PTPH1 (PTPN3) (NM_001145372) Human Untagged Clone

CAT#: SC325211

PTPN3 (untagged)-Human protein tyrosine phosphatase, non-receptor type 3 (PTPN3), transcript variant 6

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PTPN3
• Synonyms: PTP-H1; PTPH1
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001145372, the custom clone sequence may differ by one or more nucleotides
  ATGCTGAATTACCGATCTTGCAAAAACTTGTGGAAATCCTGTGTTGAGCACCATACGTTC
  TTTCAGGCAAAGAAGCTACTACCTCAGGAAAAGAATGTTCTGTCTCAGTACTGGACTATG
  GGCTCTCGGAACACCAAAAAGCGAAGTCCTCGGCTCCGGCACGAAATCCGAAAGCCACGC
  CACTCTTCTGCAGATAACCTTGCAAATGAAATGACCTACATCACGGAAACGGAAGATGTA
  TTTTACACGTACAAGGGCTCTCTGGCCCCTCAAGACAGCGATTCTGAAGTTTCTCAGAAC
  CGAAGCCCGCACCAAGAGAGTTTATCCGAGAACAATCCGGCACAAAGCTACCTGACCCAG
  AAGTCATCCAGTTCTGTGTCTCCATCTTCAAATGCTCCAGGCTCCTGCTCACCTGACGGC
  GTTGATCAGCAGCTCTTAGATGACTTCCACAGGGTGACCAAAGGGGGCTCCACCGAGGAC
  GCCAGCCAGTACTACTGTGACAAGAATGATAATGGTGACAGCTACTTAGTCTTGATCCGT
  ATCACACCAGATGAAGATGGAAAATTTGGATTTAATCTTAAGGGAGGAGTGGATCAAAAG
  ATGCCTCTTGTGGTATCAAGGATAAACCCAGAGTCACCTGCGGACACCTGCATTCCTAAG
  CTGAACGAAGGGGATCAAATCGTGTTAATCAATGGCCGGGACATCTCAGAACACACGCAT
  GACCAAGTGGTGATGTTCATCAAAGCCAGCCGGGAGTCCCACTCACGGGAGCTGGCCCTG
  GTGATCAGGAGGAGAGCTGTCCGCTCATTTGCTGACTTCAAGTCTGAAGATGAACTGAAC
  CAGCTTTTCCCCGAAGCCATTTTCCCCATGTGTCCGGAGGGTGGGGACACTTTGGAGGGA
  TCCATGGCACAGCTAAAGAAGGGCCTCGAAAGCGGGACGGTGCTGATCCAGTTTGAGCAA
  CTCTACAGAAAAAAGCCAGGTTTGGCCATCACGTTTGCAAAGCTGCCTCAAAATTTGGAC
  AAAAACCGATATAAAGATGTGCTGCCTTATGACACCACCCGGGTATTATTGCAGGGAAAT
  GAAGATTATATTAATGCAAGTTACGTGAACATGGAAATTCCTGCTGCTAACCTTGTGAAC
  AAGTACATCGCCACTCAGGGGCCCCTGCCGCATACCTGTGCACAGTTTTGGCAGGTTGTC
  TGGGATCAGAAGTTGTCACTCATTGTCATGTTGACGACTCTCACAGAACGAGGGCGGACC
  AAATGTCACCAGTACTGGCCAGATCCCCCCGACGTCATGAACCACGGCGGCTTTCACATC
  CAGTGTCAGTCAGAGGACTGCACCATCGCCTATGTGTCCCGAGAAATGCTGGTCACAAAC
  ACCCAGACCGGGGAAGAACACACAGTGACACATCTCCAGTACGTCGCATGGCCTGACCAC
  GGTGTGCCCGATGACTCCTCCGACTTTCTGGAATTTGTAAACTATGTGAGGTCTCTGAGA
  GTGGACAGCGAGCCCGTCCTAGTTCACTGCAGTGCTGGAATAGGTCGAACCGGTGTGTTG
  GTCACTATGGAAACAGCCATGTGCCTAACTGAGAGGAACCTGCCCATTTACCCACTGGAT
  ATTGTCCGAAAAATGCGAGACCAGCGCGCCATGATGGTGCAGACATCAAGCCAGTACAAG
  TTTGTGTGTGAAGCGATTCTTCGTGTGTATGAAGAAGGTTTAGTCCAAATGCTGGATCCT
  AGT
  
• Restriction Sites: Please inquire
• ACCN: NM_001145372
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001145372.1, NP_001138844.1
• RefSeq Size: 6082 bp
• RefSeq ORF: 1746 bp
• Locus ID: 5774
• Cytogenetics: 9q31.3
• Protein Families: Druggable Genome, Phosphatase
• Gene Summary: 'The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]'
  Transcript Variant: This variant (6) differs in the 5' UTR, and is missing an in-frame coding exon compared to transcript variant 1, resulting in an isoform (6) with a shorter N-terminus and lacking an internal protein segment compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.