCCAGGGCCTGACACCCCCTCCAGGGCCCAGGTTCGAGACCCAAACCCCCAAAATCC
  AAAACTTCTCTTGAAAAGTTCAGGGACCGTCCAGGGGAGATGGGGAGGAGATATGGAGTG
  AGTCACCTGCTCCAGAAGATGCCAGCTTCTCTCTCCAGGGTGCTTAGTTGGCTTTGCCCA
  CCCCTCACTCCCCAGGGAGCTCTGGGGACAGCTTCCTCACACCCCTGTCCCACCCACACA
  GCTGCCCTAGCTGACCCCGAGAAGTGCTCTTGGCTGACCCCTCTGGTGTGTGGTGAGGGG
  CTTTCTCTTCCCCTTCCTGTTTCAGACCCCCCCATTTCCCGCACATGGTGTGGGGGGCTG
  GGGGAGGTCCAAGCAGAGTGTTTTATTATTATCGCTTTATGTTTTTGGTTATTGGTTTTT
  TTGTATAGACCAAAGCAAAGAAAATAAAAATAACAAAAAAAAAAAAAAAAAAAAAAAA
• Restriction Sites: Please inquire
• ACCN: NM_002230
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_002230.1, NP_002221.1
• RefSeq Size: 3490 bp
• RefSeq ORF: 2238 bp
• Locus ID: 3728
• Cytogenetics: 17q21.2
• Domains: Armadillo_seg
• Protein Families: Druggable Genome
• Protein Pathways: Acute myeloid leukemia, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Pathways in cancer
• Gene Summary: 'This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008]'
  Transcript Variant: This variant (1) lacks an alternate segment in the 5' UTR, compared to transcript variant 3. Variants 1-7 encode the same protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.