SnoN (SKIL) (NM_001145098) Human Untagged Clone

CAT#: SC325264

SKIL (untagged)-Human SKI-like oncogene (SKIL), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SKIL
• Synonyms: SNO; SnoA; SnoI; SnoN
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001145098, the custom clone sequence may differ by one or more nucleotides
  ATGGGAGATGATGGCAGCCCCCCAGCGAAAAAAATGATAACGGACATTCATGCAAATGGA
  AAAACGATAAACAAGGTGCCAACAGTTAAGAAGGAACACTTGGATGACTATGGAGAAGCA
  CCAGTGGAAACTGATGGAGAGCATGTTAAGCGAACCTGTACTTCTGTTCCTGAAACTTTG
  CATTTAAATCCCAGTTTGAAACACACATTGGCACAATTCCATTTAAGTAGTCAGAGCTCG
  CTGGGTGGACCAGCAGCATTTTCTGCTCGGCATTCCCAAGAAAGCATGTCGCCTACTGTA
  TTTCTGCCTCTTCCATCACCTCAGGTTCTTCCTGGCCCATTGCTCATCCCTTCAGATAGC
  TCCACAGAACTCACTCAGACTGTGTTGGAAGGGGAATCTATTTCTTGTTTTCAAGTTGGA
  GGAGAAAAGAGACTCTGTTTGCCCCAAGTCTTAAATTCTGTTCTCCGAGAATTTACACTC
  CAGCAAATAAATACAGTGTGTGATGAACTGTACATATATTGTTCAAGGTGTACTTCAGAC
  CAGCTTCATATCTTAAAGGTACTGGGCATACTTCCATTCAATGCCCCATCCTGTGGGCTG
  ATTACATTAACTGATGCACAAAGATTATGTAATGCTTTATTGCGGCCACGAACTTTTCCT
  CAAAATGGTAGCGTACTTCCTGCTAAAAGCTCATTGGCCCAGTTAAAGGAAACTGGCAGT
  GCCTTTGAAGTGGAGCATGAATGCCTAGGCAAATGTCAGGGTTTATTTGCACCCCAGTTT
  TATGTTCAGCCTGATGCTCCGTGTATTCAATGTCTGGAGTGTTGTGGAATGTTTGCACCC
  CAGACGTTTGTGATGCATTCTCACAGATCACCTGACAAAAGAACTTGCCACTGGGGCTTT
  GAATCAGCTAAATGGCATTGCTATCTTCATGTGAACCAAAAATACTTAGGAACACCTGAA
  GAAAAGAAACTGAAGATAATTTTAGAAGAAATGAAGGAGAAGTTTAGCATGAGAAGTGGA
  AAGAGAAATCAATCCAAGACAGATGCACCATCAGGAATGGAATTACAGTCATGGTATCCT
  GTTATAAAGCAGGAAGGTGACCATGTTTCTCAGACACATTCATTTTTACACCCCAGCTAC
  TACTTATACATGTGTGATAAAGTGGTTGCCCCAAATGTGTCACTTACTTCTGCTGTATCC
  CAGTCTAAAGAGCTCACAAAGACAGAGGCAAGTAAGTCCATATCAAGACAGTCAGAGAAG
  GCTCACAGTAGTGGTAAACTTCAAAAAACAGTGTCTTATCCAGATGTCTCACTTGAGGAA
  CAGGAGAAAATGGATTTAAAAACAAGTAGAGAATTATGTAGCCGTTTAGATGCATCAATC
  TCAAATAATTCTACAAGTAAAAGGAAATCTGAGTCTGCCACTTGCAACTTAGTCAGAGAC
  ATAAACAAAGTGGGAATTGGCCTTGTTGCTGCCGCTTCATCTCCGCTTCTTGTGAAAGAT
  GTCATTTGTGAGGATGATAAGGGAAAAATCATGGAAGAAGTAATGAGAACTTATTTAAAA
  CAACAGGAAAAACTAAACTTGATTTTGCAAAAGAAGCAACAACTTCAGATGGAAGTAAAA
  ATGTTGAGTAGTTCAAAATCTATGAAGGAACTCACTGAAGAACAGCAGAATTTACAGAAA
  GAGCTTGAATCTTTGCAGAATGAACATGCTCAAAGAATGGAAGAATTTTATGTTGAACAG
  AAAGACTTAGAGAAAAAATTGGAGCAGATAATGAAGCAAAAATGTACCTGTGACTCAAAT
  TTAGAAAAAGACAAAGAGGCTGAATATGCAGGACAGTTGGCAGAACTGAGGCAGAGATTG
  GACCATGCTGAGGCCGATAGGCAAGAACTCCAAGATGAACTCAGACAGGAACGGGAAGCA
  AGACAGAAGTTAGAGATGATGATAAAAGAGCTAAAGCTGCAAATTCTGAAATCATCAAAG
  ACTGCTAAAGAA
  
• Restriction Sites: Please inquire
• ACCN: NM_001145098
• Insert Size: 6711 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001145098.1, NP_001138570.1
• RefSeq Size: 6711 bp
• RefSeq ORF: 6711 bp
• Locus ID: 6498
• Cytogenetics: 3q26.2
• Protein Families: Druggable Genome, Transcription Factors
• Gene Summary: 'The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]'
  Transcript Variant: This variant (3) differs in the 5' UTR and coding region, and uses a downstream start codon compared to variant 1. The resulting protein (isoform 3) is shorter compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.