DMTF1 (NM_001142326) Human Untagged Clone

CAT#: SC325272

DMTF1 (untagged)-Human cyclin D binding myb-like transcription factor 1 (DMTF1), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: DMTF1
• Synonyms: DMP1; DMTF; hDMP1; MRUL
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001142326, the custom clone sequence may differ by one or more nucleotides
  ATGACTGCAACCACAGAAGTAGCAGATGATGAGGTTACTGAGGGGACTGTGACACAGATA
  CAGATTTTGCAGAATGAGCAACTAGATGAAATATCTCCCTTGGGTAACGAGGAAGTTTCA
  GCAGTTAGCCAAGCATGGTTTACAACTAAAGAAGATAAGGATTCTCTGACTAATAAAGGA
  CATAAATGGAAGCAGGGGATGTGGTCCAAGGAAGAAATTGATATTTTGATGAACAATATT
  GAACGCTATCTTAAGGCACGCGGAATAAAAGATGCTACAGAAATCATCTTTGAGATGTCA
  AAAGACGAAAGAAAAGATTTCTACAGGACTATAGCATGGGGTCTGAACCGGCCTTTGTTT
  GCAGTTTATAGAAGAGTGCTTCGCATGTATGATGACAGAAACCATGTGGGAAAATATACA
  CCTGAAGAAATTGAGAAGCTCAAGGAGCTCCGGATAAAGCATGGCAATGACTGGGCAACA
  ATAGGGGCGGCGCTAGGAAGAAGTGCATCTTCTGTCAAAGATCGGTGCCGACTGATGAAG
  GATACTTGCAACACAGGGAAGTGGACAGAAGAAGAAGAAAAGAGACTTGCAGAAGTGGTT
  CATGAGTTGACAAGCACTGAGCCAGGTGACATAGTCACACAGGGTGTGTCTTGGGCAGCT
  GTGGCTGAACGAGTCGGTACCCGCTCAGAAAAGCAATGTCGTTCTAAATGGCTCAACTAC
  CTGAATTGGAAACAGAGTGGGGGTACTGAATGGACCAAGGAAGATGAAATCAATCTCATC
  CTCAGGATAGCAGAACTTGATGTAGCTGATGAAAATGACATTAACTGGGATCTGTTAGCT
  GAGGGATGGAGTAGTGTCCGTTCACCACAATGGCTACGAAGTAAATGGTGGACCATCAAA
  AGGCAAATTGCAAACCATAAGGATGTTTCGTTCCCTGTCTTAATAAAAGGTCTTAAACAG
  TTACATGAGAACCAAAAAAACAACCCAACGCTTTTGGAGAATAAATCAGGATCTGGAGTT
  CCAAACAGTAATACCAATTCCAGTGTGCAGCATGTTCAGATAAGAGTTGCCCGCTTGGAA
  GATAATACAGCCATCTCTTCTAGCCCCATGGCAGCATTGCAGATTCCAGTCCAGATCACC
  CATGTTTCTTCAGCAGACTCTCCTGCTACCGTTGACTCAGAAACAATAACACTAAACAGT
  GGAACACTACAGACATTTGAGATTCTTCCCTCTTTCCATCTACAGCCCACTGGCACTCCA
  GGCACCTACCTACTTCAAACAAGCTCAAGCCAAGGCCTTCCCCTAACTCTGACTGCTAGT
  CCCACAGTAACCCTGACAGCTGCTGCTCCTGCTTCTCCTGAACAGATTATTGTTCATGCT
  TTATCCCCAGAACATTTGTTGAACACAAGTGATAATGTTACAGTGCAGTGTCACACACCA
  AGAGTCATCATTCAGACTGTTGCCACAGAGGACATCACTTCTTCCATATCCCAAGCAGAA
  CTGACAGTCGATAGTGATATTCAGTCATCTGATTTTCCTGAGCCTCCAGACGCCCTAGAA
  GCAGACACTTTCCCAGATGAAATTCATCACCCTAAGATGACTGTGGAGCCATCATTTAAT
  GATGCTCATGTATCCAAATTCAGTGACCAAAATAGCACAGAACTGATGAATAGTGTTATG
  GTCAGAACAGAAGAAGAAATCTCTGACACCGACCTTAAACAAGAGGAATCACCCTCTGAT
  TTAGCCAGTGCTTATGTTACTGAGGGTTTAGAGTCTCCCACTATAGAAGAACAAGTTGAT
  CAAACAATTGATGATGAAACAATACTTATCGTTCCTTCACCACATGGCTTTATCCAGGCA
  TCTGATGTTATAGATACTGAATCTGTCTTGCCTTTGACAACACTAACAGATCCCATACTC
  CAACATCATCAGGAAGAATCAAATATCATTGGATCATCCTTGGGCAGTCCTGTTTCAGAA
  GATTCAAAGGATGTCGAAGATTTGGTAAACTGTCAT
  
• Restriction Sites: Please inquire
• ACCN: NM_001142326
• ORF Size: 2019 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001142326.1, NP_001135798.1
• RefSeq Size: 3684
• RefSeq ORF: 2019
• Locus ID: 9988
• Protein Families: Transcription Factors
• Gene Summary: This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
  Transcript Variant: This variant (3) differs in the 5' UTR and lacks a 5' coding exon, compared to variant 1. These differences cause translation initiation at a downstream AUG and an isoform (b) with a shorter N-terminus compared to isoform a.