Myotilin (MYOT) (NM_001135940) Human Untagged Clone

CAT#: SC324931

MYOT (untagged)-Human myotilin (MYOT), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: MYOT
• Synonyms: LGMD1; LGMD1A; MFM3; TTID; TTOD
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001135940, the custom clone sequence may differ by one or more nucleotides
  ATGGCTCGCAGATTGCTAGGACCACAGAATGCAGCTGCTGTGTTTCAAGCTCAGGATGAC
  AGTGGTGCACAAGACTCGCAGCAACACAACTCAGAACATGCGCGACTGCAAGTTCCTACA
  TCACAAGTAAGAAGTAGATCAACCTCAAGGGGAGATGTGAATGATCAGGATGCAATCCAG
  GAGAAATTTTACCCACCACGTTTCATTCAAGTGCCAGAGAACATGTCGATTGATGAAGGA
  AGATTCTGCAGAATGGACTTCAAAGTGAGTGGACTGCCAGCTCCTGATGTGTCATGGTAT
  CTAAATGGAAGAACAGTTCAATCAGATGATTTGCACAAAATGATAGTGTCTGAGAAGGGT
  CTTCATTCACTCATCTTTGAAGTAGTCAGAGCTTCAGATGCAGGGGCTTATGCATGTGTT
  GCCAAGAATAGAGCAGGAGAAGCCACCTTCACTGTGCAGCTGGATGTCCTTGCAAAAGAA
  CATAAAAGAGCACCAATGTTTATCTACAAACCACAGAGCAAAAAAGTTTTAGAGGGAGAT
  TCAGTGAAACTAGAATGCCAGATCTCGGCTATACCTCCACCAAAGCTTTTCTGGAAAAGA
  AATAATGAAATGGTACAATTCAACACTGACCGAATAAGCTTATATCAAGATAACACTGGA
  AGAGTTACTTTACTGATAAAAGATGTAAACAAGAAAGATGCTGGGTGGTATACTGTGTCA
  GCAGTTAATGAAGCTGGAGTGACTACATGTAACACAAGATTAGACGTTACGGCACGTCCA
  AACCAAACTCTTCCAGCTCCTAAGCAGTTACGGGTTCGACCAACATTCAGCAAATATTTA
  GCACTTAATGGGAAAGGTTTGAATGTAAAACAAGCTTTTAACCCAGAAGGAGAATTTCAG
  CGTTTGGCAGCTCAATCTGGACTCTATGAAAGTGAAGAACTT
  
• Restriction Sites: Please inquire
• ACCN: NM_001135940
• ORF Size: 945 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001135940.1, NP_001129412.1
• RefSeq Size: 1808
• RefSeq ORF: 945
• Locus ID: 9499
• Gene Summary: This gene encodes a cystoskeletal protein which plays a significant role in the stability of thin filaments during muscle contraction. This protein binds F-actin, crosslinks actin filaments, and prevents latrunculin A-induced filament disassembly. Mutations in this gene have been associated with limb-girdle muscular dystrophy and myofibrillar myopathies. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Oct 2008]
  Transcript Variant: This variant (2) has an alternate splice site in the 5' region, which results in translation initiation at a downstream start codon, compared to variant 1. The resulting isoform (b) has a shorter N-terminus, compared to isoform a.