MSL2L1 (MSL2) (NM_001145417) Human Untagged Clone

CAT#: SC326485

MSL2 (untagged)-Human male-specific lethal 2 homolog (Drosophila) (MSL2), transcript variant 2, mRNA

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: MSL2
• Synonyms: MSL-2; MSL2L1; RNF184
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001145417, the custom clone sequence may differ by one or more nucleotides
  ATGATGATGAAACCTTCCTGTAGCTGGTGCAAAGACTATGAGCAGTTTGAGGAAAACAAG
  CAGTTAAGCATCCTAGTGAACTGCTACAAAAAACTATGCGAGTATATAACACAGACTACA
  CTGGCACGGGATATAATAGAAGCAGTTGACTGTTCTTCTGATATTTTGGCTTTGCTTAAT
  GATGGATCATTGTTTTGTGAGGAGACAGAAAAACCCTCAGATTCATCCTTTACTTTGTGT
  TTGACACATTCCCCTTTACCTTCAACCTCAGAACCCACAACTGATCCTCAAGCTAGTTTA
  TCTCCAATGTCTGAAAGCACCCTCAGCATTGCTATTGGCAGTTCTGTTATCAATGGTTTG
  CCTACTTATAATGGGCTTTCAATAGATAGATTTGGTATAAATATTCCTTCACCTGAACAT
  TCAAATACGATTGACGTATGTAATACTGTTGACATAAAAACTGAGGATCTGTCTGACAGC
  CTGCCACCCGTTTGTGACACAGTAGCCACTGACTTATGTTCCACAGGCATTGATATCTGC
  AGTTTCAGTGAAGATATAAAACCTGGAGACTCTCTGTTACTGAGTGTTGAGGAAGTACTC
  CGCAGCTTAGAAACTGTTTCAAATACAGAGGTCTGTTGCCCTAATTTGCAGCCGAACTTG
  GAAGCCACTGTATCCAATGGACCTTTTCTGCAGCTTTCTTCCCAGTCTCTTAGCCATAAT
  GTTTTTATGTCCACCAGTCCTGCACTTCATGGGTTATCATGTACAGCAGCAACTCCGAAG
  ATAGCAAAATTGAATAGAAAACGATCCAGATCAGAGAGTGACAGTGAGAAAGTTCAGCCA
  CTTCCAATTTCTACCATTATCCGAGGCCCAACACTGGGGGCATCTGCTCCTGTGACAGTG
  AAACGGGAGAGCAAAATTTCTCTTCAACCTATAGCAACTGTTCCCAATGGAGGCACAACA
  CCTAAAATCAGCAAAACTGTACTTTTATCTACTAAAAGCATGAAAAAGAGTCATGAACAT
  GGATCCAAGAAATCTCACTCTAAAACCAAGCCAGGTATTCTTAAAAAAGACAAAGCAGTA
  AAGGAAAAGATTCCTAGTCATCATTTTATGCCAGGAAGTCCTACCAAGACTGTGTACAAA
  AAACCCCAGGAAAAGAAAGGGTGTAAATGTGGGCGTGCTACTCAAAATCCAAGTGTTCTT
  ACATGCCGAGGCCAACGCTGCCCTTGCTACTCTAACCGCAAAGCCTGCTTAGATTGTATA
  TGTCGTGGCTGCCAAAACTCCTATATGGCCAATGGGGAGAAGAAGCTGGAGGCATTTGCC
  GTGCCAGAAAAGGCCTTGGAGCAGACCAGGCTCACTTTGGGCATTAACGTGACTAGCATT
  GCTGTGCGTAACGCTAGTACCAGCACCAGTGTAATAAATGTCACAGGGTCCCCAGTAACG
  ACGTTTTTAGCTGCCAGTACACATGATGATAAAAGTTTGGATGAAGCTATAGACATGAGA
  TTCGACTGT
  
• Restriction Sites: Please inquire
• ACCN: NM_001145417
• ORF Size: 1512 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001145417.1, NP_001138889.1
• RefSeq Size: 3895
• RefSeq ORF: 1512
• Locus ID: 55167
• Protein Families: Druggable Genome
• Gene Summary: Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. [UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (2) uses an alternate 5' end exon, therefore, has a different 5' UTR compared to transcript variant 1. This results in translation initiation from an in-frame downstream AUG and an isoform (2) with a shorter N-terminus compared to isoform 1.